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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977875932> ?p ?o ?g. }

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• W1977875932 abstract "With the aim to develop new potential 99mTc-radiopharmaceuticals for imaging hypoxia based on the formation of Tc-nitrido complexes, two novel dithiocarbamate containing metronidazole derivatives (L1 and L2) have been prepared and characterised. The synthesis of L1 and L2 was achieved in excellent yield and high purity. Labelling with 99mTc was successfully performed using a low ligand concentration (approximately 2–3 mg) and the desired products were obtained with high radiochemical purity (>90%). Lipophilicity, plasma protein binding, and biodistribution in normal- and tumour-bearing-CD1 mice studies were performed to asses the potentiality for nuclear medicine oncology. According to the physicochemical and biological behaviour both in healthy animals and in animals bearing solid tumours complex dtcTc1 could be considered as a starting point for the development of new radiopharmaceuticals for imaging hypoxia." @default.
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• W1977875932 date "2011-01-01" @default.
• W1977875932 modified "2023-10-18" @default.
• W1977875932 title "Synthesis and biological characterisation of novel dithiocarbamate containing 5-nitroimidazole 99mTc-complexes as potential agents for targeting hypoxia" @default.
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• W1977875932 doi "https://doi.org/10.1016/j.bmcl.2010.10.130" @default.
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