FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977883749> ?p ?o ?g. }

• W1977883749 endingPage "3830" @default.
• W1977883749 startingPage "3817" @default.
• W1977883749 abstract "In drug development, Caco-2 cells are often employed to study the influence of membrane transporters on drug permeability. The aim of the current study was to characterize permeability and kinetic parameters of selected organic anionic compounds in Caco-2 cells, and to investigate whether the Caco-2 cell line may be used as an overall model to predict interactions on multiple membrane transporters in the intestine. Taurocholic acid (TCA) and estrone-3-sulfate (E1S) were used as model substrates. Possible inhibitors studied were TCA, E1S, taurolithocholic acid, fluvastatin, and glipizide. The effects of these compounds on initial uptake, apparent permeability, and intracellular end-point accumulations of the probe substrates were studied. Both interactions on apical and basolateral influx transporters were observed. These interactions were proposed to be mediated mainly by the apical sodium-dependent bile acid transporter and the organic solute transporter α/β, and to less extent by the organic anion transporting polypeptide 2B1. However, interactions on efflux transporters were not detected, although they were expected from the literature on the investigated compounds. Biosimulation methods may be the key to further distinguish between interactions on multiple transporters, including the involvement of efflux transporters, by taking into account the changes in dynamics that drug interactions may cause. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3817–3830, 2011" @default.
• W1977883749 created "2016-06-24" @default.
• W1977883749 creator A5040234344 @default.
• W1977883749 creator A5062639162 @default.
• W1977883749 date "2011-09-01" @default.
• W1977883749 modified "2023-09-30" @default.
• W1977883749 title "Interactions Between Organic Anions on Multiple Transporters in Caco-2 Cells" @default.
• W1977883749 cites W1564906832 @default.
• W1977883749 cites W1580386589 @default.
• W1977883749 cites W1904678284 @default.
• W1977883749 cites W1965585024 @default.
• W1977883749 cites W1965712862 @default.
• W1977883749 cites W1967806967 @default.
• W1977883749 cites W1970359870 @default.
• W1977883749 cites W1978224396 @default.
• W1977883749 cites W1981795574 @default.
• W1977883749 cites W1984613701 @default.
• W1977883749 cites W1994470556 @default.
• W1977883749 cites W1995526845 @default.
• W1977883749 cites W1999004536 @default.
• W1977883749 cites W2003334133 @default.
• W1977883749 cites W2006807155 @default.
• W1977883749 cites W2007705439 @default.
• W1977883749 cites W2008077160 @default.
• W1977883749 cites W2014283537 @default.
• W1977883749 cites W2023648745 @default.
• W1977883749 cites W2028444358 @default.
• W1977883749 cites W2035406215 @default.
• W1977883749 cites W2038606604 @default.
• W1977883749 cites W2040628852 @default.
• W1977883749 cites W2041471580 @default.
• W1977883749 cites W2042745755 @default.
• W1977883749 cites W2046320522 @default.
• W1977883749 cites W2060917067 @default.
• W1977883749 cites W2061734023 @default.
• W1977883749 cites W2062577889 @default.
• W1977883749 cites W2079197876 @default.
• W1977883749 cites W2079259464 @default.
• W1977883749 cites W2081126191 @default.
• W1977883749 cites W2083340291 @default.
• W1977883749 cites W2084375116 @default.
• W1977883749 cites W2093259035 @default.
• W1977883749 cites W2118355203 @default.
• W1977883749 cites W2123699472 @default.
• W1977883749 cites W2126348132 @default.
• W1977883749 cites W2132503235 @default.
• W1977883749 cites W2140065347 @default.
• W1977883749 cites W2142024216 @default.
• W1977883749 cites W2146829250 @default.
• W1977883749 cites W2147787974 @default.
• W1977883749 cites W2148070209 @default.
• W1977883749 cites W2161215121 @default.
• W1977883749 cites W2165711991 @default.
• W1977883749 cites W2167145816 @default.
• W1977883749 cites W2167450468 @default.
• W1977883749 cites W2171070582 @default.
• W1977883749 cites W37415236 @default.
• W1977883749 doi "https://doi.org/10.1002/jps.22632" @default.
• W1977883749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21607956" @default.
• W1977883749 hasPublicationYear "2011" @default.
• W1977883749 type Work @default.
• W1977883749 sameAs 1977883749 @default.
• W1977883749 citedByCount "16" @default.
• W1977883749 countsByYear W19778837492012 @default.
• W1977883749 countsByYear W19778837492013 @default.
• W1977883749 countsByYear W19778837492014 @default.
• W1977883749 countsByYear W19778837492015 @default.
• W1977883749 countsByYear W19778837492016 @default.
• W1977883749 countsByYear W19778837492017 @default.
• W1977883749 countsByYear W19778837492018 @default.
• W1977883749 countsByYear W19778837492019 @default.
• W1977883749 countsByYear W19778837492020 @default.
• W1977883749 countsByYear W19778837492021 @default.
• W1977883749 countsByYear W19778837492023 @default.
• W1977883749 crossrefType "journal-article" @default.
• W1977883749 hasAuthorship W1977883749A5040234344 @default.
• W1977883749 hasAuthorship W1977883749A5062639162 @default.
• W1977883749 hasBestOaLocation W19778837491 @default.
• W1977883749 hasConcept C104317684 @default.
• W1977883749 hasConcept C123584848 @default.
• W1977883749 hasConcept C12554922 @default.
• W1977883749 hasConcept C149011108 @default.
• W1977883749 hasConcept C1491633281 @default.
• W1977883749 hasConcept C185592680 @default.
• W1977883749 hasConcept C189613389 @default.
• W1977883749 hasConcept C193176779 @default.
• W1977883749 hasConcept C200082930 @default.
• W1977883749 hasConcept C2776678969 @default.
• W1977883749 hasConcept C2779399885 @default.
• W1977883749 hasConcept C2780480987 @default.
• W1977883749 hasConcept C30448527 @default.
• W1977883749 hasConcept C41625074 @default.
• W1977883749 hasConcept C44312359 @default.
• W1977883749 hasConcept C512196 @default.
• W1977883749 hasConcept C55493867 @default.
• W1977883749 hasConcept C79879829 @default.
• W1977883749 hasConcept C86803240 @default.
• W1977883749 hasConceptScore W1977883749C104317684 @default.

• next