FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978016073> ?p ?o ?g. }

• W1978016073 endingPage "308" @default.
• W1978016073 startingPage "303" @default.
• W1978016073 abstract "Albendazole resistance was induced in three different Giardia cultures following growth in successively increasing amounts of drug. One of the lines was previously resistant to high levels of metronidazole and was able to grow in 2 μM albendazole. The other two survived exposure to 0.8 μM, while normally lethal levels of albendazole against Giardia in vitro were around 0.1–0.2 μM. Albendazole-resistant Giardia were cross-resistant to parbendazole. Major chromosome rearrangements were evident in the line resistant to 2 μM albendazole and IFA with antitubulin antibody indicated differences in the cytoskeleton, particularly the median body, between sensitive and resistant lines. This implicates the cytoskeleton in the mechanism of resistance. Substitution of Tyr for Phe is a consistent β-tubulin amino acid change in the benzimidazole-resistant helminths and fungi so far analyzed. PCR primers were designed from the published Giardia β-tubulin gene sequence and spanned the region encoding Phe at position 200. Sequence data from albendazole-resistant Giardia demonstrated that the β-tubulin gene did not carry a mutation in the codon for amino acid 200. These data suggest that Phe at position 200 in β-tubulin is not necessary for benzimidazole resistance." @default.
• W1978016073 created "2016-06-24" @default.
• W1978016073 creator A5001742842 @default.
• W1978016073 creator A5010952641 @default.
• W1978016073 creator A5089080093 @default.
• W1978016073 creator A5091061622 @default.
• W1978016073 date "1996-01-01" @default.
• W1978016073 modified "2023-09-23" @default.
• W1978016073 title "Albendazole Resistance in<i>Giardia</i>Is Correlated with Cytoskeletal Changes but Not with a Mutation at Amino Acid 200 in β-Tubulin" @default.
• W1978016073 cites W1546760766 @default.
• W1978016073 cites W1967266153 @default.
• W1978016073 cites W1978787129 @default.
• W1978016073 cites W1982631354 @default.
• W1978016073 cites W1982671967 @default.
• W1978016073 cites W1986866710 @default.
• W1978016073 cites W1987475267 @default.
• W1978016073 cites W1989901427 @default.
• W1978016073 cites W1995963318 @default.
• W1978016073 cites W1999073064 @default.
• W1978016073 cites W2009310436 @default.
• W1978016073 cites W2010010526 @default.
• W1978016073 cites W2011382445 @default.
• W1978016073 cites W2012539735 @default.
• W1978016073 cites W2026549605 @default.
• W1978016073 cites W2028383567 @default.
• W1978016073 cites W2029195137 @default.
• W1978016073 cites W2031302498 @default.
• W1978016073 cites W2032306168 @default.
• W1978016073 cites W2041912294 @default.
• W1978016073 cites W2043017781 @default.
• W1978016073 cites W2046832486 @default.
• W1978016073 cites W2047351812 @default.
• W1978016073 cites W2049602674 @default.
• W1978016073 cites W2054698853 @default.
• W1978016073 cites W2057164786 @default.
• W1978016073 cites W2063226427 @default.
• W1978016073 cites W2063450941 @default.
• W1978016073 cites W2070516735 @default.
• W1978016073 cites W2079328808 @default.
• W1978016073 cites W2082500382 @default.
• W1978016073 cites W2086232020 @default.
• W1978016073 cites W2086430542 @default.
• W1978016073 cites W2088375130 @default.
• W1978016073 cites W2093462329 @default.
• W1978016073 cites W2137383619 @default.
• W1978016073 cites W2180155270 @default.
• W1978016073 cites W2312843322 @default.
• W1978016073 cites W2324065479 @default.
• W1978016073 cites W959686156 @default.
• W1978016073 doi "https://doi.org/10.1089/mdr.1996.2.303" @default.
• W1978016073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9158790" @default.
• W1978016073 hasPublicationYear "1996" @default.
• W1978016073 type Work @default.
• W1978016073 sameAs 1978016073 @default.
• W1978016073 citedByCount "66" @default.
• W1978016073 countsByYear W19780160732013 @default.
• W1978016073 countsByYear W19780160732014 @default.
• W1978016073 countsByYear W19780160732015 @default.
• W1978016073 countsByYear W19780160732016 @default.
• W1978016073 countsByYear W19780160732017 @default.
• W1978016073 countsByYear W19780160732018 @default.
• W1978016073 countsByYear W19780160732019 @default.
• W1978016073 countsByYear W19780160732020 @default.
• W1978016073 countsByYear W19780160732021 @default.
• W1978016073 countsByYear W19780160732022 @default.
• W1978016073 countsByYear W19780160732023 @default.
• W1978016073 crossrefType "journal-article" @default.
• W1978016073 hasAuthorship W1978016073A5001742842 @default.
• W1978016073 hasAuthorship W1978016073A5010952641 @default.
• W1978016073 hasAuthorship W1978016073A5089080093 @default.
• W1978016073 hasAuthorship W1978016073A5091061622 @default.
• W1978016073 hasConcept C104317684 @default.
• W1978016073 hasConcept C114851261 @default.
• W1978016073 hasConcept C153911025 @default.
• W1978016073 hasConcept C18903297 @default.
• W1978016073 hasConcept C20418707 @default.
• W1978016073 hasConcept C2777065887 @default.
• W1978016073 hasConcept C2777271458 @default.
• W1978016073 hasConcept C501734568 @default.
• W1978016073 hasConcept C54355233 @default.
• W1978016073 hasConcept C84425145 @default.
• W1978016073 hasConcept C86803240 @default.
• W1978016073 hasConcept C89423630 @default.
• W1978016073 hasConceptScore W1978016073C104317684 @default.
• W1978016073 hasConceptScore W1978016073C114851261 @default.
• W1978016073 hasConceptScore W1978016073C153911025 @default.
• W1978016073 hasConceptScore W1978016073C18903297 @default.
• W1978016073 hasConceptScore W1978016073C20418707 @default.
• W1978016073 hasConceptScore W1978016073C2777065887 @default.
• W1978016073 hasConceptScore W1978016073C2777271458 @default.
• W1978016073 hasConceptScore W1978016073C501734568 @default.
• W1978016073 hasConceptScore W1978016073C54355233 @default.
• W1978016073 hasConceptScore W1978016073C84425145 @default.
• W1978016073 hasConceptScore W1978016073C86803240 @default.
• W1978016073 hasConceptScore W1978016073C89423630 @default.
• W1978016073 hasIssue "3" @default.
• W1978016073 hasLocation W19780160731 @default.
• W1978016073 hasLocation W19780160732 @default.

• next