FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977962009> ?p ?o ?g. }

• W1977962009 endingPage "985" @default.
• W1977962009 startingPage "976" @default.
• W1977962009 abstract "Chondrocyte death in articular cartilage wound edges and the subsequent lack of matrix-producing cells in the interface area are considered to be a major cause of impaired cartilage wound healing and poor integrative cartilage repair. This study was undertaken to investigate whether enzymatic matrix digestion can be used to stimulate integrative cartilage repair via a mechanism of local increase in the amount of vital chondrocytes in cartilage wound edges.Full-thickness bovine articular cartilage samples were cultured in vitro for 14 days in standard medium. Samples were either left untreated or treated for 48 hours with 0.3% hyaluronidase or 30 units/ml highly purified collagenase VII. Nuclear and cytoplasmic changes were analyzed to determine cell viability, and the number of vital chondrocytes in wound edges was determined. Subsequently, we investigated whether increased chondrocyte density in the lesion edges resulted in better wound healing. Finally, full-thickness human tibial plateau cartilage explants were tested with similar enzyme treatment protocols to determine the clinical value of our results.In bovine explants a rapid onset of chondrocyte death was observed in wound edges in all treatment groups. This led to low chondrocyte density in a band of 0-150 microm from the lesion edges in untreated and hyaluronidase-treated explants. Treatment with 30 units/ml collagenase resulted in a significant increase in chondrocyte density in this area. The integration experiments demonstrated improved integration of the lesion edges after treatment with collagenase. In human articular cartilage an increase in chondrocyte density at the lesion edges could also be achieved, but only when proteoglycans were depleted from the wound edges prior to collagenase treatment.Treatment with highly purified collagenase improves integrative cartilage repair, possibly by increasing the cell density at cartilage wound edges." @default.
• W1977962009 created "2016-06-24" @default.
• W1977962009 creator A5020643810 @default.
• W1977962009 creator A5035697100 @default.
• W1977962009 creator A5057944152 @default.
• W1977962009 creator A5060475981 @default.
• W1977962009 creator A5085468214 @default.
• W1977962009 date "2002-04-01" @default.
• W1977962009 modified "2023-09-25" @default.
• W1977962009 title "Specific enzymatic treatment of bovine and human articular cartilage: Implications for integrative cartilage repair" @default.
• W1977962009 cites W1522229466 @default.
• W1977962009 cites W1805858026 @default.
• W1977962009 cites W1825470077 @default.
• W1977962009 cites W1993695467 @default.
• W1977962009 cites W2008750339 @default.
• W1977962009 cites W2017621537 @default.
• W1977962009 cites W2029898871 @default.
• W1977962009 cites W2031592383 @default.
• W1977962009 cites W2043893714 @default.
• W1977962009 cites W2044167629 @default.
• W1977962009 cites W2053271333 @default.
• W1977962009 cites W2057635936 @default.
• W1977962009 cites W2058786772 @default.
• W1977962009 cites W2078105563 @default.
• W1977962009 cites W2080847320 @default.
• W1977962009 cites W2084011763 @default.
• W1977962009 cites W2090120564 @default.
• W1977962009 cites W2097457307 @default.
• W1977962009 cites W2106128380 @default.
• W1977962009 cites W2112404859 @default.
• W1977962009 cites W2159542600 @default.
• W1977962009 cites W2281256922 @default.
• W1977962009 cites W2283732805 @default.
• W1977962009 cites W2400839407 @default.
• W1977962009 cites W2466454142 @default.
• W1977962009 cites W2983030030 @default.
• W1977962009 cites W4244156420 @default.
• W1977962009 cites W4375261546 @default.
• W1977962009 doi "https://doi.org/10.1002/art.10208" @default.
• W1977962009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11953975" @default.
• W1977962009 hasPublicationYear "2002" @default.
• W1977962009 type Work @default.
• W1977962009 sameAs 1977962009 @default.
• W1977962009 citedByCount "89" @default.
• W1977962009 countsByYear W19779620092012 @default.
• W1977962009 countsByYear W19779620092013 @default.
• W1977962009 countsByYear W19779620092014 @default.
• W1977962009 countsByYear W19779620092015 @default.
• W1977962009 countsByYear W19779620092016 @default.
• W1977962009 countsByYear W19779620092017 @default.
• W1977962009 countsByYear W19779620092018 @default.
• W1977962009 countsByYear W19779620092019 @default.
• W1977962009 countsByYear W19779620092020 @default.
• W1977962009 countsByYear W19779620092021 @default.
• W1977962009 countsByYear W19779620092022 @default.
• W1977962009 countsByYear W19779620092023 @default.
• W1977962009 crossrefType "journal-article" @default.
• W1977962009 hasAuthorship W1977962009A5020643810 @default.
• W1977962009 hasAuthorship W1977962009A5035697100 @default.
• W1977962009 hasAuthorship W1977962009A5057944152 @default.
• W1977962009 hasAuthorship W1977962009A5060475981 @default.
• W1977962009 hasAuthorship W1977962009A5085468214 @default.
• W1977962009 hasConcept C105702510 @default.
• W1977962009 hasConcept C106487976 @default.
• W1977962009 hasConcept C141071460 @default.
• W1977962009 hasConcept C142724271 @default.
• W1977962009 hasConcept C16685009 @default.
• W1977962009 hasConcept C181199279 @default.
• W1977962009 hasConcept C185592680 @default.
• W1977962009 hasConcept C189165786 @default.
• W1977962009 hasConcept C204787440 @default.
• W1977962009 hasConcept C2776164576 @default.
• W1977962009 hasConcept C2778394429 @default.
• W1977962009 hasConcept C2780269544 @default.
• W1977962009 hasConcept C2780375986 @default.
• W1977962009 hasConcept C2780550940 @default.
• W1977962009 hasConcept C2781156865 @default.
• W1977962009 hasConcept C2781403057 @default.
• W1977962009 hasConcept C43617362 @default.
• W1977962009 hasConcept C55493867 @default.
• W1977962009 hasConcept C71924100 @default.
• W1977962009 hasConcept C86803240 @default.
• W1977962009 hasConcept C95444343 @default.
• W1977962009 hasConceptScore W1977962009C105702510 @default.
• W1977962009 hasConceptScore W1977962009C106487976 @default.
• W1977962009 hasConceptScore W1977962009C141071460 @default.
• W1977962009 hasConceptScore W1977962009C142724271 @default.
• W1977962009 hasConceptScore W1977962009C16685009 @default.
• W1977962009 hasConceptScore W1977962009C181199279 @default.
• W1977962009 hasConceptScore W1977962009C185592680 @default.
• W1977962009 hasConceptScore W1977962009C189165786 @default.
• W1977962009 hasConceptScore W1977962009C204787440 @default.
• W1977962009 hasConceptScore W1977962009C2776164576 @default.
• W1977962009 hasConceptScore W1977962009C2778394429 @default.
• W1977962009 hasConceptScore W1977962009C2780269544 @default.
• W1977962009 hasConceptScore W1977962009C2780375986 @default.
• W1977962009 hasConceptScore W1977962009C2780550940 @default.
• W1977962009 hasConceptScore W1977962009C2781156865 @default.

• next