FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977992433> ?p ?o ?g. }

• W1977992433 endingPage "15" @default.
• W1977992433 startingPage "8" @default.
• W1977992433 abstract "X-linked sex-ratio distorters that disrupt spermatogenesis can cause a deficiency in functional Y-bearing sperm and a female-biased sex ratio. Y-linked modifiers that restore a normal sex ratio might be abundant and favored when a X-linked distorter is present. Here we investigated natural variation of Y-linked suppressors of sex-ratio in the Winters systems and the ability of these chromosomes to modulate gene expression in Drosophila simulans. Seventy-eight Y chromosomes of worldwide origin were assayed for their resistance to the X-linked sex-ratio distorter gene Dox. Y chromosome diversity caused males to sire ∼63% to ∼98% female progeny. Genome-wide gene expression analysis revealed hundreds of genes differentially expressed between isogenic males with sensitive (high sex ratio) and resistant (low sex ratio) Y chromosomes from the same population. Although the expression of about 75% of all testis-specific genes remained unchanged across Y chromosomes, a subset of post-meiotic genes was upregulated by resistant Y chromosomes. Conversely, a set of accessory gland-specific genes and mitochondrial genes were downregulated in males with resistant Y chromosomes. The D. simulans Y chromosome also modulated gene expression in XXY females in which the Y-linked protein-coding genes are not transcribed. The data suggest that the Y chromosome might exert its regulatory functions through epigenetic mechanisms that do not require the expression of protein-coding genes. The gene network that modulates sex ratio distortion by the Y chromosome is poorly understood, other than that it might include interactions with mitochondria and enriched for genes expressed in post-meiotic stages of spermatogenesis." @default.
• W1977992433 created "2016-06-24" @default.
• W1977992433 creator A5020961284 @default.
• W1977992433 creator A5038789578 @default.
• W1977992433 creator A5045861406 @default.
• W1977992433 creator A5061240448 @default.
• W1977992433 date "2013-04-17" @default.
• W1977992433 modified "2023-10-10" @default.
• W1977992433 title "Natural variation of the Y chromosome suppresses sex ratio distortion and modulates testis-specific gene expression in Drosophila simulans" @default.
• W1977992433 cites W1831213489 @default.
• W1977992433 cites W1911552456 @default.
• W1977992433 cites W1915398658 @default.
• W1977992433 cites W1934871552 @default.
• W1977992433 cites W1953801165 @default.
• W1977992433 cites W1968050693 @default.
• W1977992433 cites W1973170774 @default.
• W1977992433 cites W1973620047 @default.
• W1977992433 cites W1978031195 @default.
• W1977992433 cites W1978274195 @default.
• W1977992433 cites W1986309262 @default.
• W1977992433 cites W1991072105 @default.
• W1977992433 cites W1991531009 @default.
• W1977992433 cites W1993827187 @default.
• W1977992433 cites W1996643053 @default.
• W1977992433 cites W1998700100 @default.
• W1977992433 cites W2001785571 @default.
• W1977992433 cites W2004000260 @default.
• W1977992433 cites W2006662323 @default.
• W1977992433 cites W2007856267 @default.
• W1977992433 cites W2013444425 @default.
• W1977992433 cites W2014931922 @default.
• W1977992433 cites W2027318023 @default.
• W1977992433 cites W2030390608 @default.
• W1977992433 cites W2049916583 @default.
• W1977992433 cites W2057234957 @default.
• W1977992433 cites W2057589481 @default.
• W1977992433 cites W2062731459 @default.
• W1977992433 cites W2071550940 @default.
• W1977992433 cites W2072685613 @default.
• W1977992433 cites W2075803808 @default.
• W1977992433 cites W2080919144 @default.
• W1977992433 cites W2096052762 @default.
• W1977992433 cites W2103229988 @default.
• W1977992433 cites W2108626125 @default.
• W1977992433 cites W2109427473 @default.
• W1977992433 cites W2112867025 @default.
• W1977992433 cites W2114721511 @default.
• W1977992433 cites W2122555950 @default.
• W1977992433 cites W2122778867 @default.
• W1977992433 cites W2123627511 @default.
• W1977992433 cites W2124830403 @default.
• W1977992433 cites W2126615487 @default.
• W1977992433 cites W2129782171 @default.
• W1977992433 cites W2131768903 @default.
• W1977992433 cites W2134010732 @default.
• W1977992433 cites W2136858512 @default.
• W1977992433 cites W2138029294 @default.
• W1977992433 cites W2138107312 @default.
• W1977992433 cites W2144561973 @default.
• W1977992433 cites W2151374010 @default.
• W1977992433 cites W2157376474 @default.
• W1977992433 cites W2162584510 @default.
• W1977992433 cites W2163623853 @default.
• W1977992433 cites W2164581964 @default.
• W1977992433 cites W2164862488 @default.
• W1977992433 cites W2166252054 @default.
• W1977992433 cites W2167496283 @default.
• W1977992433 cites W2170340195 @default.
• W1977992433 cites W2170700353 @default.
• W1977992433 cites W2171297609 @default.
• W1977992433 cites W2172076792 @default.
• W1977992433 cites W2186079474 @default.
• W1977992433 cites W2318831603 @default.
• W1977992433 cites W2409425950 @default.
• W1977992433 doi "https://doi.org/10.1038/hdy.2013.5" @default.
• W1977992433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3692315" @default.
• W1977992433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23591516" @default.
• W1977992433 hasPublicationYear "2013" @default.
• W1977992433 type Work @default.
• W1977992433 sameAs 1977992433 @default.
• W1977992433 citedByCount "33" @default.
• W1977992433 countsByYear W19779924332014 @default.
• W1977992433 countsByYear W19779924332015 @default.
• W1977992433 countsByYear W19779924332016 @default.
• W1977992433 countsByYear W19779924332017 @default.
• W1977992433 countsByYear W19779924332018 @default.
• W1977992433 countsByYear W19779924332019 @default.
• W1977992433 countsByYear W19779924332020 @default.
• W1977992433 countsByYear W19779924332021 @default.
• W1977992433 countsByYear W19779924332022 @default.
• W1977992433 countsByYear W19779924332023 @default.
• W1977992433 crossrefType "journal-article" @default.
• W1977992433 hasAuthorship W1977992433A5020961284 @default.
• W1977992433 hasAuthorship W1977992433A5038789578 @default.
• W1977992433 hasAuthorship W1977992433A5045861406 @default.
• W1977992433 hasAuthorship W1977992433A5061240448 @default.
• W1977992433 hasBestOaLocation W19779924332 @default.
• W1977992433 hasConcept C104317684 @default.

• next