FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978013225> ?p ?o ?g. }

• W1978013225 endingPage "13" @default.
• W1978013225 startingPage "8" @default.
• W1978013225 abstract "Treatment of a pathological spinal disc in vivo by injection of protein crosslinking reagents to restore the disc's mechanical properties is a new approach to the treatment of degenerative disc disease. In this study, the thermal stability of the collagen in disc annulus was measured by differential scanning calorimetry following treatment with six different crosslinking agents. The crosslinkers used were; L-threose (LT), genipin (GP), methylglyoxal (MG), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), glutaraldehyde (GA), and proanthrocyanidin (PA). Untreated tissue displayed a prominent peak at about 66–68°C. Comparison of endothermal patterns of untreated and crosslinker-treated disc annulus tissue samples showed that a new peak appeared at a higher temperature following treatment. The temperature of the new peak qualitatively depended on the crosslinker in the following order GA > MG > GP > PA = EDC > LT, suggesting that the enhanced thermal stability of collagen in the annulus tissue was related to the nature of the crosslinker. Also, the enthalpic ratios of the lower temperature (noncrosslinked) peaks in the treated and untreated tissue, and of the higher and lower temperature peaks in the treated tissue, both indicated that the various agents crosslinked the tissue with different efficiencies. Our data suggest that the ability of GP to penetrate into the disc and form long- and short-range crosslinks may make it the most suitable candidate for clinical development. In addition, binary combinations of long- and short-range crosslinkers, such as PA with LT, may also provide synergistic effects due to their substantially different physicochemical properties. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:8–13, 2011" @default.
• W1978013225 created "2016-06-24" @default.
• W1978013225 creator A5039596150 @default.
• W1978013225 creator A5070245671 @default.
• W1978013225 creator A5070654670 @default.
• W1978013225 date "2010-11-22" @default.
• W1978013225 modified "2023-10-18" @default.
• W1978013225 title "Thermal analysis reveals differential effects of various crosslinkers on bovine annulus fibrosis" @default.
• W1978013225 cites W143623202 @default.
• W1978013225 cites W1965978247 @default.
• W1978013225 cites W1971280448 @default.
• W1978013225 cites W1980036479 @default.
• W1978013225 cites W1984453539 @default.
• W1978013225 cites W1996622256 @default.
• W1978013225 cites W2004451065 @default.
• W1978013225 cites W2013259546 @default.
• W1978013225 cites W2015551486 @default.
• W1978013225 cites W2018376286 @default.
• W1978013225 cites W2029998005 @default.
• W1978013225 cites W2034350312 @default.
• W1978013225 cites W2045161164 @default.
• W1978013225 cites W2054270773 @default.
• W1978013225 cites W2059100011 @default.
• W1978013225 cites W2060089538 @default.
• W1978013225 cites W2067162794 @default.
• W1978013225 cites W2073104182 @default.
• W1978013225 cites W2075056504 @default.
• W1978013225 cites W2094675130 @default.
• W1978013225 cites W2100261886 @default.
• W1978013225 cites W2123311131 @default.
• W1978013225 cites W2152983876 @default.
• W1978013225 cites W2169558926 @default.
• W1978013225 cites W2170905973 @default.
• W1978013225 cites W2214110491 @default.
• W1978013225 cites W2416171442 @default.
• W1978013225 cites W283541855 @default.
• W1978013225 doi "https://doi.org/10.1002/jor.21189" @default.
• W1978013225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3154730" @default.
• W1978013225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20589930" @default.
• W1978013225 hasPublicationYear "2010" @default.
• W1978013225 type Work @default.
• W1978013225 sameAs 1978013225 @default.
• W1978013225 citedByCount "10" @default.
• W1978013225 countsByYear W19780132252012 @default.
• W1978013225 countsByYear W19780132252014 @default.
• W1978013225 countsByYear W19780132252017 @default.
• W1978013225 countsByYear W19780132252018 @default.
• W1978013225 countsByYear W19780132252019 @default.
• W1978013225 countsByYear W19780132252021 @default.
• W1978013225 crossrefType "journal-article" @default.
• W1978013225 hasAuthorship W1978013225A5039596150 @default.
• W1978013225 hasAuthorship W1978013225A5070245671 @default.
• W1978013225 hasAuthorship W1978013225A5070654670 @default.
• W1978013225 hasBestOaLocation W19780132251 @default.
• W1978013225 hasConcept C121332964 @default.
• W1978013225 hasConcept C12554922 @default.
• W1978013225 hasConcept C13965031 @default.
• W1978013225 hasConcept C150903083 @default.
• W1978013225 hasConcept C150936888 @default.
• W1978013225 hasConcept C159985019 @default.
• W1978013225 hasConcept C185592680 @default.
• W1978013225 hasConcept C188027245 @default.
• W1978013225 hasConcept C192562407 @default.
• W1978013225 hasConcept C207001950 @default.
• W1978013225 hasConcept C2775997276 @default.
• W1978013225 hasConcept C2777529624 @default.
• W1978013225 hasConcept C2779732960 @default.
• W1978013225 hasConcept C2781438746 @default.
• W1978013225 hasConcept C39519442 @default.
• W1978013225 hasConcept C43617362 @default.
• W1978013225 hasConcept C55493867 @default.
• W1978013225 hasConcept C86803240 @default.
• W1978013225 hasConcept C97355855 @default.
• W1978013225 hasConceptScore W1978013225C121332964 @default.
• W1978013225 hasConceptScore W1978013225C12554922 @default.
• W1978013225 hasConceptScore W1978013225C13965031 @default.
• W1978013225 hasConceptScore W1978013225C150903083 @default.
• W1978013225 hasConceptScore W1978013225C150936888 @default.
• W1978013225 hasConceptScore W1978013225C159985019 @default.
• W1978013225 hasConceptScore W1978013225C185592680 @default.
• W1978013225 hasConceptScore W1978013225C188027245 @default.
• W1978013225 hasConceptScore W1978013225C192562407 @default.
• W1978013225 hasConceptScore W1978013225C207001950 @default.
• W1978013225 hasConceptScore W1978013225C2775997276 @default.
• W1978013225 hasConceptScore W1978013225C2777529624 @default.
• W1978013225 hasConceptScore W1978013225C2779732960 @default.
• W1978013225 hasConceptScore W1978013225C2781438746 @default.
• W1978013225 hasConceptScore W1978013225C39519442 @default.
• W1978013225 hasConceptScore W1978013225C43617362 @default.
• W1978013225 hasConceptScore W1978013225C55493867 @default.
• W1978013225 hasConceptScore W1978013225C86803240 @default.
• W1978013225 hasConceptScore W1978013225C97355855 @default.
• W1978013225 hasIssue "1" @default.
• W1978013225 hasLocation W19780132251 @default.
• W1978013225 hasLocation W19780132252 @default.
• W1978013225 hasLocation W19780132253 @default.
• W1978013225 hasLocation W19780132254 @default.
• W1978013225 hasOpenAccess W1978013225 @default.

• next