Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977862008> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1977862008 endingPage "919" @default.
- W1977862008 startingPage "916" @default.
- W1977862008 abstract "Summary: Patients with chronic granulomatous disease (CGD) have recurrent infections with catalase-producing organisms, particularly staphylococci, that survive within their leukocytes. To be most effective, antibiotics used to treat infections in CGD patients may need to kill both intracellular and extracellular organisms. We studied the ability of certain antibiotics to penetrate normal and CGD neutrophils and to kill intracellular staphylococci. Trimethoprim and clindamycin were concentrated in normal and in CGD neutrophils; maximum cellular-to-extracellular concentration ratios of clindamycin and of trimethoprim were ∼30 and ∼4, respectively. In contrast, penicillin was excluded from normal neutrophils. Clindamycin, trimethoprim/sulfamethoxazole, rifampin, and trimethoprim/rifampin significantly reduced the number of viable intracellular staphylococci in normal and CGD neutrophils. After 24 h of incubation in the presence of these antibiotics, the number of viable intracellular staphylococci in normal and CGD neutrophils was similar. In contrast, dicloxacillin, gentamicin, and cephalothin had no significant effect on the number of intracellular staphylococci in normal or CGD neutrophils." @default.
- W1977862008 created "2016-06-24" @default.
- W1977862008 creator A5010573210 @default.
- W1977862008 creator A5065207317 @default.
- W1977862008 date "1983-11-01" @default.
- W1977862008 modified "2023-09-27" @default.
- W1977862008 title "Activity of Antibiotics in Chronic Granulomatous Disease Leukocytes" @default.
- W1977862008 doi "https://doi.org/10.1203/00006450-198311000-00016" @default.
- W1977862008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6646904" @default.
- W1977862008 hasPublicationYear "1983" @default.
- W1977862008 type Work @default.
- W1977862008 sameAs 1977862008 @default.
- W1977862008 citedByCount "27" @default.
- W1977862008 countsByYear W19778620082014 @default.
- W1977862008 countsByYear W19778620082018 @default.
- W1977862008 countsByYear W19778620082019 @default.
- W1977862008 countsByYear W19778620082020 @default.
- W1977862008 countsByYear W19778620082021 @default.
- W1977862008 countsByYear W19778620082022 @default.
- W1977862008 crossrefType "journal-article" @default.
- W1977862008 hasAuthorship W1977862008A5010573210 @default.
- W1977862008 hasAuthorship W1977862008A5065207317 @default.
- W1977862008 hasBestOaLocation W19778620081 @default.
- W1977862008 hasConcept C174802600 @default.
- W1977862008 hasConcept C203014093 @default.
- W1977862008 hasConcept C2775832221 @default.
- W1977862008 hasConcept C2776141307 @default.
- W1977862008 hasConcept C2777458120 @default.
- W1977862008 hasConcept C2778175462 @default.
- W1977862008 hasConcept C2779489039 @default.
- W1977862008 hasConcept C2780728791 @default.
- W1977862008 hasConcept C28406088 @default.
- W1977862008 hasConcept C501593827 @default.
- W1977862008 hasConcept C523546767 @default.
- W1977862008 hasConcept C54355233 @default.
- W1977862008 hasConcept C55493867 @default.
- W1977862008 hasConcept C79879829 @default.
- W1977862008 hasConcept C86803240 @default.
- W1977862008 hasConcept C89423630 @default.
- W1977862008 hasConceptScore W1977862008C174802600 @default.
- W1977862008 hasConceptScore W1977862008C203014093 @default.
- W1977862008 hasConceptScore W1977862008C2775832221 @default.
- W1977862008 hasConceptScore W1977862008C2776141307 @default.
- W1977862008 hasConceptScore W1977862008C2777458120 @default.
- W1977862008 hasConceptScore W1977862008C2778175462 @default.
- W1977862008 hasConceptScore W1977862008C2779489039 @default.
- W1977862008 hasConceptScore W1977862008C2780728791 @default.
- W1977862008 hasConceptScore W1977862008C28406088 @default.
- W1977862008 hasConceptScore W1977862008C501593827 @default.
- W1977862008 hasConceptScore W1977862008C523546767 @default.
- W1977862008 hasConceptScore W1977862008C54355233 @default.
- W1977862008 hasConceptScore W1977862008C55493867 @default.
- W1977862008 hasConceptScore W1977862008C79879829 @default.
- W1977862008 hasConceptScore W1977862008C86803240 @default.
- W1977862008 hasConceptScore W1977862008C89423630 @default.
- W1977862008 hasIssue "11" @default.
- W1977862008 hasLocation W19778620081 @default.
- W1977862008 hasLocation W19778620082 @default.
- W1977862008 hasOpenAccess W1977862008 @default.
- W1977862008 hasPrimaryLocation W19778620081 @default.
- W1977862008 hasRelatedWork W1977862008 @default.
- W1977862008 hasRelatedWork W2026176496 @default.
- W1977862008 hasRelatedWork W2027988616 @default.
- W1977862008 hasRelatedWork W2040543366 @default.
- W1977862008 hasRelatedWork W2070522405 @default.
- W1977862008 hasRelatedWork W2125076516 @default.
- W1977862008 hasRelatedWork W2142698632 @default.
- W1977862008 hasRelatedWork W2166909106 @default.
- W1977862008 hasRelatedWork W2315980083 @default.
- W1977862008 hasRelatedWork W2954251670 @default.
- W1977862008 hasVolume "17" @default.
- W1977862008 isParatext "false" @default.
- W1977862008 isRetracted "false" @default.
- W1977862008 magId "1977862008" @default.
- W1977862008 workType "article" @default.