Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978045299> ?p ?o ?g. }
- W1978045299 endingPage "28" @default.
- W1978045299 startingPage "1" @default.
- W1978045299 abstract "Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin resistance and lipid accretion in liver (i.e. hepatic steatosis), which can lead to steatohepatitis. Steatosis and nonalcoholic steatohepatitis (NASH) can also be induced by drugs such as amiodarone, tamoxifen and some antiretroviral drugs, including stavudine and zidovudine. There is accumulating evidence that mitochondrial dysfunction (more particularly respiratory chain deficiency) plays a key role in the physiopathology of NASH whatever its initial cause. In contrast, the mitochondrial beta-oxidation of fatty acids can be either increased (as in insulin resistance-associated NASH) or decreased (as in drug-induced NASH). However, in both circumstances, generation of reactive oxygen species (ROS) by the damaged respiratory chain can be augmented. ROS generation in an environment enriched in lipids in turn induces lipid peroxidation which releases highly reactive aldehydic derivatives (e.g. malondialdehyde) that have diverse detrimental effects on hepatocytes and other hepatic cells. In hepatocytes, ROS, reactive nitrogen species and lipid peroxidation products further impair the respiratory chain, either directly or indirectly through oxidative damage to the mitochondrial genome. This consequently leads to the generation of more ROS and a vicious cycle occurs. Mitochondrial dysfunction can also lead to apoptosis or necrosis depending on the energy status of the cell. ROS and lipid peroxidation products also increase the generation of several cytokines (TNF-alpha, TGF-beta, Fas ligand) playing a key role in cell death, inflammation and fibrosis. Recent investigations have shown that some genetic polymorphisms can significantly increase the risk of steatohepatitis and that several drugs can prevent or even reverse NASH. Interestingly, most of these drugs could exert their beneficial effects by improving directly or indirectly mitochondrial function in liver. Finding a drug, which could fully prevent oxidative stress and mitochondrial dysfunction in NASH is a major challenge for the next decade." @default.
- W1978045299 created "2016-06-24" @default.
- W1978045299 creator A5014451095 @default.
- W1978045299 creator A5021292416 @default.
- W1978045299 creator A5021514439 @default.
- W1978045299 creator A5035818196 @default.
- W1978045299 date "2006-02-01" @default.
- W1978045299 modified "2023-10-18" @default.
- W1978045299 title "Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it" @default.
- W1978045299 cites W1507432389 @default.
- W1978045299 cites W1518557248 @default.
- W1978045299 cites W1527986744 @default.
- W1978045299 cites W1530129189 @default.
- W1978045299 cites W1533795485 @default.
- W1978045299 cites W1536698969 @default.
- W1978045299 cites W1551770211 @default.
- W1978045299 cites W1573329752 @default.
- W1978045299 cites W1598875012 @default.
- W1978045299 cites W1631449371 @default.
- W1978045299 cites W1657305554 @default.
- W1978045299 cites W1748636648 @default.
- W1978045299 cites W1760567925 @default.
- W1978045299 cites W1764140709 @default.
- W1978045299 cites W1784102749 @default.
- W1978045299 cites W1792349674 @default.
- W1978045299 cites W1818080689 @default.
- W1978045299 cites W1825742435 @default.
- W1978045299 cites W1828550268 @default.
- W1978045299 cites W1927710737 @default.
- W1978045299 cites W1949014864 @default.
- W1978045299 cites W1963533730 @default.
- W1978045299 cites W1963594193 @default.
- W1978045299 cites W1964624702 @default.
- W1978045299 cites W1966607943 @default.
- W1978045299 cites W1967195358 @default.
- W1978045299 cites W1967251260 @default.
- W1978045299 cites W1967993903 @default.
- W1978045299 cites W1968396962 @default.
- W1978045299 cites W1969856624 @default.
- W1978045299 cites W1970781279 @default.
- W1978045299 cites W1972744939 @default.
- W1978045299 cites W1973573989 @default.
- W1978045299 cites W1973749169 @default.
- W1978045299 cites W1974302922 @default.
- W1978045299 cites W1974436444 @default.
- W1978045299 cites W1974750930 @default.
- W1978045299 cites W1975015881 @default.
- W1978045299 cites W1977190397 @default.
- W1978045299 cites W1978679812 @default.
- W1978045299 cites W1978684392 @default.
- W1978045299 cites W1979323366 @default.
- W1978045299 cites W1979590516 @default.
- W1978045299 cites W1979634154 @default.
- W1978045299 cites W1979731389 @default.
- W1978045299 cites W1979867739 @default.
- W1978045299 cites W1981018347 @default.
- W1978045299 cites W1981745412 @default.
- W1978045299 cites W1982578021 @default.
- W1978045299 cites W1982584622 @default.
- W1978045299 cites W1982840282 @default.
- W1978045299 cites W1983336199 @default.
- W1978045299 cites W1984191109 @default.
- W1978045299 cites W1984937308 @default.
- W1978045299 cites W1986776189 @default.
- W1978045299 cites W1988065964 @default.
- W1978045299 cites W1988269137 @default.
- W1978045299 cites W1988445776 @default.
- W1978045299 cites W1988981256 @default.
- W1978045299 cites W1990319295 @default.
- W1978045299 cites W1991906287 @default.
- W1978045299 cites W1993742623 @default.
- W1978045299 cites W1995011390 @default.
- W1978045299 cites W1995069275 @default.
- W1978045299 cites W1995261559 @default.
- W1978045299 cites W1996536878 @default.
- W1978045299 cites W1996641308 @default.
- W1978045299 cites W1996905851 @default.
- W1978045299 cites W1997726248 @default.
- W1978045299 cites W1997757821 @default.
- W1978045299 cites W1999975112 @default.
- W1978045299 cites W2001349068 @default.
- W1978045299 cites W2002008036 @default.
- W1978045299 cites W2002644253 @default.
- W1978045299 cites W2002921346 @default.
- W1978045299 cites W2003322777 @default.
- W1978045299 cites W2003403665 @default.
- W1978045299 cites W2006088607 @default.
- W1978045299 cites W2007078899 @default.
- W1978045299 cites W2007359989 @default.
- W1978045299 cites W2010199010 @default.
- W1978045299 cites W2010520981 @default.
- W1978045299 cites W2010746044 @default.
- W1978045299 cites W2011246715 @default.
- W1978045299 cites W2011442156 @default.
- W1978045299 cites W2011839999 @default.
- W1978045299 cites W2012295774 @default.
- W1978045299 cites W2013127483 @default.
- W1978045299 cites W2015479739 @default.