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- W1977855433 abstract "The induction of null mutations by means of homologous recombination is a powerful technique for clarifying the biological activities of target genes. However, the problems of the genetic background and flanking genes should be borne in mind. Here we employed a breeding strategy to compare three lines of mice deficient in the basigin (Bsg)/CD147 gene. The first line was F2 from F1 hybrid offspring of the 129/SV chimera and C57BL/6J. The second one was from a C57BL/6J congenic line. Both lines showed high embryonic lethality, sterility, and blindness. The third one was ‘reverse F2’ from ‘reverse F1’ hybrid offspring of the C57BL/6J congenic line and 129/SV. Surprisingly, this line showed a normal birth rate, while sterility and blindness persisted. Our results clearly separate the effects of the induced null mutation from those of flanking genes and the genetic background, and provide a useful means of investigating the biological functions of Bsg." @default.
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- W1977855433 date "2004-11-01" @default.
- W1977855433 modified "2023-09-27" @default.
- W1977855433 title "Effects of flanking genes on the phenotypes of mice deficient in basigin/CD147" @default.
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- W1977855433 doi "https://doi.org/10.1016/j.bbrc.2004.08.232" @default.
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