Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977977555> ?p ?o ?g. }
- W1977977555 endingPage "968" @default.
- W1977977555 startingPage "953" @default.
- W1977977555 abstract "Proteasomal dysfunction may play a role in neurodegenerative conditions and protein aggregation. Overexpression in neuronal cells of alpha-synuclein, a molecule linked to Parkinson's Disease, may lead to proteasomal dysfunction. Using PC12 cells stably expressing wild-type or mutant alpha-synuclein and gel filtration, we demonstrate that soluble, intermediate size oligomers of alpha-synuclein co-elute with the 26S proteasome. These soluble oligomers associate with the 26S proteasome and are significantly increased following treatment with proteasomal, but not lysosomal, inhibitors, indicating specific degradation of these particular species by the 26S proteasome. Importantly, expression of alpha-synuclein resulted in a significant inhibition of all proteasomal activities without affecting the levels or assembly of the 26S proteasome. Pharmacological dissociation of alpha-synuclein oligomers restored proteasomal function and reduced polyubiquitinated protein load in intact cells. Our findings suggest a model where only a subset of specific soluble cell-derived alpha-synuclein oligomers is targeted to the 26S proteasome for degradation, and simultaneously inhibit its function, likely by impeding access of other proteasomal substrates." @default.
- W1977977555 created "2016-06-24" @default.
- W1977977555 creator A5019613030 @default.
- W1977977555 creator A5039096817 @default.
- W1977977555 creator A5089947731 @default.
- W1977977555 date "2010-06-01" @default.
- W1977977555 modified "2023-10-16" @default.
- W1977977555 title "Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome" @default.
- W1977977555 cites W1494109356 @default.
- W1977977555 cites W1503570667 @default.
- W1977977555 cites W1521854746 @default.
- W1977977555 cites W1542125447 @default.
- W1977977555 cites W1565639403 @default.
- W1977977555 cites W1630502818 @default.
- W1977977555 cites W1637321639 @default.
- W1977977555 cites W1904980709 @default.
- W1977977555 cites W1944186563 @default.
- W1977977555 cites W1968957266 @default.
- W1977977555 cites W1971841367 @default.
- W1977977555 cites W1972522869 @default.
- W1977977555 cites W1972939055 @default.
- W1977977555 cites W1977733590 @default.
- W1977977555 cites W1979527613 @default.
- W1977977555 cites W1980393423 @default.
- W1977977555 cites W1991927407 @default.
- W1977977555 cites W1997369314 @default.
- W1977977555 cites W2002223631 @default.
- W1977977555 cites W2009556855 @default.
- W1977977555 cites W2014888545 @default.
- W1977977555 cites W2018836398 @default.
- W1977977555 cites W2021242983 @default.
- W1977977555 cites W2027649342 @default.
- W1977977555 cites W2029000167 @default.
- W1977977555 cites W2032817175 @default.
- W1977977555 cites W2034587793 @default.
- W1977977555 cites W2034887565 @default.
- W1977977555 cites W2038852478 @default.
- W1977977555 cites W2039425688 @default.
- W1977977555 cites W2040863105 @default.
- W1977977555 cites W2041993377 @default.
- W1977977555 cites W2044572180 @default.
- W1977977555 cites W2052098570 @default.
- W1977977555 cites W2057343871 @default.
- W1977977555 cites W2058896572 @default.
- W1977977555 cites W2059382925 @default.
- W1977977555 cites W2068288454 @default.
- W1977977555 cites W2071243806 @default.
- W1977977555 cites W2071995179 @default.
- W1977977555 cites W2073076870 @default.
- W1977977555 cites W2088481573 @default.
- W1977977555 cites W2088733194 @default.
- W1977977555 cites W2090467376 @default.
- W1977977555 cites W2091586455 @default.
- W1977977555 cites W2092791231 @default.
- W1977977555 cites W2095619100 @default.
- W1977977555 cites W2096991937 @default.
- W1977977555 cites W2101362932 @default.
- W1977977555 cites W2104912043 @default.
- W1977977555 cites W2111426001 @default.
- W1977977555 cites W2114245165 @default.
- W1977977555 cites W2116598203 @default.
- W1977977555 cites W2117626437 @default.
- W1977977555 cites W2118518385 @default.
- W1977977555 cites W2121963977 @default.
- W1977977555 cites W2123431154 @default.
- W1977977555 cites W2133272695 @default.
- W1977977555 cites W2144713781 @default.
- W1977977555 cites W2148026632 @default.
- W1977977555 cites W2149320847 @default.
- W1977977555 cites W2154737306 @default.
- W1977977555 cites W2157193371 @default.
- W1977977555 cites W2157535220 @default.
- W1977977555 cites W2170594193 @default.
- W1977977555 cites W2313224625 @default.
- W1977977555 cites W4252368281 @default.
- W1977977555 doi "https://doi.org/10.1016/j.neurobiolaging.2008.07.008" @default.
- W1977977555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18715677" @default.
- W1977977555 hasPublicationYear "2010" @default.
- W1977977555 type Work @default.
- W1977977555 sameAs 1977977555 @default.
- W1977977555 citedByCount "171" @default.
- W1977977555 countsByYear W19779775552012 @default.
- W1977977555 countsByYear W19779775552013 @default.
- W1977977555 countsByYear W19779775552014 @default.
- W1977977555 countsByYear W19779775552015 @default.
- W1977977555 countsByYear W19779775552016 @default.
- W1977977555 countsByYear W19779775552017 @default.
- W1977977555 countsByYear W19779775552018 @default.
- W1977977555 countsByYear W19779775552019 @default.
- W1977977555 countsByYear W19779775552020 @default.
- W1977977555 countsByYear W19779775552021 @default.
- W1977977555 countsByYear W19779775552022 @default.
- W1977977555 countsByYear W19779775552023 @default.
- W1977977555 crossrefType "journal-article" @default.
- W1977977555 hasAuthorship W1977977555A5019613030 @default.
- W1977977555 hasAuthorship W1977977555A5039096817 @default.
- W1977977555 hasAuthorship W1977977555A5089947731 @default.
- W1977977555 hasConcept C104317684 @default.