Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978010170> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1978010170 endingPage "62" @default.
- W1978010170 startingPage "56" @default.
- W1978010170 abstract "Asterriquinone (ARQ; 2,5-bis-[1'-(1, 1-dimethyl-2-propenyl)- indol-3'-yl]-3,6-dihydroxy-1,4-benzoquinone) and its three analogues [i.e., 3,6-dihydroxy-2-[2'-(1, 1-dimethyl-2-propenyl)-indol-3'-yl]-5-[1', 7'- (1,1-dimethylpropano)-indol-3'-yl]-1,4-benzoquinone (B1-4), 3,6-dihydroxy-2-[2'-(1, 1-dimethyl-2-propenyl)-indol-3'-yl]-5-indol-3'-yl-1,4-benzoquinone (C1-1) and 3,6-dihydroxy-2,5-diindol-3'-yl-1,4-benzoquinone (D-1)] were found to be strong inhibitors of the activity of reverse transcriptase from human immunodeficiency virus type-1. Under the reaction conditions employed, the enzyme activity was inhibited by more than 70% in the presence of 10 microM each of these compounds. The mode of inhibition by these compounds was competitive with respect to the template.primer, (rA)n.(dT)12-18, and noncompetitive with respect to the triphosphate substrate, dTTP. The Ki values of HIV-1 reverse transcriptase were determined to be 2.3, 1.5, 0.1 and 0.3 microM for ARQ, B1-4, C1-1 and D-1, respectively." @default.
- W1978010170 created "2016-06-24" @default.
- W1978010170 creator A5006709303 @default.
- W1978010170 creator A5015026719 @default.
- W1978010170 creator A5017959526 @default.
- W1978010170 creator A5080104770 @default.
- W1978010170 date "1991-01-01" @default.
- W1978010170 modified "2023-09-26" @default.
- W1978010170 title "Inhibition of HIV-reverse transcriptase activity by asterriquinone and its analogues" @default.
- W1978010170 cites W1532977449 @default.
- W1978010170 cites W1967946050 @default.
- W1978010170 cites W1969918847 @default.
- W1978010170 cites W1983732112 @default.
- W1978010170 cites W2008745326 @default.
- W1978010170 cites W2027861910 @default.
- W1978010170 cites W2034793083 @default.
- W1978010170 cites W2044898848 @default.
- W1978010170 cites W2069952759 @default.
- W1978010170 cites W2080920468 @default.
- W1978010170 cites W2088166099 @default.
- W1978010170 cites W2102973576 @default.
- W1978010170 cites W2143788821 @default.
- W1978010170 cites W2152270852 @default.
- W1978010170 cites W4244325755 @default.
- W1978010170 cites W4256221661 @default.
- W1978010170 doi "https://doi.org/10.1016/0006-291x(91)90484-o" @default.
- W1978010170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1703412" @default.
- W1978010170 hasPublicationYear "1991" @default.
- W1978010170 type Work @default.
- W1978010170 sameAs 1978010170 @default.
- W1978010170 citedByCount "17" @default.
- W1978010170 countsByYear W19780101702016 @default.
- W1978010170 countsByYear W19780101702017 @default.
- W1978010170 countsByYear W19780101702018 @default.
- W1978010170 countsByYear W19780101702020 @default.
- W1978010170 countsByYear W19780101702021 @default.
- W1978010170 countsByYear W19780101702022 @default.
- W1978010170 countsByYear W19780101702023 @default.
- W1978010170 crossrefType "journal-article" @default.
- W1978010170 hasAuthorship W1978010170A5006709303 @default.
- W1978010170 hasAuthorship W1978010170A5015026719 @default.
- W1978010170 hasAuthorship W1978010170A5017959526 @default.
- W1978010170 hasAuthorship W1978010170A5080104770 @default.
- W1978010170 hasConcept C104317684 @default.
- W1978010170 hasConcept C156719811 @default.
- W1978010170 hasConcept C159047783 @default.
- W1978010170 hasConcept C178790620 @default.
- W1978010170 hasConcept C181199279 @default.
- W1978010170 hasConcept C185592680 @default.
- W1978010170 hasConcept C18903297 @default.
- W1978010170 hasConcept C2777289219 @default.
- W1978010170 hasConcept C2777563447 @default.
- W1978010170 hasConcept C2779686393 @default.
- W1978010170 hasConcept C3013748606 @default.
- W1978010170 hasConcept C55493867 @default.
- W1978010170 hasConcept C67705224 @default.
- W1978010170 hasConcept C71240020 @default.
- W1978010170 hasConcept C86803240 @default.
- W1978010170 hasConceptScore W1978010170C104317684 @default.
- W1978010170 hasConceptScore W1978010170C156719811 @default.
- W1978010170 hasConceptScore W1978010170C159047783 @default.
- W1978010170 hasConceptScore W1978010170C178790620 @default.
- W1978010170 hasConceptScore W1978010170C181199279 @default.
- W1978010170 hasConceptScore W1978010170C185592680 @default.
- W1978010170 hasConceptScore W1978010170C18903297 @default.
- W1978010170 hasConceptScore W1978010170C2777289219 @default.
- W1978010170 hasConceptScore W1978010170C2777563447 @default.
- W1978010170 hasConceptScore W1978010170C2779686393 @default.
- W1978010170 hasConceptScore W1978010170C3013748606 @default.
- W1978010170 hasConceptScore W1978010170C55493867 @default.
- W1978010170 hasConceptScore W1978010170C67705224 @default.
- W1978010170 hasConceptScore W1978010170C71240020 @default.
- W1978010170 hasConceptScore W1978010170C86803240 @default.
- W1978010170 hasIssue "1" @default.
- W1978010170 hasLocation W19780101701 @default.
- W1978010170 hasLocation W19780101702 @default.
- W1978010170 hasOpenAccess W1978010170 @default.
- W1978010170 hasPrimaryLocation W19780101701 @default.
- W1978010170 hasRelatedWork W1627951033 @default.
- W1978010170 hasRelatedWork W1972399114 @default.
- W1978010170 hasRelatedWork W2018944361 @default.
- W1978010170 hasRelatedWork W2023644431 @default.
- W1978010170 hasRelatedWork W2034458000 @default.
- W1978010170 hasRelatedWork W2088954468 @default.
- W1978010170 hasRelatedWork W2322713371 @default.
- W1978010170 hasRelatedWork W2351603354 @default.
- W1978010170 hasRelatedWork W4312363656 @default.
- W1978010170 hasRelatedWork W2610973663 @default.
- W1978010170 hasVolume "174" @default.
- W1978010170 isParatext "false" @default.
- W1978010170 isRetracted "false" @default.
- W1978010170 magId "1978010170" @default.
- W1978010170 workType "article" @default.