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- W1978049471 abstract "Regulation of phosphate transport by insulin was investigated in brush border membranes from human placenta at term. At 22°C, a 45 min incubation of the total tissue with 10−6 M insulin significantly decreased both the initial rate and the peak of sodium-dependent phosphate uptake by the corresponding brush border membranes. In contrast, Na+ transport was not influenced by the hormone. Increasing the insulin concentration from 0 to 10−5 M resulted in a dose-dependent inhibition of phosphate uptake with half-maximal effect at 1.1 × 10−9 M. The hormone decreased PO4 transport by decreasing the affinity of the carrier for the substrate (Km = 0.180 ± 0.010 mM and 0.215 ± 0.015 mM in absence and presence of 10 −6 M insulin respectively, P < 0.05). The inhibitory effect of insulin required the presence of Mn2+ whereas neither Mn2+ nor insulin alone had any influence on PO4 uptake. It is therefore assumed that receptor phosphorylation, which needs the presence of Mn2+, is an intermediate step of insulin action on PO4 uptake by the subsequently isolated brush border membranes. In contrast, insulin had no effect on PO4 uptake when the membranes were directly incubated with the hormone prior to the transport measurement, suggesting that an intracellular messenger is needed for the inhibitory effect. This messenger is not cAMP since insulin at 10−6 M concentration has no effect on cAMP content of the total placental tissue. Since insulin binding occurs predominantly if not exclusively on the brush border membrane facing the maternal blood compartment, it is assumed that only the maternal insulin influences the phosphate transport through the placenta." @default.
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- W1978049471 date "1989-05-01" @default.
- W1978049471 modified "2023-10-17" @default.
- W1978049471 title "Influence of insulin on phosphate uptake by brush border membranes from human placenta" @default.
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- W1978049471 doi "https://doi.org/10.1016/0303-7207(89)90081-6" @default.
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