FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977891655> ?p ?o ?g. }

• W1977891655 endingPage "63" @default.
• W1977891655 startingPage "55" @default.
• W1977891655 abstract "The anticancer efficacy of ursolic acid (UA) was limited by poor water solubility, non-specific tumor distribution, and low bioavailability. To overcome this problem, polyamidoamine (PAMAM) conjugated with UA and folic acid (FA) as novel dendrimeric prodrugs were designed and successfully synthesized by a concise one-pot synthetic approach. Both FA and UA were covalently conjugated to the surface of PAMAM through acid-labile ester bonds and the covalently linked UA could be hydrolysed either in acidic (pH 5.4) or in neutral (pH 7.4) PBS solution. The cellular uptake study indicated that the presence of FA enhanced uptake of the dendrimeric prodrugs in folate receptor (FR) over-expressing Hela cells. The enhanced cellular uptake could be due to the electrostatic absorptive endocytosis and FR-mediated endocytosis. In contrast, for HepG2 cells, a FR-negative cell line, FA conjugation on the surface of the dendrimer showed no effect on the cellular uptake. In MTT assay and cell cycle analysis, FA-modified dendrimeric prodrugs showed significantly enhanced toxicity than non-FA-modified ones in Hela cells. These results suggested that FA-modified dendrimeric UA prodrugs have the potential for targeted delivery of UA into cancer cells to improve its anti-tumor efficacy." @default.
• W1977891655 created "2016-06-24" @default.
• W1977891655 creator A5008549662 @default.
• W1977891655 creator A5015152680 @default.
• W1977891655 creator A5028837168 @default.
• W1977891655 creator A5042194405 @default.
• W1977891655 creator A5045019377 @default.
• W1977891655 creator A5054103732 @default.
• W1977891655 creator A5066552817 @default.
• W1977891655 creator A5077681133 @default.
• W1977891655 creator A5078888279 @default.
• W1977891655 creator A5086261636 @default.
• W1977891655 creator A5091074428 @default.
• W1977891655 date "2015-04-01" @default.
• W1977891655 modified "2023-10-18" @default.
• W1977891655 title "Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate receptor-expressing cancer cells: Synthesis and biological evaluation" @default.
• W1977891655 cites W1971848312 @default.
• W1977891655 cites W1976442101 @default.
• W1977891655 cites W1977132276 @default.
• W1977891655 cites W1978267970 @default.
• W1977891655 cites W1978792402 @default.
• W1977891655 cites W2002156365 @default.
• W1977891655 cites W2003265402 @default.
• W1977891655 cites W2013983587 @default.
• W1977891655 cites W2019207861 @default.
• W1977891655 cites W2033627762 @default.
• W1977891655 cites W2043077780 @default.
• W1977891655 cites W2046517307 @default.
• W1977891655 cites W2050736248 @default.
• W1977891655 cites W2054206985 @default.
• W1977891655 cites W2060279237 @default.
• W1977891655 cites W2069126054 @default.
• W1977891655 cites W2070558800 @default.
• W1977891655 cites W2071932243 @default.
• W1977891655 cites W2072952339 @default.
• W1977891655 cites W2074599278 @default.
• W1977891655 cites W2089086593 @default.
• W1977891655 cites W2097007428 @default.
• W1977891655 cites W2100065903 @default.
• W1977891655 cites W2104968568 @default.
• W1977891655 cites W2119099023 @default.
• W1977891655 cites W2120260995 @default.
• W1977891655 cites W2136365615 @default.
• W1977891655 cites W2145010618 @default.
• W1977891655 cites W2145630289 @default.
• W1977891655 cites W2157073440 @default.
• W1977891655 cites W2161379608 @default.
• W1977891655 cites W2334019335 @default.
• W1977891655 doi "https://doi.org/10.1016/j.ejps.2015.01.007" @default.
• W1977891655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25638419" @default.
• W1977891655 hasPublicationYear "2015" @default.
• W1977891655 type Work @default.
• W1977891655 sameAs 1977891655 @default.
• W1977891655 citedByCount "61" @default.
• W1977891655 countsByYear W19778916552015 @default.
• W1977891655 countsByYear W19778916552016 @default.
• W1977891655 countsByYear W19778916552017 @default.
• W1977891655 countsByYear W19778916552018 @default.
• W1977891655 countsByYear W19778916552019 @default.
• W1977891655 countsByYear W19778916552020 @default.
• W1977891655 countsByYear W19778916552021 @default.
• W1977891655 countsByYear W19778916552022 @default.
• W1977891655 countsByYear W19778916552023 @default.
• W1977891655 crossrefType "journal-article" @default.
• W1977891655 hasAuthorship W1977891655A5008549662 @default.
• W1977891655 hasAuthorship W1977891655A5015152680 @default.
• W1977891655 hasAuthorship W1977891655A5028837168 @default.
• W1977891655 hasAuthorship W1977891655A5042194405 @default.
• W1977891655 hasAuthorship W1977891655A5045019377 @default.
• W1977891655 hasAuthorship W1977891655A5054103732 @default.
• W1977891655 hasAuthorship W1977891655A5066552817 @default.
• W1977891655 hasAuthorship W1977891655A5077681133 @default.
• W1977891655 hasAuthorship W1977891655A5078888279 @default.
• W1977891655 hasAuthorship W1977891655A5086261636 @default.
• W1977891655 hasAuthorship W1977891655A5091074428 @default.
• W1977891655 hasConcept C108215921 @default.
• W1977891655 hasConcept C121608353 @default.
• W1977891655 hasConcept C1491633281 @default.
• W1977891655 hasConcept C178790620 @default.
• W1977891655 hasConcept C180577832 @default.
• W1977891655 hasConcept C181389837 @default.
• W1977891655 hasConcept C185592680 @default.
• W1977891655 hasConcept C2777366897 @default.
• W1977891655 hasConcept C2780306303 @default.
• W1977891655 hasConcept C28005876 @default.
• W1977891655 hasConcept C54355233 @default.
• W1977891655 hasConcept C55493867 @default.
• W1977891655 hasConcept C55637122 @default.
• W1977891655 hasConcept C86803240 @default.
• W1977891655 hasConcept C96232424 @default.
• W1977891655 hasConcept C98274493 @default.
• W1977891655 hasConceptScore W1977891655C108215921 @default.
• W1977891655 hasConceptScore W1977891655C121608353 @default.
• W1977891655 hasConceptScore W1977891655C1491633281 @default.
• W1977891655 hasConceptScore W1977891655C178790620 @default.
• W1977891655 hasConceptScore W1977891655C180577832 @default.
• W1977891655 hasConceptScore W1977891655C181389837 @default.
• W1977891655 hasConceptScore W1977891655C185592680 @default.

• next