FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977757200> ?p ?o ?g. }

• W1977757200 endingPage "373" @default.
• W1977757200 startingPage "363" @default.
• W1977757200 abstract "Tea contains a variety of bioactive chemicals, such as catechins and other polyphenols. These compounds are thought to be responsible for the health benefits of tea consumption by affecting the function of many cellular targets, not all of which have been identified. In a high-throughput screen for small molecule antagonists of the EphA4 receptor tyrosine kinase, we identified five tea polyphenols that substantially inhibit EphA4 binding to a synthetic peptide ligand. Further characterization of theaflavin monogallates from black tea and epigallocatechin-3,5-digallate from green tea revealed that these compounds at low micromolar concentrations also inhibit binding of the natural ephrin ligands to EphA4 and several other Eph receptors in in vitro assays. The compounds behave as competitive EphA4 antagonists, and their inhibitory activity is affected by amino acid mutations within the ephrin binding pocket of EphA4. In contrast, the major green tea catechin, epigallocatechin-3-gallate (EGCG), does not appear to be an effective Eph receptor antagonist. In cell culture assays, theaflavin monogallates and epigallocatechin-3,5-digallate inhibit ephrin-induced tyrosine phosphorylation (activation) of Eph receptors and endothelial capillary-like tube formation. However, the wider spectrum of Eph receptors affected by the tea derivatives in cells suggests additional mechanisms of inhibition besides interfering with ephrin binding. These results show that tea polyphenols derived from both black and green tea can suppress the biological activities of Eph receptors. Thus, the Eph receptor tyrosine kinase family represents an important class of targets for tea-derived phytochemicals." @default.
• W1977757200 created "2016-06-24" @default.
• W1977757200 creator A5022796313 @default.
• W1977757200 creator A5042943624 @default.
• W1977757200 creator A5045615826 @default.
• W1977757200 creator A5069934756 @default.
• W1977757200 date "2012-10-01" @default.
• W1977757200 modified "2023-10-18" @default.
• W1977757200 title "Inhibition of Eph receptor–ephrin ligand interaction by tea polyphenols" @default.
• W1977757200 cites W1538422719 @default.
• W1977757200 cites W1549328326 @default.
• W1977757200 cites W1569637190 @default.
• W1977757200 cites W1584018958 @default.
• W1977757200 cites W1608418464 @default.
• W1977757200 cites W1813767736 @default.
• W1977757200 cites W1933663256 @default.
• W1977757200 cites W1967628309 @default.
• W1977757200 cites W1970472634 @default.
• W1977757200 cites W1973143681 @default.
• W1977757200 cites W1973648086 @default.
• W1977757200 cites W1980819464 @default.
• W1977757200 cites W1983392133 @default.
• W1977757200 cites W1987237521 @default.
• W1977757200 cites W1987263161 @default.
• W1977757200 cites W1989381307 @default.
• W1977757200 cites W1992187858 @default.
• W1977757200 cites W1994137567 @default.
• W1977757200 cites W1994662389 @default.
• W1977757200 cites W1997670728 @default.
• W1977757200 cites W2005157049 @default.
• W1977757200 cites W2017693133 @default.
• W1977757200 cites W2020493358 @default.
• W1977757200 cites W2030371171 @default.
• W1977757200 cites W2030537346 @default.
• W1977757200 cites W2038647597 @default.
• W1977757200 cites W2039328745 @default.
• W1977757200 cites W2040080794 @default.
• W1977757200 cites W2041099281 @default.
• W1977757200 cites W2045824104 @default.
• W1977757200 cites W2045901576 @default.
• W1977757200 cites W2046473105 @default.
• W1977757200 cites W2047338936 @default.
• W1977757200 cites W2047970549 @default.
• W1977757200 cites W2049125990 @default.
• W1977757200 cites W2049782403 @default.
• W1977757200 cites W2050974395 @default.
• W1977757200 cites W2067266295 @default.
• W1977757200 cites W2070785261 @default.
• W1977757200 cites W2086403312 @default.
• W1977757200 cites W2087546428 @default.
• W1977757200 cites W2100772783 @default.
• W1977757200 cites W2103252347 @default.
• W1977757200 cites W2105828029 @default.
• W1977757200 cites W2107605999 @default.
• W1977757200 cites W2110110458 @default.
• W1977757200 cites W2115654943 @default.
• W1977757200 cites W2119220723 @default.
• W1977757200 cites W2120376007 @default.
• W1977757200 cites W2126044750 @default.
• W1977757200 cites W2129901781 @default.
• W1977757200 cites W2135967686 @default.
• W1977757200 cites W2145998221 @default.
• W1977757200 cites W2288845522 @default.
• W1977757200 cites W4255240474 @default.
• W1977757200 doi "https://doi.org/10.1016/j.phrs.2012.05.010" @default.
• W1977757200 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3677025" @default.
• W1977757200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22750215" @default.
• W1977757200 hasPublicationYear "2012" @default.
• W1977757200 type Work @default.
• W1977757200 sameAs 1977757200 @default.
• W1977757200 citedByCount "17" @default.
• W1977757200 countsByYear W19777572002013 @default.
• W1977757200 countsByYear W19777572002014 @default.
• W1977757200 countsByYear W19777572002017 @default.
• W1977757200 countsByYear W19777572002018 @default.
• W1977757200 countsByYear W19777572002019 @default.
• W1977757200 countsByYear W19777572002022 @default.
• W1977757200 countsByYear W19777572002023 @default.
• W1977757200 crossrefType "journal-article" @default.
• W1977757200 hasAuthorship W1977757200A5022796313 @default.
• W1977757200 hasAuthorship W1977757200A5042943624 @default.
• W1977757200 hasAuthorship W1977757200A5045615826 @default.
• W1977757200 hasAuthorship W1977757200A5069934756 @default.
• W1977757200 hasBestOaLocation W19777572002 @default.
• W1977757200 hasConcept C101544691 @default.
• W1977757200 hasConcept C170286479 @default.
• W1977757200 hasConcept C170493617 @default.
• W1977757200 hasConcept C185592680 @default.
• W1977757200 hasConcept C19331615 @default.
• W1977757200 hasConcept C2778004101 @default.
• W1977757200 hasConcept C42362537 @default.
• W1977757200 hasConcept C55493867 @default.
• W1977757200 hasConcept C70899900 @default.
• W1977757200 hasConcept C86803240 @default.
• W1977757200 hasConcept C98274493 @default.
• W1977757200 hasConceptScore W1977757200C101544691 @default.
• W1977757200 hasConceptScore W1977757200C170286479 @default.
• W1977757200 hasConceptScore W1977757200C170493617 @default.

• next