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- W1978019610 abstract "A general stereo-directed synthesis of “ketomethylene” and “hydroxyethylene” dipeptide isosteres is reported. Peptides containing the amino acids, (2R, 5S)-5-amino-4-oxo-2,8-dimethyloctanoic acid (the “ketomethylene” analog of L-Leu-L-Ala), and (2R, 5S-5-amino-4-hydroxy-2,8-dimethyloctanoic acid (the “hydroxyethylene” analog of L-Leu-L-Ala) were synthesized as analogs of pepstatin with statine replaced by the Leu-Ala isosteres." @default.
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- W1978019610 date "1983-01-01" @default.
- W1978019610 modified "2023-10-14" @default.
- W1978019610 title "Synthesis of hydroxyethylene and ketomethylene dipeptide isosteres" @default.
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- W1978019610 doi "https://doi.org/10.1016/s0040-4039(00)85908-0" @default.
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