Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977960080> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1977960080 endingPage "237" @default.
- W1977960080 startingPage "233" @default.
- W1977960080 abstract "Bromocriptine, a dopamine agonist that blocks the secretion of MSH, inhibits melanogenesis in the hair follicular melanocytes of pubertal C3H-HeAvy mice. However, since this effect cannot be explained by a reduction in circulating alpha-MSH, we have examined the possibility that dopaminergic mechanisms may have a direct inhibitory effect on these melanocytes. Bromocriptine decreased tyrosinase activity in skin explants from 30- to 35-day-old mice that were growing dark hair. This decrease in tyrosinase activity was blocked by dopamine receptor antagonists, haloperidol or spiperone. The specific D2 agonist LY 171555 also inhibited tyrosinase activity in the skin explants in a dose-related manner and the effect was blocked by sulpiride, a D2-receptor antagonist. Neither bromocriptine nor LY 171555 had any effect on tyrosinase activity in skin explants taken from adult mice that were growing yellow hair. The D1-receptor agonist SKF 38393 had no effect on tyrosinase activity in skin explants from either group of mice. The present results support the idea that dopamine D2-receptor agonists have a direct inhibitory effect upon tyrosinase activity of hair follicular melanocytes of the C3H-HeAvy mouse. However, this effect was confined to periods of dark hair growth when the melanocytes produce eumelanin. The D2 agonists were ineffective in reducing tyrosinase activity during adult life when the melanocytes produce predominantly phaeomelanin. This suggests that different control mechanisms may operate in the hair follicular melanocytes during periods of eumelanin and phaeomelanin synthesis." @default.
- W1977960080 created "2016-06-24" @default.
- W1977960080 creator A5037289377 @default.
- W1977960080 creator A5072698359 @default.
- W1977960080 date "1986-11-01" @default.
- W1977960080 modified "2023-10-02" @default.
- W1977960080 title "Dopaminergic inhibition of tyrosinase activity in hair follicular melanocytes of the mouse" @default.
- W1977960080 doi "https://doi.org/10.1677/joe.0.1110233" @default.
- W1977960080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3098885" @default.
- W1977960080 hasPublicationYear "1986" @default.
- W1977960080 type Work @default.
- W1977960080 sameAs 1977960080 @default.
- W1977960080 citedByCount "20" @default.
- W1977960080 countsByYear W19779600802012 @default.
- W1977960080 countsByYear W19779600802015 @default.
- W1977960080 countsByYear W19779600802016 @default.
- W1977960080 countsByYear W19779600802017 @default.
- W1977960080 countsByYear W19779600802021 @default.
- W1977960080 countsByYear W19779600802022 @default.
- W1977960080 crossrefType "journal-article" @default.
- W1977960080 hasAuthorship W1977960080A5037289377 @default.
- W1977960080 hasAuthorship W1977960080A5072698359 @default.
- W1977960080 hasConcept C107538193 @default.
- W1977960080 hasConcept C120069818 @default.
- W1977960080 hasConcept C126322002 @default.
- W1977960080 hasConcept C134018914 @default.
- W1977960080 hasConcept C137183658 @default.
- W1977960080 hasConcept C170493617 @default.
- W1977960080 hasConcept C181199279 @default.
- W1977960080 hasConcept C185592680 @default.
- W1977960080 hasConcept C2776856834 @default.
- W1977960080 hasConcept C2778258207 @default.
- W1977960080 hasConcept C2778938600 @default.
- W1977960080 hasConcept C2779064019 @default.
- W1977960080 hasConcept C44208683 @default.
- W1977960080 hasConcept C513476851 @default.
- W1977960080 hasConcept C55493867 @default.
- W1977960080 hasConcept C71315377 @default.
- W1977960080 hasConcept C71924100 @default.
- W1977960080 hasConcept C86803240 @default.
- W1977960080 hasConcept C87554066 @default.
- W1977960080 hasConceptScore W1977960080C107538193 @default.
- W1977960080 hasConceptScore W1977960080C120069818 @default.
- W1977960080 hasConceptScore W1977960080C126322002 @default.
- W1977960080 hasConceptScore W1977960080C134018914 @default.
- W1977960080 hasConceptScore W1977960080C137183658 @default.
- W1977960080 hasConceptScore W1977960080C170493617 @default.
- W1977960080 hasConceptScore W1977960080C181199279 @default.
- W1977960080 hasConceptScore W1977960080C185592680 @default.
- W1977960080 hasConceptScore W1977960080C2776856834 @default.
- W1977960080 hasConceptScore W1977960080C2778258207 @default.
- W1977960080 hasConceptScore W1977960080C2778938600 @default.
- W1977960080 hasConceptScore W1977960080C2779064019 @default.
- W1977960080 hasConceptScore W1977960080C44208683 @default.
- W1977960080 hasConceptScore W1977960080C513476851 @default.
- W1977960080 hasConceptScore W1977960080C55493867 @default.
- W1977960080 hasConceptScore W1977960080C71315377 @default.
- W1977960080 hasConceptScore W1977960080C71924100 @default.
- W1977960080 hasConceptScore W1977960080C86803240 @default.
- W1977960080 hasConceptScore W1977960080C87554066 @default.
- W1977960080 hasIssue "2" @default.
- W1977960080 hasLocation W19779600801 @default.
- W1977960080 hasLocation W19779600802 @default.
- W1977960080 hasOpenAccess W1977960080 @default.
- W1977960080 hasPrimaryLocation W19779600801 @default.
- W1977960080 hasRelatedWork W168495738 @default.
- W1977960080 hasRelatedWork W1966176551 @default.
- W1977960080 hasRelatedWork W1977960080 @default.
- W1977960080 hasRelatedWork W2006136814 @default.
- W1977960080 hasRelatedWork W2010071752 @default.
- W1977960080 hasRelatedWork W2019937176 @default.
- W1977960080 hasRelatedWork W2132924839 @default.
- W1977960080 hasRelatedWork W2753848907 @default.
- W1977960080 hasRelatedWork W4224302975 @default.
- W1977960080 hasRelatedWork W4242416025 @default.
- W1977960080 hasVolume "111" @default.
- W1977960080 isParatext "false" @default.
- W1977960080 isRetracted "false" @default.
- W1977960080 magId "1977960080" @default.
- W1977960080 workType "article" @default.