Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977877113> ?p ?o ?g. }
- W1977877113 endingPage "480" @default.
- W1977877113 startingPage "469" @default.
- W1977877113 abstract "It has been long proposed that exposure to environmental factors early in life may have an educating effect on the development of immune regulatory functions. However, experimental studies on this issue are limited and the related molecular and cellular basis remains unclear. Here we report that neonatal exposure to killed bacteria (Chlamydia muridarum, originally called Chlamydia trachomatis mouse pneumonitis (MoPn)) changed the pattern of the hosts' immune responses to a model allergen (OVA) in adulthood. This was associated with altered phenotype and function of DC. We found that DC from adult mice treated neonatally with UV-killed MoPn exhibited distinct patterns of surface marker and TLR expression and cytokine production from control mice (DC from adult mice neonatally treated with vehicle, (Sham-DC)). More importantly, DC from adult mice treated neonatally with UV-killed MoPn induced significantly lower type-2 antigen-specific T-cell responses than Sham-DC shown in DC:T co-culture experiments in vitro and in adoptive transfer experiments in vivo. In addition, depletion of T cells in vivo largely abolished the phenotypic and functional alterations of DC caused by bacterial exposure, suggesting the involvement of T cell in this process. Our study demonstrates a central role of DC in linking the early-life exposure to microbial products and the balanced development of immune regulatory functions and the involvement of T cells in imprinting of the DC function." @default.
- W1977877113 created "2016-06-24" @default.
- W1977877113 creator A5017110459 @default.
- W1977877113 creator A5020701449 @default.
- W1977877113 creator A5046231342 @default.
- W1977877113 creator A5060339946 @default.
- W1977877113 creator A5061439794 @default.
- W1977877113 creator A5071800448 @default.
- W1977877113 creator A5072038869 @default.
- W1977877113 date "2009-01-29" @default.
- W1977877113 modified "2023-09-28" @default.
- W1977877113 title "Imprinted DC mediate the immune-educating effect of early-life microbial exposure" @default.
- W1977877113 cites W1507248048 @default.
- W1977877113 cites W1532147512 @default.
- W1977877113 cites W1551964886 @default.
- W1977877113 cites W1574393433 @default.
- W1977877113 cites W1633927539 @default.
- W1977877113 cites W1653134186 @default.
- W1977877113 cites W1661697998 @default.
- W1977877113 cites W1718245819 @default.
- W1977877113 cites W1847683933 @default.
- W1977877113 cites W1965727970 @default.
- W1977877113 cites W1977607716 @default.
- W1977877113 cites W1979042193 @default.
- W1977877113 cites W1983140181 @default.
- W1977877113 cites W1985457155 @default.
- W1977877113 cites W2002071053 @default.
- W1977877113 cites W2004074099 @default.
- W1977877113 cites W2008947049 @default.
- W1977877113 cites W2009115082 @default.
- W1977877113 cites W2013349994 @default.
- W1977877113 cites W2017596644 @default.
- W1977877113 cites W2018173725 @default.
- W1977877113 cites W2029595418 @default.
- W1977877113 cites W2035043164 @default.
- W1977877113 cites W2035831689 @default.
- W1977877113 cites W2041589578 @default.
- W1977877113 cites W2042437855 @default.
- W1977877113 cites W2046212128 @default.
- W1977877113 cites W2047163370 @default.
- W1977877113 cites W2059674129 @default.
- W1977877113 cites W2070826289 @default.
- W1977877113 cites W2082266170 @default.
- W1977877113 cites W2098641823 @default.
- W1977877113 cites W2106888161 @default.
- W1977877113 cites W2108473659 @default.
- W1977877113 cites W2109958057 @default.
- W1977877113 cites W2113606216 @default.
- W1977877113 cites W2128519954 @default.
- W1977877113 cites W2137640965 @default.
- W1977877113 cites W2147770922 @default.
- W1977877113 cites W2151677607 @default.
- W1977877113 cites W2157324758 @default.
- W1977877113 cites W2157436384 @default.
- W1977877113 cites W2159112596 @default.
- W1977877113 cites W2161853794 @default.
- W1977877113 cites W2167745729 @default.
- W1977877113 doi "https://doi.org/10.1002/eji.200838367" @default.
- W1977877113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19180467" @default.
- W1977877113 hasPublicationYear "2009" @default.
- W1977877113 type Work @default.
- W1977877113 sameAs 1977877113 @default.
- W1977877113 citedByCount "22" @default.
- W1977877113 countsByYear W19778771132012 @default.
- W1977877113 countsByYear W19778771132013 @default.
- W1977877113 countsByYear W19778771132014 @default.
- W1977877113 countsByYear W19778771132015 @default.
- W1977877113 countsByYear W19778771132016 @default.
- W1977877113 countsByYear W19778771132017 @default.
- W1977877113 countsByYear W19778771132019 @default.
- W1977877113 countsByYear W19778771132021 @default.
- W1977877113 crossrefType "journal-article" @default.
- W1977877113 hasAuthorship W1977877113A5017110459 @default.
- W1977877113 hasAuthorship W1977877113A5020701449 @default.
- W1977877113 hasAuthorship W1977877113A5046231342 @default.
- W1977877113 hasAuthorship W1977877113A5060339946 @default.
- W1977877113 hasAuthorship W1977877113A5061439794 @default.
- W1977877113 hasAuthorship W1977877113A5071800448 @default.
- W1977877113 hasAuthorship W1977877113A5072038869 @default.
- W1977877113 hasBestOaLocation W19778771131 @default.
- W1977877113 hasConcept C104317684 @default.
- W1977877113 hasConcept C127716648 @default.
- W1977877113 hasConcept C147483822 @default.
- W1977877113 hasConcept C203014093 @default.
- W1977877113 hasConcept C207001950 @default.
- W1977877113 hasConcept C2776090121 @default.
- W1977877113 hasConcept C2777391075 @default.
- W1977877113 hasConcept C2778690821 @default.
- W1977877113 hasConcept C54355233 @default.
- W1977877113 hasConcept C86803240 @default.
- W1977877113 hasConcept C8891405 @default.
- W1977877113 hasConcept C90375314 @default.
- W1977877113 hasConcept C95444343 @default.
- W1977877113 hasConceptScore W1977877113C104317684 @default.
- W1977877113 hasConceptScore W1977877113C127716648 @default.
- W1977877113 hasConceptScore W1977877113C147483822 @default.
- W1977877113 hasConceptScore W1977877113C203014093 @default.
- W1977877113 hasConceptScore W1977877113C207001950 @default.