Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977919486> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1977919486 endingPage "e75760" @default.
- W1977919486 startingPage "e75760" @default.
- W1977919486 abstract "Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (CNS). For that, it is considered as an alternative target for psychotherapeutic drugs. On the cellular level, when Sig-1R is activated, it is known to play a role in neuroprotection and neurite elongation. These effects are suggested to be mediated by its ligand-operated molecular chaperone activity, and/or upregulation of various Ca(2+) signaling. In addition, recent studies show that Sig-1R activation induces neurite outgrowth via neurotrophin signaling. Here, we tested the hypothesis that Sig-1R activation promotes neurite elongation through activation of tropomyosin receptor kinase (Trk), a family of neurotrophin receptors. We found that 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE-084), a selective Sig-1R agonist, significantly promoted neurite outgrowth, and K252a, a Trk inhibitor, attenuated Sig-1R-mediated neurite elongation in cerebellar granule neurons (CGNs). Moreover, we revealed that Sig-1R interacts with TrkB, and PRE-084 treatment enhances phosphorylation of Y515, but not Y706. Thus, our results indicate that Sig-1R activation promotes neurite outgrowth in CGNs through Y515 phosphorylation of TrkB." @default.
- W1977919486 created "2016-06-24" @default.
- W1977919486 creator A5009539807 @default.
- W1977919486 creator A5021881488 @default.
- W1977919486 creator A5029874100 @default.
- W1977919486 creator A5043263625 @default.
- W1977919486 creator A5076608744 @default.
- W1977919486 date "2013-10-08" @default.
- W1977919486 modified "2023-10-03" @default.
- W1977919486 title "Sigma-1 Receptor Enhances Neurite Elongation of Cerebellar Granule Neurons via TrkB Signaling" @default.
- W1977919486 cites W1967964064 @default.
- W1977919486 doi "https://doi.org/10.1371/journal.pone.0075760" @default.
- W1977919486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3793001" @default.
- W1977919486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24116072" @default.
- W1977919486 hasPublicationYear "2013" @default.
- W1977919486 type Work @default.
- W1977919486 sameAs 1977919486 @default.
- W1977919486 citedByCount "40" @default.
- W1977919486 countsByYear W19779194862014 @default.
- W1977919486 countsByYear W19779194862015 @default.
- W1977919486 countsByYear W19779194862016 @default.
- W1977919486 countsByYear W19779194862017 @default.
- W1977919486 countsByYear W19779194862018 @default.
- W1977919486 countsByYear W19779194862019 @default.
- W1977919486 countsByYear W19779194862020 @default.
- W1977919486 countsByYear W19779194862021 @default.
- W1977919486 countsByYear W19779194862022 @default.
- W1977919486 countsByYear W19779194862023 @default.
- W1977919486 crossrefType "journal-article" @default.
- W1977919486 hasAuthorship W1977919486A5009539807 @default.
- W1977919486 hasAuthorship W1977919486A5021881488 @default.
- W1977919486 hasAuthorship W1977919486A5029874100 @default.
- W1977919486 hasAuthorship W1977919486A5043263625 @default.
- W1977919486 hasAuthorship W1977919486A5076608744 @default.
- W1977919486 hasBestOaLocation W19779194861 @default.
- W1977919486 hasConcept C113246987 @default.
- W1977919486 hasConcept C11960822 @default.
- W1977919486 hasConcept C134139212 @default.
- W1977919486 hasConcept C158617107 @default.
- W1977919486 hasConcept C160539049 @default.
- W1977919486 hasConcept C169760540 @default.
- W1977919486 hasConcept C170493617 @default.
- W1977919486 hasConcept C185592680 @default.
- W1977919486 hasConcept C202751555 @default.
- W1977919486 hasConcept C25498285 @default.
- W1977919486 hasConcept C2778938600 @default.
- W1977919486 hasConcept C55493867 @default.
- W1977919486 hasConcept C56703729 @default.
- W1977919486 hasConcept C62478195 @default.
- W1977919486 hasConcept C86803240 @default.
- W1977919486 hasConcept C92020748 @default.
- W1977919486 hasConcept C95444343 @default.
- W1977919486 hasConcept C97124661 @default.
- W1977919486 hasConceptScore W1977919486C113246987 @default.
- W1977919486 hasConceptScore W1977919486C11960822 @default.
- W1977919486 hasConceptScore W1977919486C134139212 @default.
- W1977919486 hasConceptScore W1977919486C158617107 @default.
- W1977919486 hasConceptScore W1977919486C160539049 @default.
- W1977919486 hasConceptScore W1977919486C169760540 @default.
- W1977919486 hasConceptScore W1977919486C170493617 @default.
- W1977919486 hasConceptScore W1977919486C185592680 @default.
- W1977919486 hasConceptScore W1977919486C202751555 @default.
- W1977919486 hasConceptScore W1977919486C25498285 @default.
- W1977919486 hasConceptScore W1977919486C2778938600 @default.
- W1977919486 hasConceptScore W1977919486C55493867 @default.
- W1977919486 hasConceptScore W1977919486C56703729 @default.
- W1977919486 hasConceptScore W1977919486C62478195 @default.
- W1977919486 hasConceptScore W1977919486C86803240 @default.
- W1977919486 hasConceptScore W1977919486C92020748 @default.
- W1977919486 hasConceptScore W1977919486C95444343 @default.
- W1977919486 hasConceptScore W1977919486C97124661 @default.
- W1977919486 hasIssue "10" @default.
- W1977919486 hasLocation W19779194861 @default.
- W1977919486 hasLocation W19779194862 @default.
- W1977919486 hasLocation W19779194863 @default.
- W1977919486 hasLocation W19779194864 @default.
- W1977919486 hasOpenAccess W1977919486 @default.
- W1977919486 hasPrimaryLocation W19779194861 @default.
- W1977919486 hasRelatedWork W2041041031 @default.
- W1977919486 hasRelatedWork W2048819791 @default.
- W1977919486 hasRelatedWork W2055350640 @default.
- W1977919486 hasRelatedWork W2076152511 @default.
- W1977919486 hasRelatedWork W2087696642 @default.
- W1977919486 hasRelatedWork W2103580807 @default.
- W1977919486 hasRelatedWork W2115896565 @default.
- W1977919486 hasRelatedWork W2118813298 @default.
- W1977919486 hasRelatedWork W3080879345 @default.
- W1977919486 hasRelatedWork W3198499435 @default.
- W1977919486 hasVolume "8" @default.
- W1977919486 isParatext "false" @default.
- W1977919486 isRetracted "false" @default.
- W1977919486 magId "1977919486" @default.
- W1977919486 workType "article" @default.