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• W1978012920 abstract "The AHNAK scaffold PDZ-protein family is implicated in various cellular processes including membrane repair; however, AHNAK function and subcellular localization in skeletal muscle are unclear. We used specific AHNAK1 and AHNAK2 antibodies to analyzed the detailed localization of both proteins in mouse skeletal muscle. Co-localization of AHNAK1 and AHNAK2 with vinculin clearly demonstrates that both proteins are components of the costameric network. In contrast, no AHNAK expression was detected in the T-tubule system. A laser wounding assay with AHNAK1-deficient fibers suggests that AHNAK1 is not involved in membrane repair. Using atomic force microscopy (AFM), we observed a significantly higher transverse stiffness of AHNAK1−/− fibers. These findings suggest novel functions of AHNAK proteins in skeletal muscle." @default.
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• W1978012920 date "2010-10-01" @default.
• W1978012920 modified "2023-10-18" @default.
• W1978012920 title "AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness" @default.
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• W1978012920 doi "https://doi.org/10.1016/j.bbrc.2010.09.030" @default.
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