FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978007817> ?p ?o ?g. }

• W1978007817 endingPage "747" @default.
• W1978007817 startingPage "740" @default.
• W1978007817 abstract "Positron-emission tomography (PET) employing fluorodeoxyglucose (FDG) has proven to be a highly sensitive and specific diagnostic method in the staging and restaging of various neoplasms, including melanoma, complementing morphologic imaging. FDG uptake has been correlated with proliferation rate, and thus, the degree of malignancy of a given tumor (i.e., grading). Consecutively, a relationship of survival prognosis and the extent of tumor burden as well as degree of FDG accumulation—determined by FDG-PET— has been suggested in various tumors. The aim of this study was to assess the potential of fluor-18-FDG-PET in order to evaluate the survival prognosis in melanoma. Patient data (n = 95) were retrospectively analyzed, and the results of functional FDG-PET staging was correlated with survival data. Time of staging (diagnosis of primary versus recurrence) had no statistically significant effect on survival prognosis when patients were matched for pertaining node metastasis (NM) stages. Differences in survival were owing to the presence of metastatic disease rather than time of staging. Tumor (T)-stage (T1–T4) alone had no effect on survival prognosis when patients were matched for NM stages. Differences in survival were also due to higher rates of lymph node (LN) and organ metastases in higher T-stages. Detection of LN metastases (N1M0) had a statistically significant and predominant impact on 5-year survival (N0M0 80% versus N1M0 45%; p < 0.01). Additional presence of distant metastases in LN-positive patients (N1M1) had only a statistically insignificant further impact on survival (5-year survival in N1M0 45% versus N1M1 29%; p > 0.05). Exclusive presence of organ metastases (N0M1) showed a statistically significant drop of survival with a 5-year survival of 61% in N0M1 versus 80% in N0M0, respectively (p < 0.03). Further, the combined presence of LN and distant metastases had the worst prognosis (5-year survival in N1M1 29% versus N0M1 61%; p < 0.02). Based on a qualitative 4-point scoring system, patients with malignancy-typical FDG uptake showed an overall 5-year survival of 38%, as compared to patients with malignancy-suspicious lesions (71%; p ≤ 0.02) or patients without evidence of disease (80%; p < 0.001). When PET and computed tomography (CT) findings were compared, survival was best in patients with both studies (CT and PET) being negative (5-year survival, 83%), worst when PET and CT were positive (5-year survival, 61%; p < 0.02), and showed an intermediate survival when PET was positive, but with CT still negative (5-year survival, 73%). In patients staged by FDG-PET, significant risk factors—as identified by univariate und multivariate analyses—were (i) malignancy-typical FDG uptake, (ii) detection of LN, and (iii) organ metastases. In conclusion, FDG-PET offers valid prognostic information, demonstrating a good relationship of functional TNM-stage and actual survival prognosis. The results obtained in one PET study seem to be as suitable as the combined results of conventional staging, including clinical and morphologic (e.g., CT) methods and clinical follow-up. FDG-PET was more accurate in tumor detection and seemed to detect tumor spread earlier, as compared to CT." @default.
• W1978007817 created "2016-06-24" @default.
• W1978007817 creator A5033952552 @default.
• W1978007817 creator A5041961052 @default.
• W1978007817 creator A5062927748 @default.
• W1978007817 creator A5082501639 @default.
• W1978007817 date "2007-12-01" @default.
• W1978007817 modified "2023-09-27" @default.
• W1978007817 title "Role of FDG-PET in the Assessment of Survival Prognosis in Melanoma" @default.
• W1978007817 cites W1919811975 @default.
• W1978007817 cites W1967993341 @default.
• W1978007817 cites W1972579742 @default.
• W1978007817 cites W1974483691 @default.
• W1978007817 cites W1980199015 @default.
• W1978007817 cites W1986709694 @default.
• W1978007817 cites W2004592504 @default.
• W1978007817 cites W2015234005 @default.
• W1978007817 cites W2047181127 @default.
• W1978007817 cites W2071765362 @default.
• W1978007817 cites W2182467204 @default.
• W1978007817 cites W2915822078 @default.
• W1978007817 cites W3180270935 @default.
• W1978007817 doi "https://doi.org/10.1089/cbr.2006.356" @default.
• W1978007817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18158764" @default.
• W1978007817 hasPublicationYear "2007" @default.
• W1978007817 type Work @default.
• W1978007817 sameAs 1978007817 @default.
• W1978007817 citedByCount "20" @default.
• W1978007817 countsByYear W19780078172012 @default.
• W1978007817 countsByYear W19780078172013 @default.
• W1978007817 countsByYear W19780078172015 @default.
• W1978007817 countsByYear W19780078172016 @default.
• W1978007817 countsByYear W19780078172018 @default.
• W1978007817 countsByYear W19780078172019 @default.
• W1978007817 countsByYear W19780078172022 @default.
• W1978007817 crossrefType "journal-article" @default.
• W1978007817 hasAuthorship W1978007817A5033952552 @default.
• W1978007817 hasAuthorship W1978007817A5041961052 @default.
• W1978007817 hasAuthorship W1978007817A5062927748 @default.
• W1978007817 hasAuthorship W1978007817A5082501639 @default.
• W1978007817 hasConcept C10515644 @default.
• W1978007817 hasConcept C121608353 @default.
• W1978007817 hasConcept C126322002 @default.
• W1978007817 hasConcept C126838900 @default.
• W1978007817 hasConcept C127413603 @default.
• W1978007817 hasConcept C143998085 @default.
• W1978007817 hasConcept C146357865 @default.
• W1978007817 hasConcept C147176958 @default.
• W1978007817 hasConcept C151730666 @default.
• W1978007817 hasConcept C2775842073 @default.
• W1978007817 hasConcept C2776283816 @default.
• W1978007817 hasConcept C2777286243 @default.
• W1978007817 hasConcept C2777415128 @default.
• W1978007817 hasConcept C2777658100 @default.
• W1978007817 hasConcept C2779013556 @default.
• W1978007817 hasConcept C2779399171 @default.
• W1978007817 hasConcept C2780849966 @default.
• W1978007817 hasConcept C2989005 @default.
• W1978007817 hasConcept C3019894029 @default.
• W1978007817 hasConcept C3019926457 @default.
• W1978007817 hasConcept C502942594 @default.
• W1978007817 hasConcept C71924100 @default.
• W1978007817 hasConcept C86803240 @default.
• W1978007817 hasConceptScore W1978007817C10515644 @default.
• W1978007817 hasConceptScore W1978007817C121608353 @default.
• W1978007817 hasConceptScore W1978007817C126322002 @default.
• W1978007817 hasConceptScore W1978007817C126838900 @default.
• W1978007817 hasConceptScore W1978007817C127413603 @default.
• W1978007817 hasConceptScore W1978007817C143998085 @default.
• W1978007817 hasConceptScore W1978007817C146357865 @default.
• W1978007817 hasConceptScore W1978007817C147176958 @default.
• W1978007817 hasConceptScore W1978007817C151730666 @default.
• W1978007817 hasConceptScore W1978007817C2775842073 @default.
• W1978007817 hasConceptScore W1978007817C2776283816 @default.
• W1978007817 hasConceptScore W1978007817C2777286243 @default.
• W1978007817 hasConceptScore W1978007817C2777415128 @default.
• W1978007817 hasConceptScore W1978007817C2777658100 @default.
• W1978007817 hasConceptScore W1978007817C2779013556 @default.
• W1978007817 hasConceptScore W1978007817C2779399171 @default.
• W1978007817 hasConceptScore W1978007817C2780849966 @default.
• W1978007817 hasConceptScore W1978007817C2989005 @default.
• W1978007817 hasConceptScore W1978007817C3019894029 @default.
• W1978007817 hasConceptScore W1978007817C3019926457 @default.
• W1978007817 hasConceptScore W1978007817C502942594 @default.
• W1978007817 hasConceptScore W1978007817C71924100 @default.
• W1978007817 hasConceptScore W1978007817C86803240 @default.
• W1978007817 hasIssue "6" @default.
• W1978007817 hasLocation W19780078171 @default.
• W1978007817 hasLocation W19780078172 @default.
• W1978007817 hasOpenAccess W1978007817 @default.
• W1978007817 hasPrimaryLocation W19780078171 @default.
• W1978007817 hasRelatedWork W1978007817 @default.
• W1978007817 hasRelatedWork W2005291918 @default.
• W1978007817 hasRelatedWork W2024361430 @default.
• W1978007817 hasRelatedWork W2364092196 @default.
• W1978007817 hasRelatedWork W2413940477 @default.
• W1978007817 hasRelatedWork W2442232449 @default.
• W1978007817 hasRelatedWork W2610561603 @default.

• next