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- W1977796316 abstract "The purpose of this pilot study was to evaluate the feasibility and toxicity of concurrent chemotherapy with vinorelbine and mitomycin C in combination with accelerated radiotherapy (RT) in patients with locally advanced cancer of the head and neck.Between January 2003 and March 2004, 15 patients with T4/N2-3 squamous cell carcinoma (12/15) and with N3 cervical lymph node metastases of carcinoma of unknown primary (3/15) were treated with chemotherapy and simultaneous accelerated RT.11 patients completed therapy without interruption or dose reduction. Grade 3-4 acute mucosal toxicity was observed in 9/15 patients, grade 4 hematologic toxicity in 6/15 patients. At a median follow-up of 7.5 months, 2 patients have died of intercurrent disease, 2 patients have experienced local relapse; 5 patients are alive with no evidence of disease at the primary tumor site.The described regimen is highly effective, but led to remarkable side effects." @default.
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- W1977796316 date "2005-01-01" @default.
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- W1977796316 title "A New Concurrent Chemotherapy with Vinorelbine and Mitomycin C in Combination with Radiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck" @default.
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- W1977796316 doi "https://doi.org/10.1159/000087087" @default.
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