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• W1977890271 abstract "A new approach to the synthesis of 2-fluoro-2-deoxy-D-glucose (FDG, [19/18F]-3) is described, which employs supported perfluoroalkylsulfonate precursors 33–36, where the support consists of insoluble polystyrene resin beads. Treatment of these resins with [19F]fluoride ion afforded protected FDG [19F]-18 as the major product, and the identities of the main byproducts were determined. Acidic removal of the acetal protecting groups from [19F]-18 was shown to produce [19F]FDG. The method has been applied to the efficient radiosynthesis of the imaging agent [18F]FDG, and was shown to produce the radiochemical tracer in good radiochemical yield (average 73%, decay corrected)." @default.
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• W1977890271 date "2009-01-01" @default.
• W1977890271 modified "2023-09-25" @default.
• W1977890271 title "Synthesis of the positron-emitting radiotracer [¹⁸F]-2-fluoro-2-deoxy-<scp>d</scp>-glucose from resin-bound perfluoroalkylsulfonates" @default.
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• W1977890271 doi "https://doi.org/10.1039/b816032e" @default.
• W1977890271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19156324" @default.
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