FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978000554> ?p ?o ?g. }

• W1978000554 abstract "Several methods to identify tagging single-nucleotide polymorphisms (SNPs) are in common use for genetic epidemiologic studies; however, there may be loss of information when using only a subset of SNPs. We sought to compare the ability of commonly used pairwise, multimarker, and haplotype-based tagging SNP selection methods to detect known associations with quantitative expression phenotypes. Using data from HapMap release 21 on unrelated Utah residents with ancestors from northern and western Europe (CEPH-Utah, CEU), we selected tagging SNPs in five chromosomal regions using ldSelect, Tagger, and TagSNPs. We found that SNP subsets did not substantially overlap, and that the use of trio data did not greatly impact SNP selection. We then tested associations between HapMap genotypes and expression phenotypes on 28 CEU individuals as part of Genetic Analysis Workshop 15. Relative to the use of all SNPs (n = 210 SNPs across all regions), most subset methods were able to detect single-SNP and haplotype associations. Generally, pairwise selection approaches worked extremely well, relative to use of all SNPs, with marked reductions in the number of SNPs required. Haplotype-based approaches, which had identified smaller SNP subsets, missed associations in some regions. We conclude that the optimal tagging SNP method depends on the true model of the genetic association (i.e., whether a SNP or haplotype is responsible); unfortunately, this is often unknown at the time of SNP selection. Additional evaluations using empirical and simulated data are needed." @default.
• W1978000554 created "2016-06-24" @default.
• W1978000554 creator A5004055647 @default.
• W1978000554 creator A5014184022 @default.
• W1978000554 creator A5038589760 @default.
• W1978000554 creator A5038946006 @default.
• W1978000554 creator A5050039580 @default.
• W1978000554 creator A5059340927 @default.
• W1978000554 creator A5067100969 @default.
• W1978000554 creator A5077162710 @default.
• W1978000554 creator A5088358437 @default.
• W1978000554 date "2007-12-01" @default.
• W1978000554 modified "2023-09-24" @default.
• W1978000554 title "Comparison of tagging single-nucleotide polymorphism methods in association analyses" @default.
• W1978000554 cites W1984658341 @default.
• W1978000554 cites W2001476776 @default.
• W1978000554 cites W2015408724 @default.
• W1978000554 cites W2030067801 @default.
• W1978000554 cites W2060181803 @default.
• W1978000554 cites W2067245109 @default.
• W1978000554 cites W2090430326 @default.
• W1978000554 cites W2138496671 @default.
• W1978000554 cites W2146809629 @default.
• W1978000554 cites W2155635136 @default.
• W1978000554 cites W2159152816 @default.
• W1978000554 cites W2159184027 @default.
• W1978000554 cites W2167153733 @default.
• W1978000554 cites W2217809488 @default.
• W1978000554 doi "https://doi.org/10.1186/1753-6561-1-s1-s6" @default.
• W1978000554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2367496" @default.
• W1978000554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18466560" @default.
• W1978000554 hasPublicationYear "2007" @default.
• W1978000554 type Work @default.
• W1978000554 sameAs 1978000554 @default.
• W1978000554 citedByCount "9" @default.
• W1978000554 countsByYear W19780005542012 @default.
• W1978000554 countsByYear W19780005542013 @default.
• W1978000554 crossrefType "journal-article" @default.
• W1978000554 hasAuthorship W1978000554A5004055647 @default.
• W1978000554 hasAuthorship W1978000554A5014184022 @default.
• W1978000554 hasAuthorship W1978000554A5038589760 @default.
• W1978000554 hasAuthorship W1978000554A5038946006 @default.
• W1978000554 hasAuthorship W1978000554A5050039580 @default.
• W1978000554 hasAuthorship W1978000554A5059340927 @default.
• W1978000554 hasAuthorship W1978000554A5067100969 @default.
• W1978000554 hasAuthorship W1978000554A5077162710 @default.
• W1978000554 hasAuthorship W1978000554A5088358437 @default.
• W1978000554 hasBestOaLocation W19780005541 @default.
• W1978000554 hasConcept C104317684 @default.
• W1978000554 hasConcept C135763542 @default.
• W1978000554 hasConcept C137132547 @default.
• W1978000554 hasConcept C139275648 @default.
• W1978000554 hasConcept C153209595 @default.
• W1978000554 hasConcept C154945302 @default.
• W1978000554 hasConcept C163691529 @default.
• W1978000554 hasConcept C177580304 @default.
• W1978000554 hasConcept C184898388 @default.
• W1978000554 hasConcept C186413461 @default.
• W1978000554 hasConcept C197754878 @default.
• W1978000554 hasConcept C41008148 @default.
• W1978000554 hasConcept C54355233 @default.
• W1978000554 hasConcept C55060382 @default.
• W1978000554 hasConcept C70721500 @default.
• W1978000554 hasConcept C81917197 @default.
• W1978000554 hasConcept C86803240 @default.
• W1978000554 hasConceptScore W1978000554C104317684 @default.
• W1978000554 hasConceptScore W1978000554C135763542 @default.
• W1978000554 hasConceptScore W1978000554C137132547 @default.
• W1978000554 hasConceptScore W1978000554C139275648 @default.
• W1978000554 hasConceptScore W1978000554C153209595 @default.
• W1978000554 hasConceptScore W1978000554C154945302 @default.
• W1978000554 hasConceptScore W1978000554C163691529 @default.
• W1978000554 hasConceptScore W1978000554C177580304 @default.
• W1978000554 hasConceptScore W1978000554C184898388 @default.
• W1978000554 hasConceptScore W1978000554C186413461 @default.
• W1978000554 hasConceptScore W1978000554C197754878 @default.
• W1978000554 hasConceptScore W1978000554C41008148 @default.
• W1978000554 hasConceptScore W1978000554C54355233 @default.
• W1978000554 hasConceptScore W1978000554C55060382 @default.
• W1978000554 hasConceptScore W1978000554C70721500 @default.
• W1978000554 hasConceptScore W1978000554C81917197 @default.
• W1978000554 hasConceptScore W1978000554C86803240 @default.
• W1978000554 hasIssue "S1" @default.
• W1978000554 hasLocation W19780005541 @default.
• W1978000554 hasLocation W19780005542 @default.
• W1978000554 hasLocation W19780005543 @default.
• W1978000554 hasLocation W19780005544 @default.
• W1978000554 hasLocation W19780005545 @default.
• W1978000554 hasOpenAccess W1978000554 @default.
• W1978000554 hasPrimaryLocation W19780005541 @default.
• W1978000554 hasRelatedWork W1966708416 @default.
• W1978000554 hasRelatedWork W1978000554 @default.
• W1978000554 hasRelatedWork W2017507057 @default.
• W1978000554 hasRelatedWork W2021147140 @default.
• W1978000554 hasRelatedWork W2064710833 @default.
• W1978000554 hasRelatedWork W2071146638 @default.
• W1978000554 hasRelatedWork W2104912262 @default.
• W1978000554 hasRelatedWork W2143999835 @default.
• W1978000554 hasRelatedWork W2146809629 @default.
• W1978000554 hasRelatedWork W2387863712 @default.

• next