FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977976049> ?p ?o ?g. }

• W1977976049 endingPage "2516" @default.
• W1977976049 startingPage "2501" @default.
• W1977976049 abstract "We provide evidence that TWIK-related acid-sensitive potassium channel 1 (TASK1), a member of the family of two-pore domain potassium channels relevant for setting the resting membrane potential and balancing neuronal excitability that is expressed on T cells and neurons, is a key modulator of T cell immunity and neurodegeneration in autoimmune central nervous system inflammation. After induction of experimental autoimmune encephalomyelitis, an experimental model mimicking multiple sclerosis, TASK1−/− mice showed a significantly reduced clinical severity and markedly reduced axonal degeneration compared with wild-type controls. T cells from TASK1−/− mice displayed impaired T cell proliferation and cytokine production, while the immune repertoire is otherwise normal. In addition to these effects on systemic T cell responses, TASK1 exhibits an independent neuroprotective effect which was demonstrated using both a model of acutely prepared brain slices cocultured with activated T cells as well as in vitro cultivation experiments with isolated optic nerves. Anandamide, an endogenous cannabinoid and inhibitor of TASK channels, reduced outward currents and inhibited effector functions of T cells (IFN-γ production and proliferation); an effect completely abrogated in TASK1−/− mice. Accordingly, preventive blockade of TASK1 significantly ameliorated experimental autoimmune encephalomyelitis after immunization. Therapeutic application of anandamide significantly reduced disease severity and was capable of lowering progressive loss of brain parenchymal volume as assessed by magnetic resonance imaging. These data support the identification and characterization of TASK1 as potential molecular target for the therapy of inflammatory and degenerative central nervous system disorders." @default.
• W1977976049 created "2016-06-24" @default.
• W1977976049 creator A5005103364 @default.
• W1977976049 creator A5019876508 @default.
• W1977976049 creator A5034872348 @default.
• W1977976049 creator A5038373894 @default.
• W1977976049 creator A5040381414 @default.
• W1977976049 creator A5052707847 @default.
• W1977976049 creator A5068927429 @default.
• W1977976049 creator A5069194606 @default.
• W1977976049 creator A5071012492 @default.
• W1977976049 creator A5071976003 @default.
• W1977976049 creator A5084085802 @default.
• W1977976049 date "2009-07-01" @default.
• W1977976049 modified "2023-10-01" @default.
• W1977976049 title "TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system" @default.
• W1977976049 cites W1506884824 @default.
• W1977976049 cites W1862411043 @default.
• W1977976049 cites W1941376039 @default.
• W1977976049 cites W1964124586 @default.
• W1977976049 cites W1967209991 @default.
• W1977976049 cites W1971456679 @default.
• W1977976049 cites W1972647546 @default.
• W1977976049 cites W1974344330 @default.
• W1977976049 cites W1976365446 @default.
• W1977976049 cites W1981399050 @default.
• W1977976049 cites W1986173197 @default.
• W1977976049 cites W1989073099 @default.
• W1977976049 cites W1993637697 @default.
• W1977976049 cites W1993688922 @default.
• W1977976049 cites W1996892917 @default.
• W1977976049 cites W1997024092 @default.
• W1977976049 cites W2000485285 @default.
• W1977976049 cites W2004510097 @default.
• W1977976049 cites W2004536978 @default.
• W1977976049 cites W2007360114 @default.
• W1977976049 cites W2007578821 @default.
• W1977976049 cites W2008276507 @default.
• W1977976049 cites W2008479667 @default.
• W1977976049 cites W2009211845 @default.
• W1977976049 cites W2012880123 @default.
• W1977976049 cites W2015717266 @default.
• W1977976049 cites W2020262297 @default.
• W1977976049 cites W2024866634 @default.
• W1977976049 cites W2026287451 @default.
• W1977976049 cites W2027176103 @default.
• W1977976049 cites W2029299513 @default.
• W1977976049 cites W2036578336 @default.
• W1977976049 cites W2039263971 @default.
• W1977976049 cites W2055241344 @default.
• W1977976049 cites W2056030494 @default.
• W1977976049 cites W2056198198 @default.
• W1977976049 cites W2072718666 @default.
• W1977976049 cites W2077903158 @default.
• W1977976049 cites W2082490296 @default.
• W1977976049 cites W2084982725 @default.
• W1977976049 cites W2085957678 @default.
• W1977976049 cites W2086798154 @default.
• W1977976049 cites W2089806567 @default.
• W1977976049 cites W2099131447 @default.
• W1977976049 cites W2103513180 @default.
• W1977976049 cites W2108335498 @default.
• W1977976049 cites W2111307782 @default.
• W1977976049 cites W2113291839 @default.
• W1977976049 cites W2113319670 @default.
• W1977976049 cites W2113847305 @default.
• W1977976049 cites W2114750007 @default.
• W1977976049 cites W2124585290 @default.
• W1977976049 cites W2131591099 @default.
• W1977976049 cites W2134907742 @default.
• W1977976049 cites W2144437938 @default.
• W1977976049 cites W2147089471 @default.
• W1977976049 cites W2147446468 @default.
• W1977976049 cites W2148011337 @default.
• W1977976049 cites W2160413407 @default.
• W1977976049 cites W2167355269 @default.
• W1977976049 cites W2167428917 @default.
• W1977976049 cites W2168506147 @default.
• W1977976049 cites W2171565662 @default.
• W1977976049 cites W2325038063 @default.
• W1977976049 doi "https://doi.org/10.1093/brain/awp163" @default.
• W1977976049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3031313" @default.
• W1977976049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19570851" @default.
• W1977976049 hasPublicationYear "2009" @default.
• W1977976049 type Work @default.
• W1977976049 sameAs 1977976049 @default.
• W1977976049 citedByCount "91" @default.
• W1977976049 countsByYear W19779760492012 @default.
• W1977976049 countsByYear W19779760492013 @default.
• W1977976049 countsByYear W19779760492014 @default.
• W1977976049 countsByYear W19779760492015 @default.
• W1977976049 countsByYear W19779760492016 @default.
• W1977976049 countsByYear W19779760492017 @default.
• W1977976049 countsByYear W19779760492018 @default.
• W1977976049 countsByYear W19779760492019 @default.
• W1977976049 countsByYear W19779760492020 @default.
• W1977976049 countsByYear W19779760492021 @default.
• W1977976049 countsByYear W19779760492022 @default.

• next