FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977824445> ?p ?o ?g. }

• W1977824445 endingPage "1175" @default.
• W1977824445 startingPage "1168" @default.
• W1977824445 abstract "Ristocetin will induce the agglutination of platelets in the presence of von Willebrand factor. In previous studies, an electrostatic mechanism was proposed for this phenomenon wherein first the platelet's surface charge is reduced by the binding of ristocetin and then the von Willebrand factor acts as a bridge between platelets. To test this hypothesis, the effects of ristocetin and von Willebrand factor, singly and together, on the electrophoretic mobility of normal, trypsinized, and Bernard-Soulier platelets was measured. Ristocetin alone, at concentrations of 0.5 mg/ml or more, produced a statistically significant reduction in the electrophoretic mobility of fresh or fixed platelets. Control experiments showed that the reduction was not due to changes in the ionic milieu of the solution. Therefore, the decrease in platelet mobility is evidence for binding of ristocetin to the platelet surface. Bernard-Soulier and trypsinized platelets also had reductions in mobility with ristocetin, suggesting that ristocetin binds to the platelet at sites other than the binding site for von Willebrand factor. The presence of plasma from a patient with von Willebrand's disease did not alter the reduction in mobility of normal platelets by ristocetin. However, the reduction was markedly enhanced in the presence of normal plasma. This enhancement did not occur with Bernard-Soulier platelets and was inhibited by anti-Factor VIII/von Willebrand factor antiserum or trypsinization of the platelets. Thus, the enhanced reduction appears to be associated with the binding of von Willebrand factor to the platelet surface. These studies indicate that platelets undergo two changes with ristocetin and von Willebrand factor, both of which facilitate agglutination: reduction in net surface charge and binding of von Willebrand factor, a large molecule which can serve as a bridge between platelets. In parallel studies, bovine von Willebrand factor, without ristocetin, agglutinated and reduced the electrophoretic mobility of normal but not Bernard-Soulier or trypsinized platelets; this indicates a similar mechanism of agglutination." @default.
• W1977824445 created "2016-06-24" @default.
• W1977824445 creator A5039564788 @default.
• W1977824445 date "1978-05-01" @default.
• W1977824445 modified "2023-09-26" @default.
• W1977824445 title "The Effects of Ristocetin and von Willebrand Factor on Platelet Electrophoretic Mobility" @default.
• W1977824445 cites W152851056 @default.
• W1977824445 cites W160258599 @default.
• W1977824445 cites W1890542340 @default.
• W1977824445 cites W1964384450 @default.
• W1977824445 cites W1980735719 @default.
• W1977824445 cites W1990790360 @default.
• W1977824445 cites W1993288590 @default.
• W1977824445 cites W1998742798 @default.
• W1977824445 cites W2003057187 @default.
• W1977824445 cites W2016299534 @default.
• W1977824445 cites W2026520335 @default.
• W1977824445 cites W2029038499 @default.
• W1977824445 cites W2047381204 @default.
• W1977824445 cites W2056451162 @default.
• W1977824445 cites W2069753926 @default.
• W1977824445 cites W2072512150 @default.
• W1977824445 cites W2080226094 @default.
• W1977824445 cites W2080322164 @default.
• W1977824445 cites W2084995423 @default.
• W1977824445 cites W2086917915 @default.
• W1977824445 cites W2106752817 @default.
• W1977824445 cites W2262283830 @default.
• W1977824445 cites W2345473432 @default.
• W1977824445 cites W2401019411 @default.
• W1977824445 cites W2405879472 @default.
• W1977824445 cites W2409683675 @default.
• W1977824445 cites W2413999496 @default.
• W1977824445 cites W2414689675 @default.
• W1977824445 cites W2433133782 @default.
• W1977824445 cites W258246773 @default.
• W1977824445 cites W2980015831 @default.
• W1977824445 doi "https://doi.org/10.1172/jci109032" @default.
• W1977824445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/372637" @default.
• W1977824445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/307006" @default.
• W1977824445 hasPublicationYear "1978" @default.
• W1977824445 type Work @default.
• W1977824445 sameAs 1977824445 @default.
• W1977824445 citedByCount "73" @default.
• W1977824445 countsByYear W19778244452012 @default.
• W1977824445 countsByYear W19778244452014 @default.
• W1977824445 countsByYear W19778244452015 @default.
• W1977824445 countsByYear W19778244452016 @default.
• W1977824445 countsByYear W19778244452018 @default.
• W1977824445 countsByYear W19778244452021 @default.
• W1977824445 countsByYear W19778244452023 @default.
• W1977824445 crossrefType "journal-article" @default.
• W1977824445 hasAuthorship W1977824445A5039564788 @default.
• W1977824445 hasBestOaLocation W19778244451 @default.
• W1977824445 hasConcept C126322002 @default.
• W1977824445 hasConcept C134018914 @default.
• W1977824445 hasConcept C181199279 @default.
• W1977824445 hasConcept C185592680 @default.
• W1977824445 hasConcept C2776057759 @default.
• W1977824445 hasConcept C2779394231 @default.
• W1977824445 hasConcept C2780340462 @default.
• W1977824445 hasConcept C38240268 @default.
• W1977824445 hasConcept C55493867 @default.
• W1977824445 hasConcept C71924100 @default.
• W1977824445 hasConcept C86803240 @default.
• W1977824445 hasConcept C89560881 @default.
• W1977824445 hasConceptScore W1977824445C126322002 @default.
• W1977824445 hasConceptScore W1977824445C134018914 @default.
• W1977824445 hasConceptScore W1977824445C181199279 @default.
• W1977824445 hasConceptScore W1977824445C185592680 @default.
• W1977824445 hasConceptScore W1977824445C2776057759 @default.
• W1977824445 hasConceptScore W1977824445C2779394231 @default.
• W1977824445 hasConceptScore W1977824445C2780340462 @default.
• W1977824445 hasConceptScore W1977824445C38240268 @default.
• W1977824445 hasConceptScore W1977824445C55493867 @default.
• W1977824445 hasConceptScore W1977824445C71924100 @default.
• W1977824445 hasConceptScore W1977824445C86803240 @default.
• W1977824445 hasConceptScore W1977824445C89560881 @default.
• W1977824445 hasIssue "5" @default.
• W1977824445 hasLocation W19778244451 @default.
• W1977824445 hasLocation W19778244452 @default.
• W1977824445 hasLocation W19778244453 @default.
• W1977824445 hasLocation W19778244454 @default.
• W1977824445 hasOpenAccess W1977824445 @default.
• W1977824445 hasPrimaryLocation W19778244451 @default.
• W1977824445 hasRelatedWork W196121877 @default.
• W1977824445 hasRelatedWork W1977824445 @default.
• W1977824445 hasRelatedWork W2021638217 @default.
• W1977824445 hasRelatedWork W2087171997 @default.
• W1977824445 hasRelatedWork W2187613753 @default.
• W1977824445 hasRelatedWork W2308864913 @default.
• W1977824445 hasRelatedWork W2402562198 @default.
• W1977824445 hasRelatedWork W2439083888 @default.
• W1977824445 hasRelatedWork W4235257442 @default.
• W1977824445 hasRelatedWork W4249416051 @default.
• W1977824445 hasVolume "61" @default.
• W1977824445 isParatext "false" @default.
• W1977824445 isRetracted "false" @default.

• next