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• W1978006498 abstract "Tourniquet-imposed ischemia-reperfusion of extremities generates reactive oxygen and nitrogen species (RONS), which can disrupt intermediary metabolism and ATP production. This study tested the hypothesis that fluid resuscitation with pyruvate, a natural antioxidant and metabolic fuel, ameliorates the deleterious effects of ischemia-reperfusion on intermediary metabolism in skeletal muscle. Anesthetized male goats (∼25 kg) were bled to a mean arterial pressure of 48 ± 1 mmHg and then subjected to 90 min hindlimb ischemia with a tourniquet and femoral crossclamp, followed by 4-h reperfusion. Lactated Ringers (LR) or pyruvate Ringers (PR) was infused intravenous for 90 min, from 30 min ischemia to 30 min reperfusion, to deliver 0.05 mmol kg −1 min −1 lactate or pyruvate. Time controls (TC) underwent neither hemorrhage nor hindlimb ischemia. Lipid peroxidation product 8-isoprostane, RONS-sensitive aconitase and creatine kinase activities, antioxidant superoxide dismutase activity, and phosphocreatine phosphorylation potential ([PCr]/[{Cr}{P i }]), an index of tissue energy state, were measured in reperfused gastrocnemius at 90 min resuscitation ( n = 6 all groups) and 3.5 h post-resuscitation ( n = 8 TC, 9 LR, 10 PR). PR more effectively than LR suppressed 8-isoprostane formation, prevented inactivation of aconitase and creatine kinase, doubled superoxide dismutase activity, and augmented [PCr]/([Cr][P i ]). Pyruvate-enriched Ringer’s is metabolically superior to Ringer’s lactate for fluid resuscitation of tourniqueted muscle." @default.
• W1978006498 created "2016-06-24" @default.
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• W1978006498 date "2014-01-10" @default.
• W1978006498 modified "2023-09-27" @default.
• W1978006498 title "Pyruvate-enriched resuscitation: metabolic support of post-ischemic hindlimb muscle in hypovolemic goats" @default.
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• W1978006498 doi "https://doi.org/10.1177/1535370213514329" @default.
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