FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977886543> ?p ?o ?g. }

• W1977886543 endingPage "1431" @default.
• W1977886543 startingPage "1425" @default.
• W1977886543 abstract "Purpose To report toxicity, local control, enucleation, and survival rates for patients with peripapillary choroidal melanoma treated with proton therapy in Canada. Methods and Materials We performed a retrospective analysis of patients with peripapillary choroidal melanoma (≤2 mm from optic disc) treated between 1995 and 2007 at the only Canadian proton therapy facility. A prospective database was updated for follow-up information from a chart review. Descriptive and actuarial data are presented. Results In total, 59 patients were treated. The median age was 59 years. According to the 2010 American Joint Committee on Cancer TNM classification, there were 20 T1 tumors (34%), 28 T2 tumors (48%), and 11 T3 tumors (19%). The median tumor diameter was 11.4 mm, and the median thickness was 3.5 mm. Median follow-up was 63 months. Nineteen patients received 54 cobalt gray equivalents (CGE) and forty patients received 60 CGE, each in 4 fractions. The 5-year actuarial local control rate was 91% (T1, 100%; T2, 93%; and T3, 59%) (p = 0.038). There was a suggestive relationship between local control and dose. The local control rate was 97% with 60 CGE and 83% with 54 CGE (p = 0.106). The metastasis-free survival rate was 82% and related to T stage (T1, 94%; T2, 84%; and T3, 47%) (p < 0.001). Twelve patients died, including eleven with metastases. The 5-year actuarial rate of neovascular glaucoma was 31% (23% for T1–T2 and 68% for T3, p < 0.001), and that of enucleation was 0% for T1, 14% for T2, and 72% for T3 (p < 0.001). Radiation retinopathy (74%) and optic neuropathy (64%) were common within-field effects. Conclusions Proton therapy provides excellent local control with acceptable toxicity while conserving the globe in 80% of cases. These results are consistent with other single-institution series using proton radiotherapy, and toxicity rates were acceptable. T3 tumors carry a higher rate of both local recurrence and metastasis. To report toxicity, local control, enucleation, and survival rates for patients with peripapillary choroidal melanoma treated with proton therapy in Canada. We performed a retrospective analysis of patients with peripapillary choroidal melanoma (≤2 mm from optic disc) treated between 1995 and 2007 at the only Canadian proton therapy facility. A prospective database was updated for follow-up information from a chart review. Descriptive and actuarial data are presented. In total, 59 patients were treated. The median age was 59 years. According to the 2010 American Joint Committee on Cancer TNM classification, there were 20 T1 tumors (34%), 28 T2 tumors (48%), and 11 T3 tumors (19%). The median tumor diameter was 11.4 mm, and the median thickness was 3.5 mm. Median follow-up was 63 months. Nineteen patients received 54 cobalt gray equivalents (CGE) and forty patients received 60 CGE, each in 4 fractions. The 5-year actuarial local control rate was 91% (T1, 100%; T2, 93%; and T3, 59%) (p = 0.038). There was a suggestive relationship between local control and dose. The local control rate was 97% with 60 CGE and 83% with 54 CGE (p = 0.106). The metastasis-free survival rate was 82% and related to T stage (T1, 94%; T2, 84%; and T3, 47%) (p < 0.001). Twelve patients died, including eleven with metastases. The 5-year actuarial rate of neovascular glaucoma was 31% (23% for T1–T2 and 68% for T3, p < 0.001), and that of enucleation was 0% for T1, 14% for T2, and 72% for T3 (p < 0.001). Radiation retinopathy (74%) and optic neuropathy (64%) were common within-field effects. Proton therapy provides excellent local control with acceptable toxicity while conserving the globe in 80% of cases. These results are consistent with other single-institution series using proton radiotherapy, and toxicity rates were acceptable. T3 tumors carry a higher rate of both local recurrence and metastasis." @default.
• W1977886543 created "2016-06-24" @default.
• W1977886543 creator A5006548536 @default.
• W1977886543 creator A5012748950 @default.
• W1977886543 creator A5059799295 @default.
• W1977886543 creator A5070464513 @default.
• W1977886543 creator A5080709444 @default.
• W1977886543 date "2012-08-01" @default.
• W1977886543 modified "2023-10-14" @default.
• W1977886543 title "Outcomes of Proton Radiation Therapy for Peripapillary Choroidal Melanoma at the BC Cancer Agency" @default.
• W1977886543 cites W1974606008 @default.
• W1977886543 cites W1979332028 @default.
• W1977886543 cites W1979505363 @default.
• W1977886543 cites W1987925102 @default.
• W1977886543 cites W1989860293 @default.
• W1977886543 cites W2001707539 @default.
• W1977886543 cites W2013981048 @default.
• W1977886543 cites W2018032989 @default.
• W1977886543 cites W2018784809 @default.
• W1977886543 cites W2022921829 @default.
• W1977886543 cites W2034346103 @default.
• W1977886543 cites W2042993075 @default.
• W1977886543 cites W2058109454 @default.
• W1977886543 cites W2059915516 @default.
• W1977886543 cites W2065543327 @default.
• W1977886543 cites W2071696483 @default.
• W1977886543 cites W2071951164 @default.
• W1977886543 cites W2107109105 @default.
• W1977886543 cites W2121662622 @default.
• W1977886543 cites W2127644935 @default.
• W1977886543 cites W2133924016 @default.
• W1977886543 cites W2562156357 @default.
• W1977886543 cites W65135050 @default.
• W1977886543 cites W71869676 @default.
• W1977886543 doi "https://doi.org/10.1016/j.ijrobp.2011.10.017" @default.
• W1977886543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22209152" @default.
• W1977886543 hasPublicationYear "2012" @default.
• W1977886543 type Work @default.
• W1977886543 sameAs 1977886543 @default.
• W1977886543 citedByCount "32" @default.
• W1977886543 countsByYear W19778865432012 @default.
• W1977886543 countsByYear W19778865432013 @default.
• W1977886543 countsByYear W19778865432014 @default.
• W1977886543 countsByYear W19778865432015 @default.
• W1977886543 countsByYear W19778865432016 @default.
• W1977886543 countsByYear W19778865432017 @default.
• W1977886543 countsByYear W19778865432018 @default.
• W1977886543 countsByYear W19778865432019 @default.
• W1977886543 countsByYear W19778865432020 @default.
• W1977886543 countsByYear W19778865432021 @default.
• W1977886543 countsByYear W19778865432023 @default.
• W1977886543 crossrefType "journal-article" @default.
• W1977886543 hasAuthorship W1977886543A5006548536 @default.
• W1977886543 hasAuthorship W1977886543A5012748950 @default.
• W1977886543 hasAuthorship W1977886543A5059799295 @default.
• W1977886543 hasAuthorship W1977886543A5070464513 @default.
• W1977886543 hasAuthorship W1977886543A5080709444 @default.
• W1977886543 hasConcept C118487528 @default.
• W1977886543 hasConcept C141071460 @default.
• W1977886543 hasConcept C146357865 @default.
• W1977886543 hasConcept C151730666 @default.
• W1977886543 hasConcept C188261085 @default.
• W1977886543 hasConcept C2777658100 @default.
• W1977886543 hasConcept C3019556204 @default.
• W1977886543 hasConcept C502942594 @default.
• W1977886543 hasConcept C509974204 @default.
• W1977886543 hasConcept C71924100 @default.
• W1977886543 hasConcept C86803240 @default.
• W1977886543 hasConceptScore W1977886543C118487528 @default.
• W1977886543 hasConceptScore W1977886543C141071460 @default.
• W1977886543 hasConceptScore W1977886543C146357865 @default.
• W1977886543 hasConceptScore W1977886543C151730666 @default.
• W1977886543 hasConceptScore W1977886543C188261085 @default.
• W1977886543 hasConceptScore W1977886543C2777658100 @default.
• W1977886543 hasConceptScore W1977886543C3019556204 @default.
• W1977886543 hasConceptScore W1977886543C502942594 @default.
• W1977886543 hasConceptScore W1977886543C509974204 @default.
• W1977886543 hasConceptScore W1977886543C71924100 @default.
• W1977886543 hasConceptScore W1977886543C86803240 @default.
• W1977886543 hasIssue "5" @default.
• W1977886543 hasLocation W19778865431 @default.
• W1977886543 hasLocation W19778865432 @default.
• W1977886543 hasOpenAccess W1977886543 @default.
• W1977886543 hasPrimaryLocation W19778865431 @default.
• W1977886543 hasRelatedWork W1991916871 @default.
• W1977886543 hasRelatedWork W2015912928 @default.
• W1977886543 hasRelatedWork W2025456110 @default.
• W1977886543 hasRelatedWork W2042979126 @default.
• W1977886543 hasRelatedWork W2067210526 @default.
• W1977886543 hasRelatedWork W2083495678 @default.
• W1977886543 hasRelatedWork W2096196853 @default.
• W1977886543 hasRelatedWork W2463706577 @default.
• W1977886543 hasRelatedWork W3157064990 @default.
• W1977886543 hasRelatedWork W3112594934 @default.
• W1977886543 hasVolume "83" @default.
• W1977886543 isParatext "false" @default.
• W1977886543 isRetracted "false" @default.
• W1977886543 magId "1977886543" @default.

• next