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- W1978012161 abstract "Multidrug resistance is a serious problem in current chemotherapy. The efflux system largely responsible for resistance in Escherichia coli contains the drug transporter, AcrB. The structures of AcrB were solved in 2002 as the symmetric homo-trimer, and then in 2006 as the asymmetric homo-trimer. The latter suggested a functionally rotating mechanism. Here, by molecular simulations of the AcrB porter domain, we uncovered allosteric coupling and the drug export mechanism in the AcrB trimer. Allosteric coupling stabilized the asymmetric structure with one drug molecule bound, which validated the modelling. Drug dissociation caused a conformational change and stabilized the symmetric structure, providing a unified view of the structures reported in 2002 and 2006. A dynamic study suggested that, among the three potential driving processes, only protonation of the drug-bound protomer can drive the functional rotation and simultaneously export the drug. The drug transporter AcrB is a component of the tripartite efflux system AcrB–AcrA–TolC, which is important in multidrug-resistantEscherichia coli. Takada and co-workers used molecular simulations to further reveal the mechanism of drug export." @default.
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- W1978012161 date "2010-11-16" @default.
- W1978012161 modified "2023-09-30" @default.
- W1978012161 title "Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations" @default.
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- W1978012161 doi "https://doi.org/10.1038/ncomms1116" @default.
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