FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978029417> ?p ?o ?g. }

• W1978029417 endingPage "75" @default.
• W1978029417 startingPage "69" @default.
• W1978029417 abstract "We investigated the contribution of eicosanoids, platelet-activating factor, tumor necrosis factor and nitric oxide to the neutrophil influx and development of pulmonary haemorrhagic lesions following immune-complex-induced pneumonitis in rats and possible interactions between these mediators. Increased levels of leukotriene B4 and tumor necrosis factor, measured by enzyme immunoassay and L-929 cytotoxicity assay, were found in the bronchoalveolar lavage 1 and 4 h after induction of the reaction, respectively, and their release was dependent on the previous generation of platelet activating factor. Antagonism of leukotriene B4 receptors by RO-0254094 (2-[(5-carboxypentyl])oxy]-6-[6-[3,4-dihydro-4-oxo-8-propyl-2H-1-benzopyran-7-yl)oxy]hexyl] benzenepropanoic acid), inhibition of nitric oxide synthesis by l-NAME (NW-nitro-l-arginine methyl ester) and antagonism of PAF-receptors by WEB-2170 (5-(2-chlorphenyl)-3-4-dihydro-10-methyl-3-((4-morpholinyl)carbonyl)-2H,7H-cyclopenta (4,5)thieno(3,2-f)(1,2,4)-triazolo-4,3,a)91,4)diazepine), significantly inhibited the intensity of haemorrhage, evaluated by the increased levels of extravascular hemoglobin in homogenates of lung tissues. Little evidence support the role of tumor necrosis factor in these lesions. The infiltration of neutrophils, evaluated by measuring myeloperoxidase in homogenates of lungs, was reduced by compounds L-663,536 (3-[1-(4 chlorobenzyl)-3-t-butyl thio-5-isopropylindol-2-yl]-2-2-dimethylpropanoic acid), WEB-2170 and l-NAME. These results indicate that neutrophil infiltration and haemorrhagic lesions in immune-complex-induced lung inflammation are mediated by platelet activating factor, leukotriene B4 and nitric oxide and point out to interesting interactions between these mediators." @default.
• W1978029417 created "2016-06-24" @default.
• W1978029417 creator A5000820500 @default.
• W1978029417 creator A5017448236 @default.
• W1978029417 creator A5031190488 @default.
• W1978029417 creator A5056072064 @default.
• W1978029417 creator A5069760725 @default.
• W1978029417 creator A5083549173 @default.
• W1978029417 date "1998-09-01" @default.
• W1978029417 modified "2023-10-18" @default.
• W1978029417 title "Lipid mediators, tumor necrosis factor and nitric oxide and their interactions in immune-complex-induced lung injury" @default.
• W1978029417 cites W135859294 @default.
• W1978029417 cites W1508678419 @default.
• W1978029417 cites W1533333239 @default.
• W1978029417 cites W1968988918 @default.
• W1978029417 cites W1976934709 @default.
• W1978029417 cites W1982740058 @default.
• W1978029417 cites W1991780446 @default.
• W1978029417 cites W1992071813 @default.
• W1978029417 cites W2011508883 @default.
• W1978029417 cites W2012757704 @default.
• W1978029417 cites W2013911376 @default.
• W1978029417 cites W2049516670 @default.
• W1978029417 cites W2056715088 @default.
• W1978029417 cites W2058137293 @default.
• W1978029417 cites W2072196714 @default.
• W1978029417 cites W2131395402 @default.
• W1978029417 cites W2138975461 @default.
• W1978029417 cites W2148000616 @default.
• W1978029417 cites W2411448402 @default.
• W1978029417 cites W4249736906 @default.
• W1978029417 cites W4313310702 @default.
• W1978029417 cites W2041022135 @default.
• W1978029417 doi "https://doi.org/10.1016/s0014-2999(98)00594-9" @default.
• W1978029417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9809871" @default.
• W1978029417 hasPublicationYear "1998" @default.
• W1978029417 type Work @default.
• W1978029417 sameAs 1978029417 @default.
• W1978029417 citedByCount "27" @default.
• W1978029417 countsByYear W19780294172013 @default.
• W1978029417 countsByYear W19780294172015 @default.
• W1978029417 crossrefType "journal-article" @default.
• W1978029417 hasAuthorship W1978029417A5000820500 @default.
• W1978029417 hasAuthorship W1978029417A5017448236 @default.
• W1978029417 hasAuthorship W1978029417A5031190488 @default.
• W1978029417 hasAuthorship W1978029417A5056072064 @default.
• W1978029417 hasAuthorship W1978029417A5069760725 @default.
• W1978029417 hasAuthorship W1978029417A5083549173 @default.
• W1978029417 hasConcept C126322002 @default.
• W1978029417 hasConcept C170493617 @default.
• W1978029417 hasConcept C178790620 @default.
• W1978029417 hasConcept C17991360 @default.
• W1978029417 hasConcept C185592680 @default.
• W1978029417 hasConcept C203014093 @default.
• W1978029417 hasConcept C203565725 @default.
• W1978029417 hasConcept C2776042228 @default.
• W1978029417 hasConcept C2776452501 @default.
• W1978029417 hasConcept C2776685179 @default.
• W1978029417 hasConcept C2776885963 @default.
• W1978029417 hasConcept C2776914184 @default.
• W1978029417 hasConcept C2777714996 @default.
• W1978029417 hasConcept C2777961210 @default.
• W1978029417 hasConcept C2779020240 @default.
• W1978029417 hasConcept C2780955469 @default.
• W1978029417 hasConcept C519581460 @default.
• W1978029417 hasConcept C55493867 @default.
• W1978029417 hasConcept C71924100 @default.
• W1978029417 hasConcept C8891405 @default.
• W1978029417 hasConcept C98274493 @default.
• W1978029417 hasConceptScore W1978029417C126322002 @default.
• W1978029417 hasConceptScore W1978029417C170493617 @default.
• W1978029417 hasConceptScore W1978029417C178790620 @default.
• W1978029417 hasConceptScore W1978029417C17991360 @default.
• W1978029417 hasConceptScore W1978029417C185592680 @default.
• W1978029417 hasConceptScore W1978029417C203014093 @default.
• W1978029417 hasConceptScore W1978029417C203565725 @default.
• W1978029417 hasConceptScore W1978029417C2776042228 @default.
• W1978029417 hasConceptScore W1978029417C2776452501 @default.
• W1978029417 hasConceptScore W1978029417C2776685179 @default.
• W1978029417 hasConceptScore W1978029417C2776885963 @default.
• W1978029417 hasConceptScore W1978029417C2776914184 @default.
• W1978029417 hasConceptScore W1978029417C2777714996 @default.
• W1978029417 hasConceptScore W1978029417C2777961210 @default.
• W1978029417 hasConceptScore W1978029417C2779020240 @default.
• W1978029417 hasConceptScore W1978029417C2780955469 @default.
• W1978029417 hasConceptScore W1978029417C519581460 @default.
• W1978029417 hasConceptScore W1978029417C55493867 @default.
• W1978029417 hasConceptScore W1978029417C71924100 @default.
• W1978029417 hasConceptScore W1978029417C8891405 @default.
• W1978029417 hasConceptScore W1978029417C98274493 @default.
• W1978029417 hasIssue "1" @default.
• W1978029417 hasLocation W19780294171 @default.
• W1978029417 hasLocation W19780294172 @default.
• W1978029417 hasOpenAccess W1978029417 @default.
• W1978029417 hasPrimaryLocation W19780294171 @default.
• W1978029417 hasRelatedWork W1896538588 @default.
• W1978029417 hasRelatedWork W1965950297 @default.
• W1978029417 hasRelatedWork W2025571159 @default.

• next