Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977915772> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1977915772 endingPage "31" @default.
- W1977915772 startingPage "21" @default.
- W1977915772 abstract "Side reactions following ivermectin treatment were evaluated in sixty males with high density bancroftian microfilaremia (GM 1388/ml). Following a single oral dose of ivermectin of different strengths (20, 50, 100 or 200 micrograms/kg), microfilariae clearance and side reactions were monitored in a double blind fashion. Microfilaria levels fell rapidly after ivermectin administration in all dosage groups and 98% of pretreatment microfilariae was cleared after 12 h of treatment. The rate of microfilaria (mf) clearance was slower with 20 micrograms/kg than with the highest dose (200 micrograms/kg) administered. Forty-six patients (77%) became amicrofilaraemic within 2 weeks of treatment. Side reactions were noted in 97% of cases. The most common reactions were fever, headache, weakness, myalgia and cough which appeared by 12 h and subsided by 72 h following treatment. The frequency and intensity of side reactions were related to pretreatment mf densities and were independent of the dose administered. Unusual side reactions were noted in a few patients with high density microfilaraemia. These included intense cough, shortness of breath, blood tinged mucoid expectoration associated with patchy pneumonitis of the lung. Itchy rashes, lymphatic nodules and raised alkaline phosphatase level were also observed in some patients. These side reactions were transient, self limiting and were not serious enough to warrant any treatment. These exaggerated unusual reactions were possibly due to allergic response of the susceptible host to rapid killing of large number of microfilariae." @default.
- W1977915772 created "2016-06-24" @default.
- W1977915772 creator A5030793401 @default.
- W1977915772 creator A5040012220 @default.
- W1977915772 creator A5061118106 @default.
- W1977915772 creator A5081813581 @default.
- W1977915772 date "1993-10-01" @default.
- W1977915772 modified "2023-09-27" @default.
- W1977915772 title "Side reactions following ivermectin therapy in high density bancroftian microfilaraemics" @default.
- W1977915772 cites W1964870042 @default.
- W1977915772 cites W1979827598 @default.
- W1977915772 cites W1989064596 @default.
- W1977915772 cites W2014435050 @default.
- W1977915772 cites W2015906739 @default.
- W1977915772 cites W2042741849 @default.
- W1977915772 cites W2056096733 @default.
- W1977915772 cites W2064959067 @default.
- W1977915772 cites W2463005588 @default.
- W1977915772 cites W2472970617 @default.
- W1977915772 cites W4298191095 @default.
- W1977915772 doi "https://doi.org/10.1016/0001-706x(93)90045-d" @default.
- W1977915772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7903135" @default.
- W1977915772 hasPublicationYear "1993" @default.
- W1977915772 type Work @default.
- W1977915772 sameAs 1977915772 @default.
- W1977915772 citedByCount "11" @default.
- W1977915772 countsByYear W19779157722012 @default.
- W1977915772 countsByYear W19779157722015 @default.
- W1977915772 countsByYear W19779157722016 @default.
- W1977915772 countsByYear W19779157722018 @default.
- W1977915772 countsByYear W19779157722023 @default.
- W1977915772 crossrefType "journal-article" @default.
- W1977915772 hasAuthorship W1977915772A5030793401 @default.
- W1977915772 hasAuthorship W1977915772A5040012220 @default.
- W1977915772 hasAuthorship W1977915772A5061118106 @default.
- W1977915772 hasAuthorship W1977915772A5081813581 @default.
- W1977915772 hasConcept C126322002 @default.
- W1977915772 hasConcept C165901193 @default.
- W1977915772 hasConcept C199360897 @default.
- W1977915772 hasConcept C203014093 @default.
- W1977915772 hasConcept C2776908094 @default.
- W1977915772 hasConcept C2777411658 @default.
- W1977915772 hasConcept C2777499811 @default.
- W1977915772 hasConcept C2777629521 @default.
- W1977915772 hasConcept C2779359454 @default.
- W1977915772 hasConcept C3454156 @default.
- W1977915772 hasConcept C41008148 @default.
- W1977915772 hasConcept C42219234 @default.
- W1977915772 hasConcept C42972112 @default.
- W1977915772 hasConcept C534529494 @default.
- W1977915772 hasConcept C71924100 @default.
- W1977915772 hasConcept C90924648 @default.
- W1977915772 hasConceptScore W1977915772C126322002 @default.
- W1977915772 hasConceptScore W1977915772C165901193 @default.
- W1977915772 hasConceptScore W1977915772C199360897 @default.
- W1977915772 hasConceptScore W1977915772C203014093 @default.
- W1977915772 hasConceptScore W1977915772C2776908094 @default.
- W1977915772 hasConceptScore W1977915772C2777411658 @default.
- W1977915772 hasConceptScore W1977915772C2777499811 @default.
- W1977915772 hasConceptScore W1977915772C2777629521 @default.
- W1977915772 hasConceptScore W1977915772C2779359454 @default.
- W1977915772 hasConceptScore W1977915772C3454156 @default.
- W1977915772 hasConceptScore W1977915772C41008148 @default.
- W1977915772 hasConceptScore W1977915772C42219234 @default.
- W1977915772 hasConceptScore W1977915772C42972112 @default.
- W1977915772 hasConceptScore W1977915772C534529494 @default.
- W1977915772 hasConceptScore W1977915772C71924100 @default.
- W1977915772 hasConceptScore W1977915772C90924648 @default.
- W1977915772 hasIssue "1-2" @default.
- W1977915772 hasLocation W19779157721 @default.
- W1977915772 hasLocation W19779157722 @default.
- W1977915772 hasOpenAccess W1977915772 @default.
- W1977915772 hasPrimaryLocation W19779157721 @default.
- W1977915772 hasRelatedWork W177093907 @default.
- W1977915772 hasRelatedWork W1964870042 @default.
- W1977915772 hasRelatedWork W2137791886 @default.
- W1977915772 hasRelatedWork W2167582113 @default.
- W1977915772 hasRelatedWork W2302105412 @default.
- W1977915772 hasRelatedWork W2395697149 @default.
- W1977915772 hasRelatedWork W2410917046 @default.
- W1977915772 hasRelatedWork W2416223570 @default.
- W1977915772 hasRelatedWork W2463005588 @default.
- W1977915772 hasRelatedWork W2475076123 @default.
- W1977915772 hasVolume "55" @default.
- W1977915772 isParatext "false" @default.
- W1977915772 isRetracted "false" @default.
- W1977915772 magId "1977915772" @default.
- W1977915772 workType "article" @default.