Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977803285> ?p ?o ?g. }
- W1977803285 endingPage "78" @default.
- W1977803285 startingPage "67" @default.
- W1977803285 abstract "Rearing young rodents in socially isolated or environmentally enriched conditions has been shown to affect numerous components of the dopamine system as well as behavior. Methylphenidate (MPH), a commonly used dopaminergic agent, may affect animals differently based on rearing environment. Here we examined the interaction between environment and chronic MPH treatment at clinically relevant doses, administered via osmotic minipump. Young Sprague Dawley rats (PND 21) were assigned to environmentally enriched, pair-housed, or socially isolated rearing conditions, and treated with either 0, 2, 4, or 8 mg/kg/day MPH for 3 weeks. At the end of the treatment period, animals were tested for locomotor activity and anxiety-like behavior. The densities of D1-like and D2-like receptors were measured in the striatum using in vitro receptor autoradiography. Locomotor activity and anxiety-like behavior were increased in isolated animals compared to pair-housed and enriched animals. The density of D1-like receptors was greater in isolated animals, but there were no differences between groups in D2-like receptor density. Finally, there were no effects of MPH administration on any reported measure. This study provides evidence for an effect of early rearing environment on the dopamine system and behavior, and also suggests that MPH administration may not have long-term consequences." @default.
- W1977803285 created "2016-06-24" @default.
- W1977803285 creator A5000901358 @default.
- W1977803285 creator A5066950134 @default.
- W1977803285 creator A5074205379 @default.
- W1977803285 creator A5085595769 @default.
- W1977803285 date "2013-08-01" @default.
- W1977803285 modified "2023-10-15" @default.
- W1977803285 title "The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats" @default.
- W1977803285 cites W1500021740 @default.
- W1977803285 cites W1635165574 @default.
- W1977803285 cites W1929442449 @default.
- W1977803285 cites W1965723380 @default.
- W1977803285 cites W1967249950 @default.
- W1977803285 cites W1968752176 @default.
- W1977803285 cites W1969359175 @default.
- W1977803285 cites W1973038290 @default.
- W1977803285 cites W1976358114 @default.
- W1977803285 cites W1977634040 @default.
- W1977803285 cites W1977732783 @default.
- W1977803285 cites W1978833848 @default.
- W1977803285 cites W1980923784 @default.
- W1977803285 cites W1983332126 @default.
- W1977803285 cites W1984869489 @default.
- W1977803285 cites W1986195948 @default.
- W1977803285 cites W1988389350 @default.
- W1977803285 cites W1988547006 @default.
- W1977803285 cites W1990060094 @default.
- W1977803285 cites W1995370658 @default.
- W1977803285 cites W1995793779 @default.
- W1977803285 cites W1996987711 @default.
- W1977803285 cites W1997944061 @default.
- W1977803285 cites W2000147989 @default.
- W1977803285 cites W2005271779 @default.
- W1977803285 cites W2005509461 @default.
- W1977803285 cites W2006015458 @default.
- W1977803285 cites W2007357434 @default.
- W1977803285 cites W2008275505 @default.
- W1977803285 cites W2010159214 @default.
- W1977803285 cites W2010999766 @default.
- W1977803285 cites W2011083427 @default.
- W1977803285 cites W2011256883 @default.
- W1977803285 cites W2012806030 @default.
- W1977803285 cites W2015530563 @default.
- W1977803285 cites W2021782736 @default.
- W1977803285 cites W2025227125 @default.
- W1977803285 cites W2025385931 @default.
- W1977803285 cites W2026985379 @default.
- W1977803285 cites W2028109978 @default.
- W1977803285 cites W2028495268 @default.
- W1977803285 cites W2028756458 @default.
- W1977803285 cites W2029604167 @default.
- W1977803285 cites W2030939829 @default.
- W1977803285 cites W2032254540 @default.
- W1977803285 cites W2032630122 @default.
- W1977803285 cites W2033304004 @default.
- W1977803285 cites W2033903440 @default.
- W1977803285 cites W2034864387 @default.
- W1977803285 cites W2034973519 @default.
- W1977803285 cites W2035247507 @default.
- W1977803285 cites W2035934447 @default.
- W1977803285 cites W2036322787 @default.
- W1977803285 cites W2036788496 @default.
- W1977803285 cites W2036803837 @default.
- W1977803285 cites W2037084677 @default.
- W1977803285 cites W2037288616 @default.
- W1977803285 cites W2037600177 @default.
- W1977803285 cites W2040151970 @default.
- W1977803285 cites W2046453280 @default.
- W1977803285 cites W2046804265 @default.
- W1977803285 cites W2050017866 @default.
- W1977803285 cites W2051028855 @default.
- W1977803285 cites W2051315778 @default.
- W1977803285 cites W2055534908 @default.
- W1977803285 cites W2055902400 @default.
- W1977803285 cites W2055984987 @default.
- W1977803285 cites W2056902640 @default.
- W1977803285 cites W2058103878 @default.
- W1977803285 cites W2059428006 @default.
- W1977803285 cites W2062289216 @default.
- W1977803285 cites W2063306678 @default.
- W1977803285 cites W2066230430 @default.
- W1977803285 cites W2068549908 @default.
- W1977803285 cites W2070494819 @default.
- W1977803285 cites W2070666079 @default.
- W1977803285 cites W2076342500 @default.
- W1977803285 cites W2077227508 @default.
- W1977803285 cites W2077624548 @default.
- W1977803285 cites W2077877676 @default.
- W1977803285 cites W2078573394 @default.
- W1977803285 cites W2084649441 @default.
- W1977803285 cites W2084679231 @default.
- W1977803285 cites W2085003408 @default.
- W1977803285 cites W2085554546 @default.
- W1977803285 cites W2086573866 @default.
- W1977803285 cites W2087628445 @default.
- W1977803285 cites W2089209229 @default.
- W1977803285 cites W2089977938 @default.