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• W1978039145 abstract "Fluorescent dansylated derivatives of enkephalins were prepared, with the dansyl group either at the N- or C-terminal part of methionine-enkephalin (Met-E) or its peptidase-resistant analogue D-Ala2-Met-E. An energy transfer, from the Tyr to the dansyl group, was found for all compounds and spectral properties were dependent upon the environment polarity. Met-E-(CH2)2 dansyl II and D-Ala2-Met-E-(CH2)2 dansyl III exhibit biological activities on guinea-pig ileum and binding affinities on striatal membranes, similar to Met-E. III exhibits significant analgesic activity in mice after i.v. administration (about 35 % that of morphine). Fluorescent enkephalins potentially represent useful probes for the exploration of opiate receptors, studies of ligand-receptor interactions and evaluation of enkephalins cleaving peptidases in various tissues." @default.
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• W1978039145 date "1978-07-01" @default.
• W1978039145 modified "2023-10-01" @default.
• W1978039145 title "Fluorescent enkephalin derivatives with biological activity" @default.
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• W1978039145 doi "https://doi.org/10.1016/0006-291x(78)90431-x" @default.
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