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- W1977756200 abstract "In this study the results of surgery and radiotherapy (RT) in 26 patients, compared with those of 42 patients who had only RT are analyzed. The most frequent sites of primary tumors were the lung and breast. In the first years 20 × 2 Gy was given; later on 10 × 3 Gy was administered. Sixteen non-operated patients received 20 × 2 Gy followed by a local boost of 10–20 Gy. Because a matched cohort pair method was chosen for this analysis, all prognostic factors were equally distributed between the operation (OP) + whole-brain irradiation (WBI) and the WBI only group. The local remission rate after OP + WBI was 81% vs. 38.5% after WBI only and 69% after WBI + boost. Median survival after surgery (17 months) was significantly longer, but the dose of RT had no influence on survival (7 vs. 8 months). The distribution of prognostic factors was significantly different between the WBI + boost group and the other groups, and therefore a prospective randomized trial will become necessary to verify the superiority of surgical treatment compared to “high-dose” RT. When compared to “standard” RT equivalent to the 10 × 3 Gy schedule, surgery + RT is significantly superior. © Wiley-Liss, Inc." @default.
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- W1977756200 date "1994-01-01" @default.
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- W1977756200 title "Value of surgery and radiotherapy in the treatment of brain metastases" @default.
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- W1977756200 doi "https://doi.org/10.1002/roi.2970020108" @default.
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