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- W1977878630 abstract "One of the major questions in the field of obesity is why some humans become obese (obesity prone, OP) and others resist the development of obesity (obesity resistant, OR) when exposed to a high-calorie diet, which has not been completely studied. Therefore, in the present study, in order to gain insight into the molecular mechanisms underlying this propensity, we have performed a comparative analysis of protein expression profiles in white adipose tissue (WAT) and brown adipose tissue (BAT) of rats fed a high-fat diet by 2-DE and MALDI-TOF-MS. Protein mapping of homogenates revealed significant alterations to a number of proteins; 60 and 70 proteins were differentially regulated in BAT and WAT, respectively. For careful interpretation of proteomic results, we categorized the identified proteins into two groups by analysis of both average spot density of pooled six rat adipose tissues and individual spot density of each adipose tissue of six rats as a function of body weight. One of the most striking findings of this study was that significant changes of Ehd1 and laminin receptor in BAT as well as antiquitin, DJ-1 protein, and paraoxonase 2 in WAT were found for the first time in obese rats. In addition, we confirmed the increased expression of some thermogenic enzymes and decreased lipogenic enzymes in adipose tissues of OR rats by immunoblot analysis. To our knowledge, this is the first proteomic study of profiling of protein modulation in OP and OR rats, thereby providing the first global evidence for different propensities to obesity between OP and OR rats." @default.
- W1977878630 created "2016-06-24" @default.
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- W1977878630 creator A5056917920 @default.
- W1977878630 creator A5079655788 @default.
- W1977878630 creator A5080250415 @default.
- W1977878630 date "2011-02-25" @default.
- W1977878630 modified "2023-10-18" @default.
- W1977878630 title "Differential expression of adipose tissue proteins between obesity-susceptible and -resistant rats fed a high-fat diet" @default.
- W1977878630 cites W1493035598 @default.
- W1977878630 cites W1561328546 @default.
- W1977878630 cites W1580746914 @default.
- W1977878630 cites W1811350936 @default.
- W1977878630 cites W1849928642 @default.
- W1977878630 cites W1854936925 @default.
- W1977878630 cites W1940103863 @default.
- W1977878630 cites W1963643013 @default.
- W1977878630 cites W1963792814 @default.
- W1977878630 cites W1964416938 @default.
- W1977878630 cites W1967008795 @default.
- W1977878630 cites W1968449984 @default.
- W1977878630 cites W1968460529 @default.
- W1977878630 cites W1969099489 @default.
- W1977878630 cites W1973396761 @default.
- W1977878630 cites W1975258346 @default.
- W1977878630 cites W1984755144 @default.
- W1977878630 cites W1986375719 @default.
- W1977878630 cites W1987578739 @default.
- W1977878630 cites W1989711390 @default.
- W1977878630 cites W1990847293 @default.
- W1977878630 cites W1991366673 @default.
- W1977878630 cites W1994227492 @default.
- W1977878630 cites W1994849711 @default.
- W1977878630 cites W2000464737 @default.
- W1977878630 cites W2002962229 @default.
- W1977878630 cites W2003180539 @default.
- W1977878630 cites W2010178137 @default.
- W1977878630 cites W2011300705 @default.
- W1977878630 cites W2014697141 @default.
- W1977878630 cites W2015355519 @default.
- W1977878630 cites W2019524734 @default.
- W1977878630 cites W2020693481 @default.
- W1977878630 cites W2022614975 @default.
- W1977878630 cites W2024923170 @default.
- W1977878630 cites W2025487501 @default.
- W1977878630 cites W2026167664 @default.
- W1977878630 cites W2032814494 @default.
- W1977878630 cites W2042673633 @default.
- W1977878630 cites W2045619830 @default.
- W1977878630 cites W2052211299 @default.
- W1977878630 cites W2056082588 @default.
- W1977878630 cites W2058030471 @default.
- W1977878630 cites W2060570579 @default.
- W1977878630 cites W2066912578 @default.
- W1977878630 cites W2067403820 @default.
- W1977878630 cites W2068880845 @default.
- W1977878630 cites W2070543019 @default.
- W1977878630 cites W2071573024 @default.
- W1977878630 cites W2072649045 @default.
- W1977878630 cites W2076196975 @default.
- W1977878630 cites W2076499590 @default.
- W1977878630 cites W2079757668 @default.
- W1977878630 cites W2080857749 @default.
- W1977878630 cites W2088495902 @default.
- W1977878630 cites W2088986234 @default.
- W1977878630 cites W2089524428 @default.
- W1977878630 cites W2089771325 @default.
- W1977878630 cites W2091852463 @default.
- W1977878630 cites W2092823267 @default.
- W1977878630 cites W2097612997 @default.
- W1977878630 cites W2097879976 @default.
- W1977878630 cites W2099040294 @default.
- W1977878630 cites W2104139918 @default.
- W1977878630 cites W2104324197 @default.
- W1977878630 cites W2104385322 @default.
- W1977878630 cites W2106693109 @default.
- W1977878630 cites W2107212460 @default.
- W1977878630 cites W2110738761 @default.
- W1977878630 cites W2113617470 @default.
- W1977878630 cites W2114040653 @default.
- W1977878630 cites W2125857619 @default.
- W1977878630 cites W2132485471 @default.
- W1977878630 cites W2133837686 @default.
- W1977878630 cites W2136638803 @default.
- W1977878630 cites W2139398286 @default.
- W1977878630 cites W2139431079 @default.
- W1977878630 cites W2141452792 @default.
- W1977878630 cites W2144783460 @default.
- W1977878630 cites W2147821881 @default.
- W1977878630 cites W2148249718 @default.
- W1977878630 cites W2153321120 @default.
- W1977878630 cites W2156533174 @default.
- W1977878630 cites W2158905604 @default.
- W1977878630 cites W2167825438 @default.
- W1977878630 cites W2168132477 @default.