FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978029648> ?p ?o ?g. }

• W1978029648 endingPage "630" @default.
• W1978029648 startingPage "625" @default.
• W1978029648 abstract "Background: There is growing evidence that TLR2 plays a role in the pathogenesis of atherosclerosis. It is highly expressed in endothelial cells in areas of disturbed blood flow, like plaques or vessel bifurcations, but laminar blood flow suppresses endothelial TLR2 expression and is therefore thought to be atheroprotective. We sought for means to also protect lesion prone sites from TLR2 over-expression and subsequent endothelial activation. Methods: Human coronary artery endothelial cells (HCAEC) were treated with atorvastatin (ATV) and TLR2 surface expression was determined by FACS analyses. Western blot analyses were used to explore the phosphorylation status of SP1. Results: ATV profoundly inhibited basal and stimulated endothelial TLR2 expression in a time- and dose-dependent manner. It also inhibited HCAEC activation by MALP-2. TLR2 surface expression was inversely correlated to SP1 serine phosphorylation and was casein kinase 2 dependent. Conclusion: We demonstrate that ATV can control over-expression of proinflammatory endothelial TLR2 protein and TLR2-mediated endothelial activation. The mechanism involves casein kinase 2 and SP1 phosphorylation. ATV effects on endothelial cell TLR2 are comparable to those of laminar blood flow and might therefore also be atheroprotective." @default.
• W1978029648 created "2016-06-24" @default.
• W1978029648 creator A5028816041 @default.
• W1978029648 creator A5039584453 @default.
• W1978029648 creator A5057599018 @default.
• W1978029648 creator A5070249577 @default.
• W1978029648 creator A5083589962 @default.
• W1978029648 creator A5091115245 @default.
• W1978029648 date "2011-01-01" @default.
• W1978029648 modified "2023-10-03" @default.
• W1978029648 title "Atorvastatin Inhibits Functional Expression of Proatherogenic TLR2 in Arterial Endothelial Cells" @default.
• W1978029648 cites W1595790490 @default.
• W1978029648 cites W1978369960 @default.
• W1978029648 cites W1978877435 @default.
• W1978029648 cites W2004773897 @default.
• W1978029648 cites W2018788678 @default.
• W1978029648 cites W2024815256 @default.
• W1978029648 cites W2029551349 @default.
• W1978029648 cites W2030237203 @default.
• W1978029648 cites W2065123578 @default.
• W1978029648 cites W2066963386 @default.
• W1978029648 cites W2083709056 @default.
• W1978029648 cites W2088469326 @default.
• W1978029648 cites W2097863443 @default.
• W1978029648 cites W2098522155 @default.
• W1978029648 cites W2109148136 @default.
• W1978029648 cites W2114918609 @default.
• W1978029648 cites W2120272302 @default.
• W1978029648 cites W2120463547 @default.
• W1978029648 cites W2137173039 @default.
• W1978029648 cites W2143835519 @default.
• W1978029648 cites W2150576278 @default.
• W1978029648 cites W2152415811 @default.
• W1978029648 cites W2157752762 @default.
• W1978029648 cites W2158754447 @default.
• W1978029648 cites W4296981756 @default.
• W1978029648 doi "https://doi.org/10.1159/000335758" @default.
• W1978029648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22178874" @default.
• W1978029648 hasPublicationYear "2011" @default.
• W1978029648 type Work @default.
• W1978029648 sameAs 1978029648 @default.
• W1978029648 citedByCount "11" @default.
• W1978029648 countsByYear W19780296482012 @default.
• W1978029648 countsByYear W19780296482013 @default.
• W1978029648 countsByYear W19780296482014 @default.
• W1978029648 countsByYear W19780296482016 @default.
• W1978029648 countsByYear W19780296482018 @default.
• W1978029648 countsByYear W19780296482019 @default.
• W1978029648 countsByYear W19780296482020 @default.
• W1978029648 countsByYear W19780296482021 @default.
• W1978029648 crossrefType "journal-article" @default.
• W1978029648 hasAuthorship W1978029648A5028816041 @default.
• W1978029648 hasAuthorship W1978029648A5039584453 @default.
• W1978029648 hasAuthorship W1978029648A5057599018 @default.
• W1978029648 hasAuthorship W1978029648A5070249577 @default.
• W1978029648 hasAuthorship W1978029648A5083589962 @default.
• W1978029648 hasAuthorship W1978029648A5091115245 @default.
• W1978029648 hasBestOaLocation W19780296481 @default.
• W1978029648 hasConcept C104317684 @default.
• W1978029648 hasConcept C11960822 @default.
• W1978029648 hasConcept C123012128 @default.
• W1978029648 hasConcept C126322002 @default.
• W1978029648 hasConcept C134018914 @default.
• W1978029648 hasConcept C164027704 @default.
• W1978029648 hasConcept C185592680 @default.
• W1978029648 hasConcept C202751555 @default.
• W1978029648 hasConcept C203014093 @default.
• W1978029648 hasConcept C2776070231 @default.
• W1978029648 hasConcept C2776415932 @default.
• W1978029648 hasConcept C2776914184 @default.
• W1978029648 hasConcept C2777482532 @default.
• W1978029648 hasConcept C2780972559 @default.
• W1978029648 hasConcept C2781236682 @default.
• W1978029648 hasConcept C553184892 @default.
• W1978029648 hasConcept C55493867 @default.
• W1978029648 hasConcept C62478195 @default.
• W1978029648 hasConcept C71924100 @default.
• W1978029648 hasConcept C86803240 @default.
• W1978029648 hasConcept C95444343 @default.
• W1978029648 hasConceptScore W1978029648C104317684 @default.
• W1978029648 hasConceptScore W1978029648C11960822 @default.
• W1978029648 hasConceptScore W1978029648C123012128 @default.
• W1978029648 hasConceptScore W1978029648C126322002 @default.
• W1978029648 hasConceptScore W1978029648C134018914 @default.
• W1978029648 hasConceptScore W1978029648C164027704 @default.
• W1978029648 hasConceptScore W1978029648C185592680 @default.
• W1978029648 hasConceptScore W1978029648C202751555 @default.
• W1978029648 hasConceptScore W1978029648C203014093 @default.
• W1978029648 hasConceptScore W1978029648C2776070231 @default.
• W1978029648 hasConceptScore W1978029648C2776415932 @default.
• W1978029648 hasConceptScore W1978029648C2776914184 @default.
• W1978029648 hasConceptScore W1978029648C2777482532 @default.
• W1978029648 hasConceptScore W1978029648C2780972559 @default.
• W1978029648 hasConceptScore W1978029648C2781236682 @default.
• W1978029648 hasConceptScore W1978029648C553184892 @default.
• W1978029648 hasConceptScore W1978029648C55493867 @default.
• W1978029648 hasConceptScore W1978029648C62478195 @default.
• W1978029648 hasConceptScore W1978029648C71924100 @default.

• next