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• W1978027315 endingPage "2308" @default.
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• W1978027315 abstract "Objective: Despite effective treatment of HIV infection, some patients still develop non-Hodgkin lymphoma (NHL). We analysed patients with HIV-associated NHL and undetectable plasma HIV-RNA, according to the duration of HIV suppression. Methods: Out of 388 patients included in a prospective cohort of HIV-associated NHL from 1996 to 2008, 128 (33%) had a plasma HIV-RNA below 500 copies/ml and were included in the study. Patients with long-term HIV suppression (>18 months) were compared with patients with recent HIV suppression (≤18 months). Results: All patients but three were treated with combination antiretroviral therapy, with a median duration of 2.2 years. The median duration of HIV suppression was 10.1 months. Most cases (65%) occurred within 18 months following HIV suppression. In the more than 18 months group, patients developed NHL at a higher CD4 cell count than patients with 18 months or less of HIV suppression (359 versus 270 cells/μl, P = 0.02). None of the NHL characteristics were different between the two groups. Outcome was similar in the two groups (complete remission, 64 versus 72.5%; P = 0.35 and 3-year survival, 46 versus 56%; P = 0.08). In addition, 52% of the tumours were Epstein–Barr virus or human herpesvirus 8 associated, without any difference in the proportion of virus-associated tumours according to the duration of HIV suppression. Conclusion: In patients with undetectable HIV-RNA, NHL occurred mainly within the first 18 months following HIV suppression. In patients developing NHL after long-term HIV suppression, the level of CD4 cell count was higher, but the association with Epstein–Barr virus or human herpesvirus 8 and the prognosis were similar to that observed in patients with recent HIV suppression." @default.
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• W1978027315 date "2009-11-13" @default.
• W1978027315 modified "2023-09-29" @default.
• W1978027315 title "Characteristics of non-Hodgkin lymphoma arising in HIV-infected patients with suppressed HIV replication" @default.
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• W1978027315 doi "https://doi.org/10.1097/qad.0b013e328330f62d" @default.
• W1978027315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19752717" @default.
• W1978027315 hasPublicationYear "2009" @default.
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