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- W1978004587 abstract "Propionate of vitamin A (PVA) is a highly instable and poorly water-soluble molecule which is of real interest for therapeutics. 1:1 γ CD/PVA and 2:1 β CD/PVA inclusion complexes are formed. A stability study using NMR and HPLC indicated that β CD induced an accelerated degradation of PVA but, conversely γ CD could protect it efficiently for many months. A very stable and soluble complex can be formed between heptakis(2,6-di- O-methyl)cyclomaltoheptaose (Dimeb) and vitamin A propionate. This solution was used to form an aqueous gel. The skin absorption of PVA and Dimeb through the stratum corneum, epidermis and the dermis of human skin were assayed by HPLC and by specific immunoassays, respectively. In presence of Dimeb, the amounts of PVA inside the different skins were significantly higher. It was also demonstrated that Dimeb penetrated in every cutaneous layer and showed no significant difference between free and bound forms." @default.
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- W1978004587 date "2004-01-01" @default.
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- W1978004587 title "Enhancement of vitamin A skin absorption by cyclodextrins" @default.
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- W1978004587 doi "https://doi.org/10.1016/s1773-2247(04)50009-6" @default.
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