FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977956790> ?p ?o ?g. }

• W1977956790 endingPage "859" @default.
• W1977956790 startingPage "854" @default.
• W1977956790 abstract "Hypothesis: Leukocyte recruitment to the cochlea can be induced by tumor necrosis factor α (TNF-α) at concentrations that are not cytotoxic to sensory cells in the organ of Corti. Background: Leukocytes participating in inflammation enter the inner ear via the spiral modiolar vein and its tributaries. Many of the infiltrated leukocytes express TNF-α 3 hours after cochlear antigen challenge of systemically antigen-sensitized animals. Competitive inhibition of TNF-α receptors reduces inflammation and hearing loss in experimentally induced labyrinthitis in guinea pigs and mice. However, TNF-α is also potentially cytotoxic, acting through the external apoptotic pathway and TNF-α transmembrane, cell surface receptors. It may therefore also participate in the sensory cell degeneration resulting from inflammation. Methods: To test for recruitment potential, TNF-α or phosphate-buffered saline was infused into the guinea pig inner ear for 2 to 4 days through a cochleostomy using an osmotic pump (0.2 or 2.0 μg/mL; 1 μL/h) or a bolus injection (50 μg/mL; 10 μL). Auditory evoked brainstem response thresholds were measured before and after challenge, and cochleas were evaluated for the presence of leukocytes. To test for toxicity, organ of Corti explants were subjected to 3 concentrations of TNF-α (0.1, 10, and 1,000 ng/mL) for 96 hours, and the number of hair cell places was counted. Results: Tumor necrosis factor α infused into the guinea pig cochlear scala tympani resulted in infiltration of leukocytes around the venules and within scala tympani. There was no associated hearing loss as measured with a click stimulus. Tumor necrosis factor α applied directly to organ of Corti explants caused minimal hair cell death at concentrations used in the in vivo experiments. At higher concentrations, there was 15 to 20% loss of cells. Conclusion: Tumor necrosis factor α is sufficient to recruit inflammatory cells to the cochlea but is not likely to be directly responsible for the hearing loss that follows immune-mediated labyrinthitis." @default.
• W1977956790 created "2016-06-24" @default.
• W1977956790 creator A5057292712 @default.
• W1977956790 creator A5075072731 @default.
• W1977956790 creator A5075081952 @default.
• W1977956790 date "2008-09-01" @default.
• W1977956790 modified "2023-09-30" @default.
• W1977956790 title "Tumor Necrosis Factor α Can Induce Recruitment of Inflammatory Cells to the Cochlea" @default.
• W1977956790 cites W1508259443 @default.
• W1977956790 cites W1661430296 @default.
• W1977956790 cites W1951903104 @default.
• W1977956790 cites W1970582469 @default.
• W1977956790 cites W1972679022 @default.
• W1977956790 cites W1972732808 @default.
• W1977956790 cites W1985912987 @default.
• W1977956790 cites W1991106174 @default.
• W1977956790 cites W1993723572 @default.
• W1977956790 cites W1999902482 @default.
• W1977956790 cites W2005154068 @default.
• W1977956790 cites W2013396960 @default.
• W1977956790 cites W2033281822 @default.
• W1977956790 cites W2039807538 @default.
• W1977956790 cites W2048579894 @default.
• W1977956790 cites W2053325646 @default.
• W1977956790 cites W2069141048 @default.
• W1977956790 cites W2072380594 @default.
• W1977956790 cites W2087954943 @default.
• W1977956790 cites W2092866020 @default.
• W1977956790 cites W2094211456 @default.
• W1977956790 cites W2141512146 @default.
• W1977956790 cites W2292514562 @default.
• W1977956790 cites W2322070679 @default.
• W1977956790 cites W2413170799 @default.
• W1977956790 doi "https://doi.org/10.1097/mao.0b013e31818256a9" @default.
• W1977956790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18636025" @default.
• W1977956790 hasPublicationYear "2008" @default.
• W1977956790 type Work @default.
• W1977956790 sameAs 1977956790 @default.
• W1977956790 citedByCount "76" @default.
• W1977956790 countsByYear W19779567902012 @default.
• W1977956790 countsByYear W19779567902013 @default.
• W1977956790 countsByYear W19779567902014 @default.
• W1977956790 countsByYear W19779567902015 @default.
• W1977956790 countsByYear W19779567902016 @default.
• W1977956790 countsByYear W19779567902017 @default.
• W1977956790 countsByYear W19779567902018 @default.
• W1977956790 countsByYear W19779567902019 @default.
• W1977956790 countsByYear W19779567902020 @default.
• W1977956790 countsByYear W19779567902021 @default.
• W1977956790 countsByYear W19779567902022 @default.
• W1977956790 countsByYear W19779567902023 @default.
• W1977956790 crossrefType "journal-article" @default.
• W1977956790 hasAuthorship W1977956790A5057292712 @default.
• W1977956790 hasAuthorship W1977956790A5075072731 @default.
• W1977956790 hasAuthorship W1977956790A5075081952 @default.
• W1977956790 hasConcept C105702510 @default.
• W1977956790 hasConcept C142724271 @default.
• W1977956790 hasConcept C17991360 @default.
• W1977956790 hasConcept C203014093 @default.
• W1977956790 hasConcept C2776914184 @default.
• W1977956790 hasConcept C2778317342 @default.
• W1977956790 hasConcept C2778500370 @default.
• W1977956790 hasConcept C2779134260 @default.
• W1977956790 hasConcept C2780130748 @default.
• W1977956790 hasConcept C2780659331 @default.
• W1977956790 hasConcept C2780865074 @default.
• W1977956790 hasConcept C2781098194 @default.
• W1977956790 hasConcept C503630168 @default.
• W1977956790 hasConcept C71924100 @default.
• W1977956790 hasConceptScore W1977956790C105702510 @default.
• W1977956790 hasConceptScore W1977956790C142724271 @default.
• W1977956790 hasConceptScore W1977956790C17991360 @default.
• W1977956790 hasConceptScore W1977956790C203014093 @default.
• W1977956790 hasConceptScore W1977956790C2776914184 @default.
• W1977956790 hasConceptScore W1977956790C2778317342 @default.
• W1977956790 hasConceptScore W1977956790C2778500370 @default.
• W1977956790 hasConceptScore W1977956790C2779134260 @default.
• W1977956790 hasConceptScore W1977956790C2780130748 @default.
• W1977956790 hasConceptScore W1977956790C2780659331 @default.
• W1977956790 hasConceptScore W1977956790C2780865074 @default.
• W1977956790 hasConceptScore W1977956790C2781098194 @default.
• W1977956790 hasConceptScore W1977956790C503630168 @default.
• W1977956790 hasConceptScore W1977956790C71924100 @default.
• W1977956790 hasIssue "6" @default.
• W1977956790 hasLocation W19779567901 @default.
• W1977956790 hasLocation W19779567902 @default.
• W1977956790 hasOpenAccess W1977956790 @default.
• W1977956790 hasPrimaryLocation W19779567901 @default.
• W1977956790 hasRelatedWork W153012555 @default.
• W1977956790 hasRelatedWork W1977956790 @default.
• W1977956790 hasRelatedWork W2055037453 @default.
• W1977956790 hasRelatedWork W2059022549 @default.
• W1977956790 hasRelatedWork W2062676194 @default.
• W1977956790 hasRelatedWork W2083904336 @default.
• W1977956790 hasRelatedWork W2087543670 @default.
• W1977956790 hasRelatedWork W2093067536 @default.
• W1977956790 hasRelatedWork W2369148740 @default.
• W1977956790 hasRelatedWork W2597448676 @default.

• next