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- W1977756245 abstract "B-HT920 is known to be a selective α2-adrenoceptor agonist, and has been used in a study on morphine-withdrawal in rats. In accordance with other α2-agonists B-HT920 was found to potentiate “jumping” and to reduce “body shakes.” However, B-HT920 did not suppress body weight loss. Furthermore, it induced strong salivation and prevented ptosis (described for the α1-adrenergic agonist ST-587). Rearing and locomotor activity appeared to be enhanced, an effect shared by dopamine-agonist lisurid. The effects of B-HT920 have been specified using the α-adrenergic antagonists yohimbine and prazosin and the dopamine antagonist haloperidol. Yohimbine could not antagonize any of the actions of B-HT920. However the increase in rearing and locomotion was blocked by haloperidol. The induction of salivation was prevented by prazosin. Pretreatment with prazosin showed a decrease in the loss of body weight caused by B-HT920, while pretreatment with yohimbine showed that B-HT920 induced an increased loss in body weight. These data suggest that B-HT920 under certain conditions exerts dopamine-agonistic actions in stimulating locomotor activity and α1-adrenergic actions in inducing salivation and enhanced loss of body weight." @default.
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- W1977756245 date "1987-02-01" @default.
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- W1977756245 title "Dopaminertic and α1-adrenergic properties of B-HT920 revealed in morphine-dependent rats" @default.
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- W1977756245 doi "https://doi.org/10.1016/0091-3057(87)90116-x" @default.
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