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• W1977984938 endingPage "812" @default.
• W1977984938 startingPage "805" @default.
• W1977984938 abstract "Human immunodeficiency virus (HIV)/AIDS continues to spread worldwide, and most of the HIV-infected people living in developing countries have little or no access to highly active antiretroviral therapy. The development of efficient and low-cost microbicides to prevent sexual transmission of HIV should be given high priority because there is no vaccine available yet. Cyanovirin-N (CVN) is an entry inhibitor of HIV and many other viruses, and it represents a new generation of microbicide that has specific and potent activity, a different mechanism of action, and unusual chemicophysical stability. In vitro and in vivo antiviral tests suggested that the anti-HIV effect of CVN is stronger than a well-known gp120-targeted antibody (2G12) and another microbicide candidate, PRO2000. CVN is a cyanobacteria-derived protein that has special structural features, making the artificial production of this protein very difficult. In order to develop an efficient and relatively low-cost approach for large-scale production of recombinant CVN to satisfy medical use, this protein has been expressed in many systems by trial and error. Here, to summarize the potential and remaining challenges for the development of this protein into an HIV prevention agent, the progress in the structural mechanism determination, heterologous production and pharmacological evaluation of CVN is reviewed." @default.
• W1977984938 created "2016-06-24" @default.
• W1977984938 creator A5041424937 @default.
• W1977984938 creator A5046937271 @default.
• W1977984938 creator A5066962081 @default.
• W1977984938 date "2010-02-17" @default.
• W1977984938 modified "2023-09-26" @default.
• W1977984938 title "The antiviral protein cyanovirin-N: the current state of its production and applications" @default.
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• W1977984938 doi "https://doi.org/10.1007/s00253-010-2470-1" @default.
• W1977984938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20162270" @default.
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