FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977981331> ?p ?o ?g. }

• W1977981331 endingPage "2018" @default.
• W1977981331 startingPage "2012" @default.
• W1977981331 abstract "The breast- and ovarian-specific tumor suppressor BRCA1 has been implicated in numerous cellular processes, including transcription, ubiquitination, and DNA repair. Its tumor suppression activity is tightly linked to that of BARD1, a protein that heterodimerizes with BRCA1. It has been previously shown that BRCA1 binds to DNA, an interesting functional observation in light of the genetic data linking BRCA1 to DNA repair pathways. In this work, we reexamine the DNA-binding properties of BRCA1, comparing them with the DNA-binding properties of the BRCA1/BARD1 heterodimer. Because nuclear BRCA1 exists as a heterodimer with BARD1, it is likely that in vitro studies of the heterodimer will provide a more accurate model of physiologic conditions. Our results indicate that whereas BARD1 cannot directly bind DNA, it does enhance DNA binding by BRCA1. This is a surprising observation as both DNA-binding domains are distal to the BARD1-interacting RING domain of BRCA1. Further analysis of the dimerization reveals that the BRCA1/BARD1 interaction is not limited to the amino-terminal RING domains of each protein. The carboxyl terminus of BRCA1 contributes significantly to the stability of the heterodimer. We also show that the presence of BARD1 has a secondary effect, as autoubiquitination of BRCA1/BARD1 heterodimers additionally enhances the affinity of BRCA1 for DNA. Together, these data suggest that BRCA1 and BARD1 heterodimerization is stabilized via domains not previously thought to interact and that BARD1 acts in both ubiquitination-dependent and ubiquitination-independent ways to influence the role of BRCA1 in DNA repair." @default.
• W1977981331 created "2016-06-24" @default.
• W1977981331 creator A5009121656 @default.
• W1977981331 creator A5018327095 @default.
• W1977981331 creator A5023251641 @default.
• W1977981331 creator A5058771826 @default.
• W1977981331 creator A5062706548 @default.
• W1977981331 creator A5071126761 @default.
• W1977981331 creator A5080071603 @default.
• W1977981331 date "2006-02-15" @default.
• W1977981331 modified "2023-10-15" @default.
• W1977981331 title "BRCA1 DNA-Binding Activity Is Stimulated by BARD1" @default.
• W1977981331 cites W1529177388 @default.
• W1977981331 cites W1611268078 @default.
• W1977981331 cites W1902704112 @default.
• W1977981331 cites W1969150779 @default.
• W1977981331 cites W1979846193 @default.
• W1977981331 cites W1980438294 @default.
• W1977981331 cites W1981864085 @default.
• W1977981331 cites W1984366469 @default.
• W1977981331 cites W1986627314 @default.
• W1977981331 cites W1994300590 @default.
• W1977981331 cites W1996635873 @default.
• W1977981331 cites W2005284058 @default.
• W1977981331 cites W2006152718 @default.
• W1977981331 cites W2007214871 @default.
• W1977981331 cites W2017714068 @default.
• W1977981331 cites W2019405732 @default.
• W1977981331 cites W2020847285 @default.
• W1977981331 cites W2021798973 @default.
• W1977981331 cites W2024131694 @default.
• W1977981331 cites W2032878080 @default.
• W1977981331 cites W2038260399 @default.
• W1977981331 cites W2044713924 @default.
• W1977981331 cites W2049598883 @default.
• W1977981331 cites W2050061987 @default.
• W1977981331 cites W2051409228 @default.
• W1977981331 cites W2052983166 @default.
• W1977981331 cites W2053003311 @default.
• W1977981331 cites W2059365987 @default.
• W1977981331 cites W2061672761 @default.
• W1977981331 cites W2063954830 @default.
• W1977981331 cites W2064681322 @default.
• W1977981331 cites W2066108933 @default.
• W1977981331 cites W2068638854 @default.
• W1977981331 cites W2075059258 @default.
• W1977981331 cites W2076172602 @default.
• W1977981331 cites W2077858453 @default.
• W1977981331 cites W2105707021 @default.
• W1977981331 cites W2113421653 @default.
• W1977981331 cites W2115517839 @default.
• W1977981331 cites W2127566231 @default.
• W1977981331 cites W2128761168 @default.
• W1977981331 cites W2129169382 @default.
• W1977981331 cites W2138002565 @default.
• W1977981331 cites W2139533668 @default.
• W1977981331 cites W2151736236 @default.
• W1977981331 cites W2164680318 @default.
• W1977981331 cites W2164890615 @default.
• W1977981331 cites W2170278099 @default.
• W1977981331 cites W2326981652 @default.
• W1977981331 cites W2333799845 @default.
• W1977981331 cites W2432429035 @default.
• W1977981331 cites W4232211552 @default.
• W1977981331 doi "https://doi.org/10.1158/0008-5472.can-05-3296" @default.
• W1977981331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16489000" @default.
• W1977981331 hasPublicationYear "2006" @default.
• W1977981331 type Work @default.
• W1977981331 sameAs 1977981331 @default.
• W1977981331 citedByCount "56" @default.
• W1977981331 countsByYear W19779813312012 @default.
• W1977981331 countsByYear W19779813312013 @default.
• W1977981331 countsByYear W19779813312014 @default.
• W1977981331 countsByYear W19779813312015 @default.
• W1977981331 countsByYear W19779813312016 @default.
• W1977981331 countsByYear W19779813312017 @default.
• W1977981331 countsByYear W19779813312018 @default.
• W1977981331 countsByYear W19779813312019 @default.
• W1977981331 countsByYear W19779813312020 @default.
• W1977981331 countsByYear W19779813312021 @default.
• W1977981331 countsByYear W19779813312022 @default.
• W1977981331 countsByYear W19779813312023 @default.
• W1977981331 crossrefType "journal-article" @default.
• W1977981331 hasAuthorship W1977981331A5009121656 @default.
• W1977981331 hasAuthorship W1977981331A5018327095 @default.
• W1977981331 hasAuthorship W1977981331A5023251641 @default.
• W1977981331 hasAuthorship W1977981331A5058771826 @default.
• W1977981331 hasAuthorship W1977981331A5062706548 @default.
• W1977981331 hasAuthorship W1977981331A5071126761 @default.
• W1977981331 hasAuthorship W1977981331A5080071603 @default.
• W1977981331 hasConcept C104317684 @default.
• W1977981331 hasConcept C134935766 @default.
• W1977981331 hasConcept C143425029 @default.
• W1977981331 hasConcept C153911025 @default.
• W1977981331 hasConcept C25602115 @default.
• W1977981331 hasConcept C33987129 @default.
• W1977981331 hasConcept C54355233 @default.
• W1977981331 hasConcept C552990157 @default.

• next