FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977960047> ?p ?o ?g. }

• W1977960047 endingPage "1279" @default.
• W1977960047 startingPage "1274" @default.
• W1977960047 abstract "Background —Homozygosity for a relatively common Cys282Tyr mutation of the human hemochromatosis-associated ( HFE ) gene was recently found to account for most cases of hereditary hemochromatosis. Because excess iron has been postulated to enhance risk of vascular disease, we studied whether occurrence of this mutation was associated with increased risk of first acute myocardial infarction in healthy middle-aged men in a prospective cohort study. Methods and Results —Study subjects were the 1150 participants in the population-based Kuopio Ischemic Heart Disease Risk Factor Study (KIHD), aged 42, 48, 54, or 60 years at baseline, who had no coronary heart disease at baseline and for whom a DNA sample was available. Information about myocardial infarctions was collected prospectively by use of FINMONICA (FINnish MONItoring of trends and determinants in CArdiovascular disease study) and hospital data. Events were classified by MONICA (MONItoring of trends and determinants in CArdiovascular disease study) diagnostic criteria. The HFE Cys282Tyr mutation was assayed by a solid-phase minisequencing technique. One subject was homozygous and 76 individuals were heterozygous for the HFE Cys282Tyr mutation (6.7%). During a mean follow-up of 9 years, 8 (10.4%) of 77 carriers and 60 (5.6%) of 1073 noncarriers experienced an acute myocardial infarction. In a Cox proportional hazards model allowing for the other strongest risk factors, the carriers had a 2.3-fold (95% CI 1.1 to 4.8; P =0.03) risk of acute myocardial infarction compared with noncarriers. Conclusions —Male carriers of the common hemochromatosis gene mutation are at 2-fold risk for first acute myocardial infarction compared with noncarriers." @default.
• W1977960047 created "2016-06-24" @default.
• W1977960047 creator A5000869716 @default.
• W1977960047 creator A5012235648 @default.
• W1977960047 creator A5012697760 @default.
• W1977960047 creator A5028231498 @default.
• W1977960047 creator A5060791374 @default.
• W1977960047 creator A5074393825 @default.
• W1977960047 date "1999-09-21" @default.
• W1977960047 modified "2023-10-18" @default.
• W1977960047 title "Increased Risk of Acute Myocardial Infarction in Carriers of the Hemochromatosis Gene Cys282Tyr Mutation" @default.
• W1977960047 cites W1516636175 @default.
• W1977960047 cites W163177553 @default.
• W1977960047 cites W1976636114 @default.
• W1977960047 cites W1993899490 @default.
• W1977960047 cites W1995697203 @default.
• W1977960047 cites W2002605005 @default.
• W1977960047 cites W2021087098 @default.
• W1977960047 cites W2029753366 @default.
• W1977960047 cites W2038944724 @default.
• W1977960047 cites W2042443618 @default.
• W1977960047 cites W2045285912 @default.
• W1977960047 cites W2052060629 @default.
• W1977960047 cites W2068776552 @default.
• W1977960047 cites W2071152192 @default.
• W1977960047 cites W2080638597 @default.
• W1977960047 cites W2094430270 @default.
• W1977960047 cites W2139293212 @default.
• W1977960047 cites W2141937988 @default.
• W1977960047 cites W2143716524 @default.
• W1977960047 cites W2145306168 @default.
• W1977960047 cites W2158363469 @default.
• W1977960047 cites W2165322433 @default.
• W1977960047 cites W2308331182 @default.
• W1977960047 cites W2312530933 @default.
• W1977960047 cites W2314218964 @default.
• W1977960047 cites W2335705178 @default.
• W1977960047 cites W2341292512 @default.
• W1977960047 doi "https://doi.org/10.1161/01.cir.100.12.1274" @default.
• W1977960047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10491370" @default.
• W1977960047 hasPublicationYear "1999" @default.
• W1977960047 type Work @default.
• W1977960047 sameAs 1977960047 @default.
• W1977960047 citedByCount "216" @default.
• W1977960047 countsByYear W19779600472012 @default.
• W1977960047 countsByYear W19779600472013 @default.
• W1977960047 countsByYear W19779600472014 @default.
• W1977960047 countsByYear W19779600472015 @default.
• W1977960047 countsByYear W19779600472016 @default.
• W1977960047 countsByYear W19779600472017 @default.
• W1977960047 countsByYear W19779600472019 @default.
• W1977960047 countsByYear W19779600472020 @default.
• W1977960047 countsByYear W19779600472021 @default.
• W1977960047 countsByYear W19779600472022 @default.
• W1977960047 countsByYear W19779600472023 @default.
• W1977960047 crossrefType "journal-article" @default.
• W1977960047 hasAuthorship W1977960047A5000869716 @default.
• W1977960047 hasAuthorship W1977960047A5012235648 @default.
• W1977960047 hasAuthorship W1977960047A5012697760 @default.
• W1977960047 hasAuthorship W1977960047A5028231498 @default.
• W1977960047 hasAuthorship W1977960047A5060791374 @default.
• W1977960047 hasAuthorship W1977960047A5074393825 @default.
• W1977960047 hasBestOaLocation W19779600471 @default.
• W1977960047 hasConcept C104317684 @default.
• W1977960047 hasConcept C126322002 @default.
• W1977960047 hasConcept C164705383 @default.
• W1977960047 hasConcept C188816634 @default.
• W1977960047 hasConcept C2776590208 @default.
• W1977960047 hasConcept C2779134260 @default.
• W1977960047 hasConcept C2908647359 @default.
• W1977960047 hasConcept C2994225774 @default.
• W1977960047 hasConcept C3018783601 @default.
• W1977960047 hasConcept C500558357 @default.
• W1977960047 hasConcept C501734568 @default.
• W1977960047 hasConcept C50440223 @default.
• W1977960047 hasConcept C54355233 @default.
• W1977960047 hasConcept C71924100 @default.
• W1977960047 hasConcept C86803240 @default.
• W1977960047 hasConcept C99454951 @default.
• W1977960047 hasConceptScore W1977960047C104317684 @default.
• W1977960047 hasConceptScore W1977960047C126322002 @default.
• W1977960047 hasConceptScore W1977960047C164705383 @default.
• W1977960047 hasConceptScore W1977960047C188816634 @default.
• W1977960047 hasConceptScore W1977960047C2776590208 @default.
• W1977960047 hasConceptScore W1977960047C2779134260 @default.
• W1977960047 hasConceptScore W1977960047C2908647359 @default.
• W1977960047 hasConceptScore W1977960047C2994225774 @default.
• W1977960047 hasConceptScore W1977960047C3018783601 @default.
• W1977960047 hasConceptScore W1977960047C500558357 @default.
• W1977960047 hasConceptScore W1977960047C501734568 @default.
• W1977960047 hasConceptScore W1977960047C50440223 @default.
• W1977960047 hasConceptScore W1977960047C54355233 @default.
• W1977960047 hasConceptScore W1977960047C71924100 @default.
• W1977960047 hasConceptScore W1977960047C86803240 @default.
• W1977960047 hasConceptScore W1977960047C99454951 @default.
• W1977960047 hasIssue "12" @default.
• W1977960047 hasLocation W19779600471 @default.
• W1977960047 hasLocation W19779600472 @default.

• next