Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977825231> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1977825231 endingPage "228" @default.
- W1977825231 startingPage "223" @default.
- W1977825231 abstract "There are changes in blood flow during the clinical stages of diabetic retinopathy with increasing leukostasis and secondary elaboration of cytokines. This study evaluated the vitreous concentrations of haemodynamic-related (endothelin-1 (ET-1) and nitric oxide (NO)), inflammatory and anti-inflammatory (interleukin-1 receptor antagonist, IL-1 Ra) cytokines in the diabetic patients (with nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR)), compared them with those of control patients (full thickness macular hole, FTMH) and correlated to macular structural indices.Vitreous samples from five FTMH patients representing normal controls were analysed together with the vitreous samples of 15 patients with NPDR and five with PDR. The vitreous concentrations of nitrite (total NO), ET-1, and prostacyclin was determined using ELISA kits (R&D Systems, Minneapolis, MN, USA) according to the manufacturer's instructions. A sandwich luminescent immunoassay technique was used to determine IL-1beta and IL-1 Ra concentrations.In the different clinical groups, there were no differences in the vitreous NO and prostacyclin concentrations. In NPDR, the median ET-1 concentration (0.7 pg/ml SD +/-0.8 pg/ml) was significantly reduced (P<0.05), compared to PDR (6.35 pg/ml SD +/-0.6 pg/ml) and FTMH (3.6 pg/ml SD +/-0.14 pg/ml). Its concentration also positively correlated with foveal thickness and macular volume (P<0.05) in patients with NPDR and macular oedema. IL-1 beta was detected in PDR, and diabetic patients demonstrated a lower concentration of the anti-inflammatory cytokine IL-1 Ra.Reduced concentrations of ET-1 in NPDR may reflect the haemodynamic changes of NPDR. The IL-1 Ra concentration suggests a change in the anti-inflammatory environment of the diabetic retina." @default.
- W1977825231 created "2016-06-24" @default.
- W1977825231 creator A5008962318 @default.
- W1977825231 creator A5044583384 @default.
- W1977825231 creator A5055076524 @default.
- W1977825231 creator A5071058522 @default.
- W1977825231 creator A5084216670 @default.
- W1977825231 date "2006-09-22" @default.
- W1977825231 modified "2023-10-13" @default.
- W1977825231 title "Concentration of haemodynamic and inflammatory related cytokines in diabetic retinopathy" @default.
- W1977825231 cites W1966938010 @default.
- W1977825231 cites W1972406484 @default.
- W1977825231 cites W2002107529 @default.
- W1977825231 cites W2011500110 @default.
- W1977825231 cites W2021277702 @default.
- W1977825231 cites W2043500156 @default.
- W1977825231 cites W2053503839 @default.
- W1977825231 cites W2094233549 @default.
- W1977825231 cites W2102665979 @default.
- W1977825231 cites W2128728937 @default.
- W1977825231 cites W2162230859 @default.
- W1977825231 cites W2171480988 @default.
- W1977825231 cites W2399250667 @default.
- W1977825231 doi "https://doi.org/10.1038/sj.eye.6702584" @default.
- W1977825231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17001327" @default.
- W1977825231 hasPublicationYear "2006" @default.
- W1977825231 type Work @default.
- W1977825231 sameAs 1977825231 @default.
- W1977825231 citedByCount "58" @default.
- W1977825231 countsByYear W19778252312012 @default.
- W1977825231 countsByYear W19778252312014 @default.
- W1977825231 countsByYear W19778252312015 @default.
- W1977825231 countsByYear W19778252312016 @default.
- W1977825231 countsByYear W19778252312017 @default.
- W1977825231 countsByYear W19778252312018 @default.
- W1977825231 countsByYear W19778252312019 @default.
- W1977825231 countsByYear W19778252312020 @default.
- W1977825231 countsByYear W19778252312021 @default.
- W1977825231 countsByYear W19778252312022 @default.
- W1977825231 crossrefType "journal-article" @default.
- W1977825231 hasAuthorship W1977825231A5008962318 @default.
- W1977825231 hasAuthorship W1977825231A5044583384 @default.
- W1977825231 hasAuthorship W1977825231A5055076524 @default.
- W1977825231 hasAuthorship W1977825231A5071058522 @default.
- W1977825231 hasAuthorship W1977825231A5084216670 @default.
- W1977825231 hasBestOaLocation W19778252311 @default.
- W1977825231 hasConcept C118487528 @default.
- W1977825231 hasConcept C126322002 @default.
- W1977825231 hasConcept C134018914 @default.
- W1977825231 hasConcept C2779829184 @default.
- W1977825231 hasConcept C2781128415 @default.
- W1977825231 hasConcept C555293320 @default.
- W1977825231 hasConcept C71924100 @default.
- W1977825231 hasConceptScore W1977825231C118487528 @default.
- W1977825231 hasConceptScore W1977825231C126322002 @default.
- W1977825231 hasConceptScore W1977825231C134018914 @default.
- W1977825231 hasConceptScore W1977825231C2779829184 @default.
- W1977825231 hasConceptScore W1977825231C2781128415 @default.
- W1977825231 hasConceptScore W1977825231C555293320 @default.
- W1977825231 hasConceptScore W1977825231C71924100 @default.
- W1977825231 hasIssue "2" @default.
- W1977825231 hasLocation W19778252311 @default.
- W1977825231 hasLocation W19778252312 @default.
- W1977825231 hasOpenAccess W1977825231 @default.
- W1977825231 hasPrimaryLocation W19778252311 @default.
- W1977825231 hasRelatedWork W106847932 @default.
- W1977825231 hasRelatedWork W188621354 @default.
- W1977825231 hasRelatedWork W1995293799 @default.
- W1977825231 hasRelatedWork W2009853508 @default.
- W1977825231 hasRelatedWork W2039530249 @default.
- W1977825231 hasRelatedWork W2046921348 @default.
- W1977825231 hasRelatedWork W228345264 @default.
- W1977825231 hasRelatedWork W2352634490 @default.
- W1977825231 hasRelatedWork W2748952813 @default.
- W1977825231 hasRelatedWork W581368896 @default.
- W1977825231 hasVolume "22" @default.
- W1977825231 isParatext "false" @default.
- W1977825231 isRetracted "false" @default.
- W1977825231 magId "1977825231" @default.
- W1977825231 workType "article" @default.