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- W1977761978 abstract "The synthesis of three classes of potential antibiotic compounds derived from 4-amino-4H-1,2,4-triazole and related to β-lactam antibiotics is described. Their originality belongs to the replacement of the β-lactam carbonyl moiety by another electrophilic centre of the same sp2 geometry. As a result, their interaction with the bacterial target enzyme might lead to the formation of a covalent complex different from the classical acylenzyme. A theoretical study of their structural analogy and their reactivity compared to those of a model β-lactam justifies their interest in the present context. However, the actual biological results indicate a lack of antibacterial activity." @default.
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- W1977761978 date "1992-04-01" @default.
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- W1977761978 title "Synthèse, étude théorique et évaluation biologique de dérivés du 4-amino-4H-1,2,4-triazole analogues des antibiotiques β-lactamiques" @default.
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