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- W1977926340 abstract "Triglyceride lipase (hydrolase) activity was determined in particulate (17 000 g and 100 000 g pellets) and soluble (100 000 g supernatant) subcellular fractions from rat epididymal fat pad homogenates. Particulate fractions exhibited both an acid (pH 4.5 to 5) and an alkaline (pH 8) pH optimum; in contrast, the soluble fraction was characterized as having a single pH optimum of 7.5. The addition of chloroquine to the triglyceride lipase assay resulted in an inhibition of acid lipase activity (half maximal inhibition at 20 to 25 mm chloroquine) whereas lipase activity measured at pH 7.5 was first stimulated by low concentrations of chloroquine (2 to 10 mm) and then inhibited with higher concentrations. The addition of chloroquine (10 μm or 50 μm) to Krebs-Henseleit bicarbonate buffer resulted in negative inotropic and chronotropic effects in isolated perfused rat hearts. Perfusion of rat hearts or preincubation of epididymal fat pads with Krebs-Henseleit bicarbonate buffer containing 10 μm or 50 μm chloroquine for 30 min did not decrease basal or epinephrine-stimulated rates of lipolysis as determined by measurements of glycerol release. Similarly, pretreatment of rats with chloroquine 2 h prior to killing had no effect on basal or epinephrine-stimulated rates of lipolysis in perfused hearts or in epididymal fat pads. Since chloroquine is a lysosomotropic agent, it is concluded that the lysosomal acid triglyceride lipase is unlikely to be involved in determining basal or hormone-stimulated rates of lipolysis." @default.
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- W1977926340 date "1980-10-01" @default.
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- W1977926340 title "Effect of chloroquine on rates of lipolysis in the isolated perfused rat heart and in rat epididymal fat pads" @default.
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- W1977926340 doi "https://doi.org/10.1016/0022-2828(80)90026-7" @default.
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