Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977908579> ?p ?o ?g. }
- W1977908579 endingPage "1883" @default.
- W1977908579 startingPage "1873" @default.
- W1977908579 abstract "Cell adhesion plays an important role in the steps of cancer metastasis. Regulation of cell–cell (intercellular) and cell–matrix adhesion is a promising strategy for cancer progression. Gambogic acid is a xanthone derived from the resin of the Chinese plant Garciania hanburyi, with potent anti-metastasis activity on highly metastatic cells. The aim of this study was to investigate the function and mechanism of gambogic acid on tumor adhesion. We found that gambogic acid strongly inhibited the adhesion of human cancer cells to fibronectin. This inhibition was associated with the deformation of focal adhesion complex, which was mediated by suppressing the expression of integrin β1 and integrin signaling pathway. In vitro, cell lipid rafts clustering was inhibited following treatment of gambogic acid, which induced the suppression of integrin β1 and focal adhesion complex proteins colocalization within rafts. Moreover, gambogic acid significantly decreased cellular cholesterol content, whereas cholesterol replenishment lessened the inhibitory effect of gambogic acid on cell adhesion. Real-time PCR analysis showed that gambogic acid reduced mRNA levels of hydroxymethylglutaryl-CoA reductase and sterol regulatory element binding protein-2, while increased acetyl-CoA acetyltransferase-1/2. Taken together, these results demonstrate that gambogic acid inhibits cell adhesion via suppressing integrin β1 abundance and cholesterol content as well as the membrane lipid raft-associated integrin function, which provide new evidence for the anti-cancer activity of gambogic acid." @default.
- W1977908579 created "2016-06-24" @default.
- W1977908579 creator A5035643059 @default.
- W1977908579 creator A5037121594 @default.
- W1977908579 creator A5037458498 @default.
- W1977908579 creator A5041422262 @default.
- W1977908579 creator A5045085415 @default.
- W1977908579 creator A5045934445 @default.
- W1977908579 creator A5051829452 @default.
- W1977908579 creator A5055086087 @default.
- W1977908579 creator A5055561636 @default.
- W1977908579 creator A5082508377 @default.
- W1977908579 creator A5083151551 @default.
- W1977908579 date "2011-12-01" @default.
- W1977908579 modified "2023-10-15" @default.
- W1977908579 title "Gambogic acid inhibits tumor cell adhesion by suppressing integrin β1 and membrane lipid rafts-associated integrin signaling pathway" @default.
- W1977908579 cites W137677171 @default.
- W1977908579 cites W1533747850 @default.
- W1977908579 cites W1938835738 @default.
- W1977908579 cites W1975069567 @default.
- W1977908579 cites W1977253905 @default.
- W1977908579 cites W1982323848 @default.
- W1977908579 cites W1983997975 @default.
- W1977908579 cites W1986849641 @default.
- W1977908579 cites W1988706652 @default.
- W1977908579 cites W1991849091 @default.
- W1977908579 cites W1998811052 @default.
- W1977908579 cites W2003366243 @default.
- W1977908579 cites W2012953879 @default.
- W1977908579 cites W2015539246 @default.
- W1977908579 cites W2024059382 @default.
- W1977908579 cites W2031046412 @default.
- W1977908579 cites W2034407136 @default.
- W1977908579 cites W2038327848 @default.
- W1977908579 cites W2047765160 @default.
- W1977908579 cites W2048971924 @default.
- W1977908579 cites W2049830786 @default.
- W1977908579 cites W2056190420 @default.
- W1977908579 cites W2058170261 @default.
- W1977908579 cites W2065875929 @default.
- W1977908579 cites W2073280063 @default.
- W1977908579 cites W2075555706 @default.
- W1977908579 cites W2080088868 @default.
- W1977908579 cites W2084867085 @default.
- W1977908579 cites W2085412371 @default.
- W1977908579 cites W2086435807 @default.
- W1977908579 cites W2086996769 @default.
- W1977908579 cites W2091719398 @default.
- W1977908579 cites W2101244168 @default.
- W1977908579 cites W2113263416 @default.
- W1977908579 cites W2114270638 @default.
- W1977908579 cites W2114858260 @default.
- W1977908579 cites W2115037258 @default.
- W1977908579 cites W2116805516 @default.
- W1977908579 cites W2118280014 @default.
- W1977908579 cites W2123964347 @default.
- W1977908579 cites W2128891409 @default.
- W1977908579 cites W2136339421 @default.
- W1977908579 cites W2136558879 @default.
- W1977908579 cites W2139066240 @default.
- W1977908579 cites W2145842550 @default.
- W1977908579 cites W2151856952 @default.
- W1977908579 cites W2152311269 @default.
- W1977908579 cites W2154313522 @default.
- W1977908579 cites W2158862003 @default.
- W1977908579 cites W2160621618 @default.
- W1977908579 cites W2168386853 @default.
- W1977908579 cites W2332938407 @default.
- W1977908579 cites W2953132897 @default.
- W1977908579 cites W4213141530 @default.
- W1977908579 cites W4253642967 @default.
- W1977908579 doi "https://doi.org/10.1016/j.bcp.2011.09.013" @default.
- W1977908579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21946083" @default.
- W1977908579 hasPublicationYear "2011" @default.
- W1977908579 type Work @default.
- W1977908579 sameAs 1977908579 @default.
- W1977908579 citedByCount "54" @default.
- W1977908579 countsByYear W19779085792012 @default.
- W1977908579 countsByYear W19779085792013 @default.
- W1977908579 countsByYear W19779085792014 @default.
- W1977908579 countsByYear W19779085792015 @default.
- W1977908579 countsByYear W19779085792016 @default.
- W1977908579 countsByYear W19779085792017 @default.
- W1977908579 countsByYear W19779085792018 @default.
- W1977908579 countsByYear W19779085792019 @default.
- W1977908579 countsByYear W19779085792020 @default.
- W1977908579 countsByYear W19779085792021 @default.
- W1977908579 countsByYear W19779085792022 @default.
- W1977908579 countsByYear W19779085792023 @default.
- W1977908579 crossrefType "journal-article" @default.
- W1977908579 hasAuthorship W1977908579A5035643059 @default.
- W1977908579 hasAuthorship W1977908579A5037121594 @default.
- W1977908579 hasAuthorship W1977908579A5037458498 @default.
- W1977908579 hasAuthorship W1977908579A5041422262 @default.
- W1977908579 hasAuthorship W1977908579A5045085415 @default.
- W1977908579 hasAuthorship W1977908579A5045934445 @default.
- W1977908579 hasAuthorship W1977908579A5051829452 @default.
- W1977908579 hasAuthorship W1977908579A5055086087 @default.