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• W1977916714 endingPage "14366" @default.
• W1977916714 startingPage "14361" @default.
• W1977916714 abstract "Inhibition of DNA replication and physical DNA damage induce checkpoint responses that arrest cell cycle progression at two different stages. In Saccharomyces cerevisiae , the execution of both checkpoint responses requires the Mec1 and Rad53 proteins. This observation led to the suggestion that these checkpoint responses are mediated through a common signal transduction pathway. However, because the checkpoint-induced arrests occur at different cell cycle stages, the downstream effectors mediating these arrests are likely to be distinct. We have previously shown that the S. cerevisiae protein Pds1p is an anaphase inhibitor and is essential for cell cycle arrest in mitosis in the presence DNA damage. Herein we show that DNA damage, but not inhibition of DNA replication, induces the phosphorylation of Pds1p. Analyses of Pds1p phosphorylation in different checkpoint mutants reveal that in the presence of DNA damage, Pds1p is phosphorylated in a Mec1p- and Rad9p-dependent but Rad53p-independent manner. Our data place Pds1p and Rad53p on parallel branches of the DNA damage checkpoint pathway. We suggest that Pds1p is a downstream target of the DNA damage checkpoint pathway and that it is involved in implementing the DNA damage checkpoint arrest specifically in mitosis." @default.
• W1977916714 created "2016-06-24" @default.
• W1977916714 creator A5019022702 @default.
• W1977916714 creator A5040167004 @default.
• W1977916714 date "1997-12-23" @default.
• W1977916714 modified "2023-09-30" @default.
• W1977916714 title "The anaphase inhibitor of <i>Saccharomyces cerevisiae</i> Pds1p is a target of the DNA damage checkpoint pathway" @default.
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• W1977916714 doi "https://doi.org/10.1073/pnas.94.26.14361" @default.
• W1977916714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/24978" @default.
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• W1977916714 hasPublicationYear "1997" @default.
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