FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977928082> ?p ?o ?g. }

• W1977928082 endingPage "11" @default.
• W1977928082 startingPage "1" @default.
• W1977928082 abstract "Dipeptidyl peptidase IV (DP IV)-related proteases and aminopeptidase N (APN) are drug targets in various diseases. Here we investigated for the first time the effects of DP-IV-related protease inhibitors and APN inhibitors on chronic inflammatory lung diseases. A murine model of silica (SiO2)-induced lung fibrosis and in vitro cultures of human lung epithelial cells and monocytes have been used and the influence of silica-treatment and inhibitors on inflammation and fibrosis has been measured. We found increased inflammation and secretion of the chemokines IL-6, MCP-1 and MIP-α 2 weeks after SiO2 application, and increased lung fibrosis after 3 months. Treatment with the APN inhibitor actinonin reduced chemokine secretion in the lung and bronchoalveolar lavage fluid, and in cell culture, and decreased the level of fibrosis after 3 months. Treatment with inhibitors of DP-IV-related proteases, or a combination of DP IV inhibitors and APN inhibitors, had no significant effect. We found no obvious side effects of long-term treatment with inhibitors of APN and DP IV. Overall, our findings show that actinonin, an inhibitor of aminopeptidase N, might modulate chemokine secretion in the lung and thus attenuate the development of lung fibrosis. Additional targeting of DP-IV-related proteases had no significant effect on these processes." @default.
• W1977928082 created "2016-06-24" @default.
• W1977928082 creator A5016822084 @default.
• W1977928082 creator A5024583139 @default.
• W1977928082 creator A5029715865 @default.
• W1977928082 creator A5053203013 @default.
• W1977928082 creator A5084519339 @default.
• W1977928082 creator A5084902457 @default.
• W1977928082 creator A5090409191 @default.
• W1977928082 date "2009-01-01" @default.
• W1977928082 modified "2023-10-13" @default.
• W1977928082 title "Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases" @default.
• W1977928082 cites W142399070 @default.
• W1977928082 cites W1515961721 @default.
• W1977928082 cites W1554419393 @default.
• W1977928082 cites W1570028076 @default.
• W1977928082 cites W1578545218 @default.
• W1977928082 cites W1786137152 @default.
• W1977928082 cites W1880224603 @default.
• W1977928082 cites W1937255969 @default.
• W1977928082 cites W1947376355 @default.
• W1977928082 cites W1965834132 @default.
• W1977928082 cites W1966418185 @default.
• W1977928082 cites W1966535906 @default.
• W1977928082 cites W1971018479 @default.
• W1977928082 cites W1973817001 @default.
• W1977928082 cites W1987031807 @default.
• W1977928082 cites W1988886961 @default.
• W1977928082 cites W1989743958 @default.
• W1977928082 cites W1999332484 @default.
• W1977928082 cites W2001534341 @default.
• W1977928082 cites W2003195877 @default.
• W1977928082 cites W2012194350 @default.
• W1977928082 cites W2014442966 @default.
• W1977928082 cites W2018410634 @default.
• W1977928082 cites W2020603363 @default.
• W1977928082 cites W2026736952 @default.
• W1977928082 cites W2028849170 @default.
• W1977928082 cites W2029094565 @default.
• W1977928082 cites W2030005765 @default.
• W1977928082 cites W2031468509 @default.
• W1977928082 cites W2033980270 @default.
• W1977928082 cites W2042780785 @default.
• W1977928082 cites W2047110515 @default.
• W1977928082 cites W2056019934 @default.
• W1977928082 cites W2056837338 @default.
• W1977928082 cites W2057174655 @default.
• W1977928082 cites W2071601558 @default.
• W1977928082 cites W2080249555 @default.
• W1977928082 cites W2083762787 @default.
• W1977928082 cites W2089062394 @default.
• W1977928082 cites W2089073177 @default.
• W1977928082 cites W2098511235 @default.
• W1977928082 cites W2111383848 @default.
• W1977928082 cites W2118314014 @default.
• W1977928082 cites W2152587418 @default.
• W1977928082 cites W2165056630 @default.
• W1977928082 cites W2215360874 @default.
• W1977928082 cites W2262606490 @default.
• W1977928082 cites W2338349263 @default.
• W1977928082 cites W2626588662 @default.
• W1977928082 cites W30357743 @default.
• W1977928082 cites W331732724 @default.
• W1977928082 cites W97880664 @default.
• W1977928082 cites W70032878 @default.
• W1977928082 doi "https://doi.org/10.1016/j.lfs.2008.10.001" @default.
• W1977928082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18973761" @default.
• W1977928082 hasPublicationYear "2009" @default.
• W1977928082 type Work @default.
• W1977928082 sameAs 1977928082 @default.
• W1977928082 citedByCount "16" @default.
• W1977928082 countsByYear W19779280822012 @default.
• W1977928082 countsByYear W19779280822013 @default.
• W1977928082 countsByYear W19779280822014 @default.
• W1977928082 countsByYear W19779280822015 @default.
• W1977928082 countsByYear W19779280822018 @default.
• W1977928082 countsByYear W19779280822019 @default.
• W1977928082 countsByYear W19779280822020 @default.
• W1977928082 countsByYear W19779280822021 @default.
• W1977928082 crossrefType "journal-article" @default.
• W1977928082 hasAuthorship W1977928082A5016822084 @default.
• W1977928082 hasAuthorship W1977928082A5024583139 @default.
• W1977928082 hasAuthorship W1977928082A5029715865 @default.
• W1977928082 hasAuthorship W1977928082A5053203013 @default.
• W1977928082 hasAuthorship W1977928082A5084519339 @default.
• W1977928082 hasAuthorship W1977928082A5084902457 @default.
• W1977928082 hasAuthorship W1977928082A5090409191 @default.
• W1977928082 hasConcept C126322002 @default.
• W1977928082 hasConcept C13373296 @default.
• W1977928082 hasConcept C134018914 @default.
• W1977928082 hasConcept C156490143 @default.
• W1977928082 hasConcept C181199279 @default.
• W1977928082 hasConcept C182220744 @default.
• W1977928082 hasConcept C185592680 @default.
• W1977928082 hasConcept C203014093 @default.
• W1977928082 hasConcept C2776580952 @default.
• W1977928082 hasConcept C2776914184 @default.
• W1977928082 hasConcept C2777180221 @default.

• next