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- W1977800086 abstract "α1-6 Fucosyltransferase (α1-6 FucT) catalyzes the transfer of fucose to innermost GlcNAc in N-glycans. This structure on α-fetoprotein has been clinically used for early diagnosis of hepatocellular carcinoma. In this study, expression of α1-6 FucT was investigated in rat and human hepatocarcinogenesis and biological significance of α1-6 FucT on hepatoma was investigated in terms of metastasis. While α1-6 FucT was scarcely detected in normal liver, it was enhanced in LEC rat hepatoma, but not in their surrounding tissues. In contrast, high expression of α1-6 FucT mRNA was observed in human liver cirrhosis tissues as well as in hepatoma tissues. We established human hepatoma cell lines which express high levels of α1-6 FucT by transfection of α1-6 FucT gene and investigated intrahepatic metastasis after splenic injection to athymic mice. Tumor formation in the liver was dramatically suppressed in α1-6 FucT transfectants. While there were no differences of cell invasiveness and cytotoxicity to lymphocytes, cell adhesion to nonparenchymal liver cells in culture was significantly inhibited in α1-6 FucT transfectants as compared to those of controls. Attachment of α1-6 FucT transfectants to a fibronectin or laminin coated dish was decreased compared to controls. Two-dimensional electrophoresis followed by lectin blot showed certain glycoproteins were α1-6 fucosylated and might be linked to suppression of intrahepatic metastasis. Collectively, although α1-6 FucT was enhanced in rat and human hepatocarcinogenesis, overexpression of α1-6 FucT suppressed intrahepatic metastasis of hepatoma." @default.
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- W1977800086 date "1998-01-01" @default.
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- W1977800086 title "Biological significance of .ALPHA.1-6 Fucosyltransferase in hepatoma and hepatocarcinogenesis." @default.
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- W1977800086 doi "https://doi.org/10.2198/sbk.42.225" @default.
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