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- W1978009416 abstract "Abstract The essential biologically functional components of a model system for study of the reduction of p -nitrobenzoic acid (PNBA) to p -aminobenzoic acid (PABA) appeared to include: reduced nicotinamide adenine dinucleotide phosphate (NADPH) or reduced nicotinamide adenine dinucleotide (NADH) as initial electron donors, a flavin [flavin adenine dinucleotide (FAD), riboflavin-5-phosphate (FMN) or riboflavin], a sulfhydryl donor [e.g. reduced glutathione, (GSH) or cysteine] and a salt. The effects of the flavins and GSH were biphasic, showing activation in lower concentrations but inhibition in higher concentrations. The salt requirement appeared to be essential for the provision of optimal ionic strength. Variations of components of the model system increased the reaction rate to only about one-tenth that observed in the presence of boiled, dialyzed human placental or rat hepatic 104,000 g supernatant fractions. The reaction was inhibited (approximately 90 per cent) by carbon monoxide (CO) in incubation flasks containing boiled placental soluble fractions but was not inhibited by CO in model system reactions. Addition of 2.5 × 10 −3 M FMN to reaction vessels containing fresh, nondialyzed rat liver 104,000 g supernatant fractions markedly enhanced the reaction rate but addition of the same concentrations (inhibitory in model systems) to vessels containing dialyzed rat liver supernatant markedly inhibited the reaction. The results suggested differing mechanisms of electron transport from NADPH or NADH to PNBA for each of the various tissues studied as well as for homogenate subfractions of a given tissue." @default.
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- W1978009416 date "1970-02-01" @default.
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- W1978009416 title "Model systems for aromatic nitro group reduction—Relationships to tissue catalyzed reagents" @default.
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- W1978009416 doi "https://doi.org/10.1016/0006-2952(70)90200-5" @default.
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